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Leukotrienes in Endotoxin Shock

  • W. Hagmann
  • C. Denzlinger
  • S. Rapp
  • D. Keppler
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 139)

Abstract

Actions of endotoxin (1ipopolysaccharide, LPS) in vivo have long been suggested to be mediated by arachidonate metabolites (1,2). The important role of arachidonate-derived metabolites including leukotrienes, prostaglandins and thromboxane in experimental LPS shock has been deduced from the LPS resistance of essential fatty acid-deficient rats (3,4), from the altered arachidonate metabolism in LPS-tolerant rats (5), as well as from pharmacological evidence (1,2,6,7). Recent studies showed that the LPS-resistant C3H/HeJ mouse strain, whose macrophages are defective in prostaglandin (8,9) and leukotriene synthesis (10), can be made highly LPS-sensitive by transfer of pure macrophages from LPS-sensitive C3H/HeN mice (11). These data stress the target cell role of macrophages in the in vivo action of LPS (8,11).

Keywords

Bile Duct Ligation Circ Shock Endotoxin Shock Pharmacological Evidence Lethal Action 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    J.R. Parratt in: Pathophysiology of endotoxin (ed.: L.B. Hinshaw). Elsevier Science Publishers (Amsterdam) p. 203 (1985).Google Scholar
  2. 2.
    J.T. Flynn in: Pathophysiology of endotoxin (ed.: L.B. Hinshaw). Elsevier Science Publishers (Amsterdam) p. 237 (1985).Google Scholar
  3. 3.
    J.A. Cook, W.C. Wise, and Callihan, C.S. Circ Shock 6: 333 (1979).PubMedGoogle Scholar
  4. 4.
    J.A. Cook, P.V. Halushka, and Wise, W.C. Circ Shock 9: 605 (1982).PubMedGoogle Scholar
  5. 5.
    W.C. Wise, J.A. Cook, and Halushka, P.V. Advances Shock Res 10: 131 (1983).Google Scholar
  6. 6.
    W. Hagmann, and Keppler, D. Naturwiss, 69: 594 (1982).CrossRefGoogle Scholar
  7. 7.
    W. Hagmann, C. Denzlinger, and Keppler, D. Circ Shock 14: 223 (1984).PubMedGoogle Scholar
  8. 8.
    L.M. Wahl, D.L. Rosenstreich, L.M. Glode, A.L. Sandberg, and Mergenhagen, S.E. Infect Immun 23: 8 (1979).PubMedGoogle Scholar
  9. 9.
    E.Th. Rietschel, U. Schade, M. Jensen, H.W. Wollenweber, O. Luderitz, and Greisman, S.G. Scand J Infect Dis Suppl, 31:8 (1982).Google Scholar
  10. 10.
    T. Luderitz, A. Roth, U. Schade, and Rietschel, E.Th. EOS-J Immunol Immunopharmacol Suppl, 6: 204 (1986).Google Scholar
  11. 11.
    M.A. Freudenberg, D. Keppler, and Galanos, C. Infect Immun 51: 891 (1986).Google Scholar
  12. 12.
    B. Samuelsson. Science 220: 568 (1983).PubMedCrossRefGoogle Scholar
  13. 13.
    G. Feuerstein. Prostaglandins 27: 781 (1984).PubMedCrossRefGoogle Scholar
  14. 14.
    A.M. Lefer. Biochem Pharmacol 35: 123 (1986).PubMedCrossRefGoogle Scholar
  15. 15.
    X.Y. Hua, S.E. Dahlen, J.M. Lundberg, S. Hammarstrom, and Hedqvist, P. Naunyn-Schmiedeberg’s Arch Pharmacol 330: 136 (1985).CrossRefGoogle Scholar
  16. 16.
    L.B. Hinshaw in: Pathophysiology of shock, anoxia, and ischemia (eds.:R.A. Cowley, B.F. Trump). Williams & Wilkins (Baltimore) p. 219 (1982).Google Scholar
  17. 17.
    C. Galaros, M.A. Freudenberg, and Reutter, W. Proc Natl Acad Sci USA 76: 5939 (1979).CrossRefGoogle Scholar
  18. 18.
    D. Keppler, J. Pausch, and Decker, K. J Biol Chem, 249: 211 (1974).Google Scholar
