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Mass Spectrometry of Bile Acids

  • A. M. Lawson
  • K. D. R. Setchell

Abstract

The continued use over many years of mass spectrometry (MS) for bile acid analysis can be attributed to its value as a method for providing definitive qualitative and quantitative information. Its combination with gas chromatography (GC—MS) has been particularly important for investigating the stereochemical variety of the structure of bile acids in relation to their biosynthesis, transport, and metabolism.

Keywords

Bile Acid Cholic Acid Chenodeoxycholic Acid Lithocholic Acid Serum Bile Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    J. Sjövall, P. Eneroth, and R. Ryhage, in “The Bile Acids; Chemistry, Physiology and Metabolism” (P. P. Nair and D. Kritchevsky, eds.), pp. 209–248, Plenum Press, New York (1971).Google Scholar
  2. 2.
    J. G. Liehr, E. E. Kingston, and J. H. Beynon, Biomed. Mass Spectrom. 12, 95 (1985).PubMedCrossRefGoogle Scholar
  3. 3.
    J. H. Beynon, R. G. Cooks, J. W. Amy, W. E. Baitinger, and T. Ridley, Anal. Chem. 45, 1023A (1973).Google Scholar
  4. 4.
    D. F. Hunt, J. Shabanowitz, and A. B. Gyiordani, Anal. Chem. 52, 386 (1980).CrossRefGoogle Scholar
  5. 5.
    F. W. McLafferty, “Tandem Mass Spectrometry,” New York (1983).Google Scholar
  6. 6.
    J. R. Chapman, “Computers in Mass Spectrometry,” Academic Press, London-New York-San Francisco (1978).Google Scholar
  7. 7.
    R. A. Hites, and K. Biemann, Anal. Chem. 42, 855 (1970).CrossRefGoogle Scholar
  8. 8.
    C. C. Sweeley, N. D. Young, J. F. Holland, and S. C. Gates, J. Chromatogr. 99, 507 (1974).PubMedCrossRefGoogle Scholar
  9. 9.
    B. J. Kimble, R. E. Cox, R. V. McPherron, R. W. Olsen, E. Roitman, F. C. Walls, and A. L. Burlingame, J. Chromatogr. Sci. 12, 647 (1974).PubMedGoogle Scholar
  10. 10.
    J. E. Biller, and K. Biemann, Anal. Lett. 7, 515 (1974).Google Scholar
  11. 11.
    H. Nau, and K. Biemann, Anal. Chem. 46, 426 (1974).PubMedCrossRefGoogle Scholar
  12. 12.
    R. Reimendal, and J. Sjövall. Anal. Chem. 45, 1083 (1973).CrossRefGoogle Scholar
  13. 13.
    B. Aimé, A. Bremmelgaard, J. Sjövall, and P. Thomassen, J. Lipid Res. 18, 339 (1977).Google Scholar
  14. 14.
    L. Baczynskyji, D. J. Duchamp, J. F. Ziesel, and U. Axen, Anal. Chem. 45, 479 (1973).CrossRefGoogle Scholar
  15. 15.
    R. C. Murphy, S. E. Hattox, and H. R. Helbig, Biomed. Mass Spectrom. 5, 444 (1978).PubMedCrossRefGoogle Scholar
  16. 16.
    Z. R. Vlahcevic, T. Cronholm, T. Curstedt, and J. Sjövall, Biochim. Biophys. Acta 618, 369 (1980).PubMedGoogle Scholar
  17. 17.
    F. C. Falkner, B. J. Sweetman, and J. T. Watson, Appl. Spectrosc. Rev. 10, 51 (1975).CrossRefGoogle Scholar
  18. 18.
    S. C. Gates, M. J. Smisko, C. L. Ashendel, N. D. Young, J. F. Holland, and C. C. Sweeley, Anal. Chem. 50, 433 (1978).CrossRefGoogle Scholar
  19. 19.
    S. C. Gates, N. Dendramis, and C. C. Sweeley, Clin. Chem. 24, 1674 (1978).PubMedGoogle Scholar
  20. 20.
    G. M. Muschik, L. H. Wright, and J. A. Schroer, Biomed. Mass Spectrom. 6, 166 (1979).CrossRefGoogle Scholar
  21. 21.
    P. A. Szczepanik, D. L. Hachey, and P. D. Klein, J. Lipid Res. 17, 314 (1976).PubMedGoogle Scholar
  22. 22.