  19. 19.
    H.W. Seyberth, H. Schmidt-Gayk, and Hackenthal, E. Toxicon 10: 491 (1972).CrossRefGoogle Scholar
  20. 20.
    M. Di Rosa, R.J. Flower, F. Hirata, L. Parente, and Russo-Marie, F. Prostaglandins 28: 441 (1984).CrossRefGoogle Scholar
  21. 21.
    R.W. Randall, K.E. Eakins, G.A. Higgs, J.A. Salmon, and Tateson, J.E. Agent Action 10: 553 (1980).CrossRefGoogle Scholar
  22. 22.
    W.R. Mathews, and Murphy, R.C. Biochem Pharmacol, 31: 2129 (1982).PubMedCrossRefGoogle Scholar
  23. 23.
    J. Augstein, J.B. Farmer, T.B. Lee, P. Sheard, and Tattersall, M.L. Nature, New Biology 245: 215 (1973).CrossRefGoogle Scholar
  24. 24.
    J.H. Fleisch, L.E. Rinkema, K.D. Haisch, D. Swanson-Bean, T. Goodson, P.P.K. Ho, and Marshall, W.S. J Pharmacol Exp Therapeut 233: 148 (1985).Google Scholar
  25. 25.
    R. Ceserani, M. Colombo, and Mandelli, V. Prostaglandins Med 2: 337 (1979).CrossRefGoogle Scholar
  26. 26.
    M.K. Bach in: The Leukotrienes, Chemistry and Biology (eds.: L.W. Chakrin, D.M. Bailey). Academic Press (Orlando) p. 163 (1984).Google Scholar
  27. 27.
    C. Oenzlinger, S. Rapp, W. Hagmann, and Keppler, D. Science 230: 330 (1985).Google Scholar
  28. 28.
    D. Keppler, W. Hagmann, S. Rapp, C. Denzlinger, and Koch, H.K. Hepatology 5: 883 (1985). PubMedCrossRefGoogle Scholar
  29. 29.
    W. Hagmann, C. Denzlinger, and Keppler, D. FEBS Lett 180: 309 (1985).CrossRefGoogle Scholar
  30. 30.
    W. Hagmann, C. Denzlinger, S. Rapp, G. Weckbecker, and Keppler, D. Prostaglandins 31: 239 (1986).CrossRefGoogle Scholar
  31. 31.
    K. Tanamoto, U. Zahringer, G.R. McKenzie, C. Galanos, E.Th. Rietschel, O. Luderitz, S. Kusumoto, and Shiba, T. Infect Immun 44: 421 (1984).PubMedGoogle Scholar
  32. 32.
    D. Keppler, W. Hagmann, and Rapp, S. Rev Infect Dis (1986) in press.Google Scholar
  33. 33.
    E.N. Wardle, and Wright, N.A. Br Med J 4: 472 (1970).PubMedCrossRefGoogle Scholar
  34. 34.
    A.M. Lefer in: Handbook of Shock and Trauma, Vol 1: Basic Science (eds.: B.M. Altura, A.M. Lefer, W. Schumer). Raven Press (New York) p. 355 (1983).Google Scholar
  35. 35.
    R. Roubin, and Benveniste, J. Comp Immun Microbiol Infect Dis 8: 109 (1985).CrossRefGoogle Scholar
  36. 36.
    N.F. Voelkel, J.T. Reeves, P.M. Henson, and Murphy, R.C. Science 218: 286 (1982).PubMedCrossRefGoogle Scholar
  37. 37.
    J.M. Young, P.J. Moloney, S.N. Jubb, and Clark, J.S. Prostaglandins 30: 545 (1985). PubMedCrossRefGoogle Scholar
  38. 38.
    B. Beutler, I.W. Milsark, and Cerami, A.C. Science 229: 869 (1985).PubMedCrossRefGoogle Scholar
  39. 39.
    A. Koj in: Pathophysiology of Plasma Protein Metabolism (ed.: G. Mariani). McMillan (London) p. 221 (1984).Google Scholar
  40. 40.
    A. Koj in: The acute-phase response to injury and infection. The roles of interleukin-1 and other mediators (eds.: A.H. Gordon, A. Koj). Elsevier Science Publishers (Amsterdam) p. 173 (1985)Google Scholar
  41. 41.
    B. Beutler, N. Krochin, I.W. Milsark, C. Luedke, and Cerami, A. Science 232: 977 (1986).Google Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • W. Hagmann
    • 1
  • C. Denzlinger
    • 1
  • S. Rapp
    • 1
  • D. Keppler
    • 1
  1. 1.Biochemisches InstitutUniversity of FreiburgFreiburgWest Germany

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