    K. Kuriyama, Y. Ban, T. Nakashima, and T. Murata, Steroids 34, 717 (1979).PubMedCrossRefGoogle Scholar
  23. 23.
    B. R. DeMark, and P. D. Klein, J. Lipid Res. 22, 166 (1981).PubMedGoogle Scholar
  24. 24.
    T. Murata, S. Takahashi, S. Ohnishi, K. Hosoi, T. Nakashima, Y. Ban, and K. Kuriyama, J. Chromatogr. 239, 571 (1982).CrossRefGoogle Scholar
  25. 25.
    B. L. Jelus, B. Munson, and C. Fenselau, Biomed. Mass Spectrom. 1, 96 (1974).PubMedCrossRefGoogle Scholar
  26. 26.
    B. Jelus, B. Munson, and C. Fenselau, Anal. Chem. 46, 729 (1974).PubMedCrossRefGoogle Scholar
  27. 27.
    A. K. Bose, H. Fujiwara, B. N. Pramanik, E. Lazaro, and C. R. Spillert, Anal. Biochem. 89, 284 (1978).PubMedCrossRefGoogle Scholar
  28. 28.
    A. G. Harrison, “Chemical Ionization Mass Spectrometry,” CRC Press, Boca Raton, FL (1983).Google Scholar
  29. 29.
    H. D. Beckey, “Principles of Field Ionization and Field Desorption Mass Spectrometry,” Pergamon, Oxford, England (1977).Google Scholar
  30. 30.
    D. E. Games, M. P. Games, A. H. Jackson, A. H. Olavesen, M. Rossiter, and P. J. Winterburn, Tetrahedron. Lett. 27, 2377 (1974).CrossRefGoogle Scholar
  31. 31.
    R. Shaw and W. H. Elliott, Biomed. Mass Spectrom. 5, 433 (1978).PubMedCrossRefGoogle Scholar
  32. 32.
    J. O. Whitney, S. Lewis, K. M. Straub, M. M. Thaler, and A. L. Burlingame, (Proc. Jap. Soc. Med. Mass Spectrom.) Koenshu-Iyo Masu Kenkyukai 6, 33 (1981).Google Scholar
  33. 33.
    R. J. Cotter, Anal. Chem. 53, 719 (1981).CrossRefGoogle Scholar
  34. 34.
    R. J. Day, J. Zimmerman, and D. M. Hercules, Spectroscopy Lett. 14, 773 (1981).CrossRefGoogle Scholar
  35. 35.
    A. Benninghoven, D. Jaspers, and W. K. Sichtermann, Appi. Physiol. 11, 35 (1976).CrossRefGoogle Scholar
  36. 36.
    M. Barber, R. S. Bordoli, R. D. Sedgwick, and A. N. Tyler, Nature 293, 270 (1981).CrossRefGoogle Scholar
  37. 37.
    J. O. Whitney and A. L. Burlingame, Koenshu-Iyo Masu Kenkyukai 7, 3 (1982).Google Scholar
  38. 38.
    J. O. Whitney, M. M. Thaler, and N. Blanckert, in “Bile Acids and Cholesterol in Health and Disease” (G. Paumgartner, A. Stiehl, and W. Gerok, eds.) p. 213, MTP Press Ltd., Lancaster, England (1983).Google Scholar
  39. 39.
    J. O. Whitney, S. Lewis, K. M. Straub, F. C. Walls, A. L. Burlingame, and M. M. Thaler, in“Proceedings 29th Annual Conference Mass Spectrometry,” Allied Topics, American Society for Mass Spectrometry, Minneapolis, p. 729 (1981).Google Scholar
  40. 40.
    J. O. Whitney, V. Ling, D. Grunberger, M. M. Thaler, and A. L. Burlingame, Proc. Jap. Soc. Med. Mass Spectrom. 8, 47 (1983).Google Scholar
  41. 41.
    J. O. Whitney, D. Grunberger, E. Roitman, V. Ling, Y-M. Yang, P. Rosenthal, and A. L. Burlingame, in “Proceedings 32nd Annual Conference Mass Spectrometry,” Allied Topics, American Society of Mass Spectrometry, San Antonio, p. 133 (1984).Google Scholar
  42. 42.
    J. G. Liehr, C. F. Beckner, A. M. Ballatore, and R. M. Caprioli, in “Proceedings 30th Annual Conference Mass Spectrometry,” Allied Topics, American Society of Mass Spectrometry, Honolulu, p. 234 (1982).Google Scholar
  43. 43.
    Y. Itagaki, T. Higuchi, Y. Naito, J. Goto, and T. Nambara, in “Proceedings 30th Annual Conference Mass Spectrometry,” Allied Topics, American Society of Mass Spectrometry, Honolulu, p. 236 (1982).Google Scholar
  44. 44.
    A. M. Ballatore, C. F. Beckner, R. M. Caprioli, N. E. Hoffman, and J. G. Liehr, Steroids, 41, 198 (1983).CrossRefGoogle Scholar
  45. 45.
    A. M. Lawson, C. Bayliss, and K. D. R. Setchell, “Presented at VIII International Bile Acid Meeting, Enterohepatic Circulation of Bile Acids and Sterol Metabolism,” Berne, p. 260 (Abstract) (1984).Google Scholar
  46. 46.
    A. M. Lawson, K. D. R. Setchell, and C. Bayliss, in “Proceedings British Mass Spectrometry Society,” British Mass Spectrometry Society, Edinburgh, p. 119 (1984).Google Scholar
  47. 47.
    J. Sjövall, A. M. Lawson, and K. D. R. Setchell, in “Methods in Enzymology” (J. H. Law and H. C. Rilling, eds.), Volume 111, p. 63 Academic Press, London, (1985).Google Scholar
  48. 48.
    K. B. Tomer, N. J. Jensen, and J. O. Whitney, in “Proceedings 33rd Annual Conference Mass Spectrometry,” Allied Topics, American Society of Mass Spectrometry, San Diego, p. 703 (1985);Google Scholar
  49. K. B. Tomer, N. J. Jensen, M. L. Gross, and J. Whitney, Biomed. Mass Spectrom. 12, 265 (1985).Google Scholar
  50. 49.
    P. D. G. Dean and R. T. Aplin, Steroids 8, 565 (1966).PubMedCrossRefGoogle Scholar
  51. 50.
    H. Egger, Monatsh. Chem. 99, 1163 (1968).CrossRefGoogle Scholar
  52. 51.
    M. A. Baldwin and F. W. McLafferty, Org. Mass Spectrom. 7, 1353 (1973).CrossRefGoogle Scholar
  53. 52.
    R. J. Cotter, Anal. Chem. 52, 1589A (1980).CrossRefGoogle Scholar
  54. 53.
    S. Bergström, R. Ryhage, and E. Stenhagen, Acta Chem. Scand. 12, 1349 (1958).CrossRefGoogle Scholar
  55. 54.
    R. Ryhage and E. Stenhagen, J. Lipid Res. 1, 361 (1960).PubMedGoogle Scholar
  56. 55.
    S. Bergström, R. Ryhage, and E. Stenhagen, Svensk. Kem. Tidskr. 73, 566 (1961).Google Scholar
  57. 56.
    W. H. Elliott, in “Biochemical Applications of Mass Spectrometry—Mass Spectra of Bile Acids” (G. R. Waller, ed.), Wiley Interscience, New York, London, p. 291 (1972).Google Scholar
  58. 57.
    W. H. Elliott, in“Biochemical Applications of Mass Spectrometry—Mass Spectra of Bile Acids” First Supplementary Volume (G. R. Waller and O. C. Dermer, eds.), Wiley-Inter-science, New York, London, p. 229 (1980).Google Scholar
  59. 58.
    H. Miyazaki, M. Ishibashi, and K. Yamashita, Biomed. Mass Spectrom. 5, 469 (1978).PubMedCrossRefGoogle Scholar
  60. 59.
    A. Fukunaga, Y. Hatta, M. Ishibashi, and H. Miyazaki, J. Chromatogr. 190, 339 (1980).PubMedCrossRefGoogle Scholar
  61. 60.
    S. H. G. Andersson and J. Sjövall, J. Chromatogr. 289, 195 (1984).PubMedCrossRefGoogle Scholar
  62. 61.
    C. G. Edmonds, J. A. McCloskey, and V. A. Edmonds, Biomed. Mass Spectrom. 10, 237 (1983).CrossRefGoogle Scholar
  63. 62.
    T. P. Fan, E. D. Hardin, and M. L. Vestal, Anal. Chem. 56, 1870 (1984).PubMedCrossRefGoogle Scholar
  64. 63.
    M. Dedieu, C. Juin, P. J. Arpino, J. P. Bounine, and G. Guiochon, J. Chromatogr. 251, 203 (1982).CrossRefGoogle Scholar
  65. 64.
    C. R. Blakley, J. J. Carmody, and M. L. Vestal, J. Am. Chem. Soc. 102, 5931 (1980).CrossRefGoogle Scholar
  66. 65.
    C. R. Blakley and M. L. Vestal, Anal. Chem. 55, 750 (1983).CrossRefGoogle Scholar
  67. 66.
    R. Shaw and W. H. Elliott, Lipids 13, 971 (1978).PubMedCrossRefGoogle Scholar
  68. 67.
    G. Mingrone, A. V. Greco, L. Boniforti, and S. Passi, Lipids 18, 90 (1983).PubMedCrossRefGoogle Scholar
  69. 68.
    S. Miyazaki, H. Tanaka, R. Horikawa, H. Tsuchiya, and K. Imai, J. Chromatogr. 181, 177 (1980).PubMedCrossRefGoogle Scholar
  70. 69.
    S. Okuyama, D. Uemura, and Y. Hirata, Chem. Lett. 461(1979).Google Scholar
  71. 70.
    F. Stellaard, D. L. Hachey, and P. D. Klein, Anal. Biochem. 87, 359 (1978).PubMedCrossRefGoogle Scholar
  72. 71.
    N. Parris, Anal. Biochem. 100, 260 (1979).PubMedCrossRefGoogle Scholar
  73. 72.
    J. Goto, H. Kato, and T. Nambara, Lipids 13, 908 (1978).PubMedCrossRefGoogle Scholar
  74. 73.
    J. Goto, H. Kato, and T. Nambara, J. Liq. Chromatogr. 3, 645 (1980).CrossRefGoogle Scholar
  75. 74.
    D. E. Games, C. Eckers, J. L. Gower, P. Hirter, M. E. Knight, E. Lewis, K. R. N. Rao, and N. C. Weerasinghe, in“Current Developments in the Clinical Applications of HPLC, GC and MS” (A. M. Lawson, C. K. Lim, and W. Richmond, eds.), Academic Press, London (1980).Google Scholar
  76. 75.
    A. Kuksis, in “Lipid Chromatographic Analysis. Gas Chromatography of Bile Acids,” Volume 2 (G. V. Marinetti, ed.), Dekker, New York, p. 479 (1976).Google Scholar
  77. 76.
    R. Galeazzi, E. Kok, and N. Javitt, J. Lipid Res. 17, 280 (1976).Google Scholar
  78. 77.
    I. M. Yousef, M. M. Fisher, J. J. Myher, and A. Kuksis, Anal. Biochem. 75, 538 (1976).PubMedCrossRefGoogle Scholar
  79. 78.
    P. A. Szczepanik, D. L. Hachey, and P. D. Klein, J. Lipid Res. 18, 280 (1978).Google Scholar
  80. 79.
    T. Nakashima, Y. Ban, K. Kuriyama, and T. Takino, Jpn. J. Pharmacol. 29, 667 (1979).PubMedCrossRefGoogle Scholar
  81. 80.
    T. Iida, F. C. Chang, T. Matsumoto, and T. Tamura, Biomed. Mass Spectrom. 9, 473 (1982).CrossRefGoogle Scholar
  82. 81.
    H. Budzikiewicz, in “Biomedical Applications of Mass Spectrometry” (G. R. Waller, ed.), p. 251, Wiley, New York (1972).Google Scholar
  83. 82.
    Z. C. Zaretskii, in“Mass Spectrometry of Steroids,” Wiley, New York (1976).Google Scholar
  84. 83.
    H. Budzikiewicz, in“Biomedical Applications of Mass Spectrometry,” First Supplementary Volume (G. R. Waller, and O. C. Dermer, eds.), p. 211, Wiley, New York, 1980.Google Scholar
  85. 84.
    T. Cronholm, I. Makino, and J. Sjövall, Eur. J. Biochem. 24, 507 (1972).PubMedCrossRefGoogle Scholar
  86. 85.
    T. Harano, K. Harano, and K. Yamasaki, Steroids 32, 73 (1978).PubMedCrossRefGoogle Scholar
  87. 86.
    H. Eriksson, W. Taylor, and J. Sjövall, J. Lipid Res. 19, 177 (1978).PubMedGoogle Scholar
  88. 87.
    L. Aringer, and L. Nordström, Biomed. Mass Spectrom. 8, 183 (1981).CrossRefGoogle Scholar
  89. 88.
    M. I. Kelsey, M. M. Mau, and W. H. Elliott, Steroids 18, 261 (1971).PubMedCrossRefGoogle Scholar
  90. 89.
    T. A. Baillie, H. Eriksson, J. E. Herz, and J. Sjövall, Eur. J. Biochem. 55, 157 (1975).PubMedCrossRefGoogle Scholar
  91. 90.
    F. Kern, Jr., H. Eriksson, T. Curstedt, and J. Sjövall, J. Lipid Res. 18, 623 (1977).PubMedGoogle Scholar
  92. 91.
    A. Bremmelgaard and J. Sjövall, J. Lipid Res. 21, 1072 (1980).PubMedGoogle Scholar
  93. 92.
    C. J. W. Brooks, W. J. Cole, H. B. Mclntyre, and A. G. Smith, Lipids 15, 745 (1980).PubMedCrossRefGoogle Scholar
  94. 93.
    B. Strandvik, and S-À. Wikström, Eur. J. Clin. Invest. 12, 301 (1982).PubMedCrossRefGoogle Scholar
  95. 94.
    P. Back and K. Walter, Gastroenterology 78, 671 (1980).PubMedGoogle Scholar
  96. 95.
    A. Bremmelgaard and J. Sjövall, Eur. J. Clin. Invest. 9, 341 (1979).PubMedCrossRefGoogle Scholar
  97. 96.
    K. Carlström, D. N. Kirk, and J. Sjövall, J. Lipid Res. 22, 1225 (1981).PubMedGoogle Scholar
  98. 97.
    B. Aimé and J. Sjövall, J. Steroid Biochem. 13, 907 (1980).CrossRefGoogle Scholar
  99. 98.
    P. T. Clayton, D. P. R. Müller, and A. M. Lawson, Biochem. J. 206, 489 (1982).PubMedGoogle Scholar
  100. 99.
    A. M. Lawson, K. D. R. Setchell, P. T. Clayton, and D. P. R. Muller, in Proceedings 31st Annual Conference Mass Spectrometry, Allied Topics, American Society of Mass Spectrometry, Boston, p. 510 (1983).Google Scholar
  101. 100.
    J. G. Allen, G. H. Thomas, C. J. W. Brooks, and B. A. Knights, Steroids 13, 133 (1969).PubMedCrossRefGoogle Scholar
  102. 101.
    M. Kimura, M. Kawata, M. Tohma, A. Fujino, K. Yamazaki, and T. Sawya, Chem. Pharm. Bull. 20, 1883 (1972).Google Scholar
  103. 102.
    S. V. Hiremath and W. H. Elliott, Steroids 38, 465 (1981).PubMedCrossRefGoogle Scholar
  104. 103.
    P. Child, A. Kuksis, and L. Marai, Can. J. Biochem. 57, 216 (1979).PubMedCrossRefGoogle Scholar
  105. 104.
    A. Kuksis and P. Child, Lipids 15, 770 (1980).PubMedCrossRefGoogle Scholar
  106. 105.
    P. T. Clayton, J. V. Leonard, A. M. Lawson, K. D. R. Setchell, S. Andersson, B. Egestadt, and J. Sjövall, J. Clin. Invest. 79, 1031 (1987).PubMedCrossRefGoogle Scholar
  107. 106.
    I. Makino, J. Sjövall, A. Norman, and B. Strandvik, FEBS Lett. 15, 161 (1971).PubMedCrossRefGoogle Scholar
  108. 107.
    C. J. W. Brooks, D. J. Harvey, B. S. Middleditch, and P. Vouros, Org. Mass Spectrom. 7, 925 (1973).CrossRefGoogle Scholar
  109. 108.
    I. Björkhem, J-A. Gustafsson, and J. Sjövall, Org. Mass Spectrom. 7, 277 (1973).CrossRefGoogle Scholar
  110. 109.
    A. Kallner, Acta Chem. Scand. 22, 2353 (1968).PubMedCrossRefGoogle Scholar
  111. 110.
    A. E. Cowen, A. F. Hofmann, D. L. Hachey, P. J. Thomas, D. T. E. Belobaba, P. D. Klein, and L. Tokes, J. Lipid Res. 17, 231 (1976).PubMedGoogle Scholar
  112. 111.
    Y. Shalen and W. H. Elliott, Steroids 28, 655 (1976).CrossRefGoogle Scholar
  113. 112.
    B. I. Cohen, G. S. Tint, T. Kuramoto, and E. H. Mosback, Steroids 25, 365 (1975).PubMedCrossRefGoogle Scholar
  114. 113.
    G. A. D. Haslewood, “The Biological Importance of Bile Salts,” North-Holland, Amsterdam (1978).Google Scholar
  115. 114.
    S. Y. Karmat and W. H. Elliott, Steroids 20, 279 (1972).CrossRefGoogle Scholar
  116. 115.
    I. G. Anderson, G. A. D. Haslewood, R. S. Oldham, B. Amos, and L. Tokes, Biochem. J. 141, 485 (1974).PubMedGoogle Scholar
  117. 116.
    R. F. Hanson, J. N. Isenberg, G. C. Williams, D. Hachey, P. Szczepanik, P. D. Klein, and H. L. Sharp, J. Clin. Invest. 56, 577 (1975).PubMedCrossRefGoogle Scholar
  118. 117.
    G. A. D. Haslewood, S. Ikawa, L. Tokes, and D. Wong, Biochem. J. 171, 409 (1978).PubMedGoogle Scholar
  119. 118.
    I. G. Anderson, T. Briggs, G. A. D. Haslewood, R. S. Oldham. H. Schuren, and L. Tokes, Biochem. J. 183, 507 (1979).PubMedGoogle Scholar
  120. 119.
    M. Une, N. Matsumoto, K. Kihira, M. Yasuhara, T. Kuramoto, and T. Hoshita, J. Lipid Res. 21, 269 (1980).PubMedGoogle Scholar
  121. 120.
    Y. Noma, M. Une, K. Kihira, M. Yashuda, T. Kuramoto, and T. Hoshita, J. Lipid Res. 21, 339 (1980).PubMedGoogle Scholar
  122. 121.
    M. Une, T. Kuramoto, and T. Hoshita, J. Lipid Res. 24, 1468 (1983).PubMedGoogle Scholar
  123. 122.
    G. S. Tint, B. Dayal, A. K. Batta, S. Shefer, T. Joanen, L. McNease, and G. Salen, J. Lipid Res. 21, 110 (1980).PubMedGoogle Scholar
  124. 123.
    G. S. Tint, B. Dayal, A. K. Batta, S. Shefer, T. Joanen, K. McNease, and G. Salen, Gastroenterology 80, 114 (1981).Google Scholar
  125. 124.
    S. S. Ali, E. Stephenson, and W. H. Elliott, J. Lipid Res. 23, 947 (1982).PubMedGoogle Scholar
  126. 125.
    K. Kihira, Y. Morioka, and H. Takahiko, J. Lipid Res. 22, 1181 (1981).PubMedGoogle Scholar
  127. 126.
    B. Amos, I. G. Anderson, G. A. D. Haslewood, and L. Tokes, Biochem. J. 161, 201 (1977).PubMedGoogle Scholar
  128. 127.
    R. F. Hanson and G. Williams, Biochem. J. 121, 863 (1971).PubMedGoogle Scholar
  129. 128.
    S. Y. Kamat and W. H. Elliott, Steroids 20, 279 (1972).PubMedCrossRefGoogle Scholar
  130. 129.
    M. M. Mui, S. Y. Kamat, and W. H. Elliott, Steroids 24, 239 (1974).PubMedCrossRefGoogle Scholar
  131. 130.
    T. Kuramoto, H. Kikuchi, H. Sanemori, and T. Hoshita, Chem. Pharm Bull. (Tokyo) 21, 952 (1973).Google Scholar
  132. 131.
    H. Eyssen, G. Parmentier, F. Compernolle, J. Boon, and E. Eggermont. Biochim. Biophys. Acta 273, 212 (1972).PubMedGoogle Scholar
  133. 132.
    J. Gustafsson, J. Biol. Chem. 250, 8243 (1975).PubMedGoogle Scholar
  134. 133.
    J. St. Pyrek, R. Lester, E. W. Adcock, and A. Sanghvi, J. Steroid Biochem. 18, 341 (1983).CrossRefGoogle Scholar
  135. 134.
    J. St. Pyrek, R. Sterzycki, R. Lester, and E. W. Adcock, Lipids 17, 241 (1982).CrossRefGoogle Scholar
  136. 135.
    J. M. Street, W. F. Balistreri, and K. D. R. Setchell, Gastroenterology 90, Abstract (1986).Google Scholar
  137. 136.
    J. St. Pyrek, J. M. Little, and R. Lester, J. Lipid Res. 25, 1324 (1984).Google Scholar
  138. 137.
    K. D. R. Setchell and A. Matsui, Clin. Chim. Acta, 127, 1 (1983).PubMedCrossRefGoogle Scholar
  139. 138.
    J. J. Myer, L. Marai, A. Kuksis, I. M. Yousef, and M. M. Fisher, Can. J. Biochem. 53, 583 (1975).CrossRefGoogle Scholar
  140. 139.
    P. Back, Hoppe-Seyler’s Z. Physiol. Chem. 357, 213 (1976).Google Scholar
  141. 140.
    P. Back and D. V. Bowen, Hoppe-Seyler’s Z. Physiol. Chem. 357, 219 (1976).PubMedCrossRefGoogle Scholar
  142. 141.
    G. Mingrone, A. V. Greco, L. Boniforti, and S. Passi, Lipids 18, 90 (1983).PubMedCrossRefGoogle Scholar
  143. 142.
    B. Aimé, A. Norden, and J. Sjövall, Clin. Chim. Acta 86, 251 (1978).CrossRefGoogle Scholar
  144. 143.
    I. M. Yousef and M. M. Fisher, Can. J. Physiol. Pharmacol. 53, 880 (1975).PubMedCrossRefGoogle Scholar
  145. 144.
    P. P. Nair, A. I. Mendeloff, M. Vocci, J. Bankowski, M. Gorelik, G. Herman, and R. Plapinger, Lipids 12, 922 (1977).PubMedCrossRefGoogle Scholar
  146. 145.
    J. Yanagisawa, Y. Akashi, H. Miyazaki, and F. Nakayama, J. Lipid Res. 25. 1263 (1984).PubMedGoogle Scholar
  147. 146.
    J. M. Street, D. J. H. Trafford, and H. L. J. Makin, J. Lipid Res. 27, 208 (1986).PubMedGoogle Scholar
  148. 147.
    K. D. R. Setchell, in “Proceedings of the 1st International Symposium on Bile Acids in Hepatobiliary Disease,” p. 63, IRL Press, Oxford, (1984).Google Scholar
  149. 148.
    R. Reimendal and J. Sjövall, Anal. Chem. 44, 21 (1972).PubMedCrossRefGoogle Scholar
  150. 149.
    P. Back. J. Sjövall, and K. Sjövall, Med. Biol. 52, 31 (1974).PubMedGoogle Scholar
  151. 150.
    P.A. Thomassen, Eur. J. Clin. Invest. 9, 425 (1979).PubMedCrossRefGoogle Scholar
  152. 151.
    A. Bremmelgaard and B. Aimé, Scand. J. Gastroenterol. 15, 593 (1980).PubMedCrossRefGoogle Scholar
  153. 152.
    H. Miyazaki, M. Ishibashi, M. Inone. M. Itoh, and T. Kubodera, J. Chromatogr. 99, 553 (1974).CrossRefGoogle Scholar
  154. 153.
    G. A. DeWeerdt, R. Beke, H. Verdievel, and F. Barbier, Biomed. Mass Spectrom. 7, 515 (1980).CrossRefGoogle Scholar
  155. 154.
    M. Axelson, T. Cronholm, T. Curstedt, R. Reimendal, and J. Sjövall, Chromatographia 7, 502 (1974).CrossRefGoogle Scholar
  156. 155.
    B. S. Middleditch and D. M. Desiderio, Anal. Chem. 45, 806 (1973).CrossRefGoogle Scholar
  157. 156.
    H. Miyazaki, M. Ishibashi, and K. Yamashita, Biomed. Mass Spectrom. 5, 469 (1978).PubMedCrossRefGoogle Scholar
  158. 157.
    S. H. G. Andersson and J. Sjövall, J. Chromatogr. 289, 195 (1984).PubMedCrossRefGoogle Scholar
  159. 158.
    Y. Nishikawa, K. Yamashita, M. Ishibashi, and H. Miyazaki, Chem. Pharm. Bull. 26, 2922 (1978).Google Scholar
  160. 159.
    J. B. Watkins, D. Ingall, P. Szczepanik, P. D. Klein, and R. Lester, N. Engl. J. Med. 288, 431 (1973).PubMedCrossRefGoogle Scholar
  161. 160.
    W. F. Balistreri, A. E. Cowen. A. F. Hofmann, P. A. Szczepanik, and P. D. Klein, Pediatr. Res. 9, 757 (1975).CrossRefGoogle Scholar
  162. 161.
    T. Tateyama, Y. Nezu, M. Shino, K. Sakaguchi, K. Katayama, and J. Tsutsumi, Koenshulyo Masu Kenkyukai 3, 207 (1978).Google Scholar
  163. 162.
    F. Kern, Jr., G. T. Everson, B. DeMark, C. McKinley, R. Showalter, W. Erfling, D. Z. Braverman, P. Sczcepanik-Van Leeuwen, and P. D. Klein, J. Clin. Invest. 68, 1229 (1981).PubMedCrossRefGoogle Scholar
  164. 163.
    G. Everson, B. DeMark, P. D. Klein. R. Showalter, C. McKinley, and F. Kern, Jr., Gastroenterology 80, 1114 (1981).Google Scholar
  165. 164.
    T. Nishida, H. Miwa, M. Yamamoto, T. Koga, and T. Yao, Gut 23, 751 (1982).PubMedCrossRefGoogle Scholar
  166. 165.
    B. R. DeMark, G. T. Everson. P. D. Klein, R. B. Showalter, and F. Kern, Jr., J. Lipid Res. 23, 204 (1982).PubMedGoogle Scholar
  167. 166.
    F. Stellaard, R. Schubert, and G. Paumgartner, Biomed. Mass Spectrom. 10, 187 (1983).PubMedCrossRefGoogle Scholar
  168. 167.
    T. Cronholm, A. L. Burlingame, and J. Sjövall, Eur. J. Biochem. 49, 497 (1974).PubMedCrossRefGoogle Scholar
  169. 168.
    T. Cronholm, I. Makino, and J. Sjövall, Eur. J. Biochem. 26, 251 (1972).PubMedCrossRefGoogle Scholar
  170. 169.
    T. Cronholm, H. Eriksson, S. Matern, and J. Sjövall, Eur. J. Biochem 53, 405 (1975).PubMedCrossRefGoogle Scholar
  171. 170.
    D. M. Wilson, A. L. Burlingame, S. Evans, T. Cronholm, and J. Sjövall, in “Stable Isotopes. Applications in Pharmacology, Toxicology and Clinical Research” (T. A. Baillie, ed.), p. 205, Macmillan, London (1978).Google Scholar
  172. 171.
    D. M. Wilson, A. L. Burlingame, D. Hazelby, S Evans, T. Cronholm, and J. Sjövall, Proceedings 25th Annual Conference Mass Spectrometry, Allied Topics, American Society of Mass Spectrometry, p. 357 (1977).Google Scholar
  173. 172.
    T. Cronholm, J. Sjövall, D. M. Wilson, and A. L. Burlingame, Biochim. Biophys. Acta 575, 193 (1979).PubMedGoogle Scholar
  174. 173.
    I. Björkhem and A. Lewenhaupt, J. Biol. Chem. 254, 5252 (1979).PubMedGoogle Scholar
  175. 174.
    T. Beppu, Y. Seyama, T. Kasama, and T. Yamakawa, J. Biochem. (Tokyo) 89, 1963 (1981).Google Scholar
  176. 175.
    B. Angelin and I. Björkhem, Gut 18, 606 (1977).PubMedCrossRefGoogle Scholar
  177. 176.
    B. Angelin, I. Björkhem, and K. Einarsson, J. Lipid Res. 19, 527 (1978).PubMedGoogle Scholar
  178. 177.
    J. Ahlberg, B. Angelin, I. Björkhem, and K. Einarsson, Gastroenterology 73, 1377 (1977).PubMedGoogle Scholar
  179. 178.
    I. Björkhem and O. Falk, Scand. J. Clin. Lab. Invest. 43, 163 (1983).PubMedGoogle Scholar
  180. 179.
    Y. Akashi, H. Miyazaki, and F. Nakayama, Clin. Chim. Acta 133, 125 (1983).PubMedCrossRefGoogle Scholar
  181. 180.
    H. Takikawa, H. Otsuka, T. Beppu, Y. Seyama, and T. Yamakawa, J. Biochem. (Tokyo) 92, 985 (1982).Google Scholar
  182. 181.
    M. Shino, Y. Nezu, T. Tateyama, K. Sakaguchi, K. Katayama, J. Tsutsumi, and K. Kawabe, Yakugaku Zasshi 99, 421 (1979).PubMedGoogle Scholar
  183. 182.
    I. Björkhem, B. Angelin, K. Einarsson, and S. Ewerth, J. Lipid Res. 23, 1020 (1982).PubMedGoogle Scholar
  184. 183.
    H. Takikawa, T. Beppu, Y. Seyama, and T. Wada, Gastroenterol. Jpn. 18, 246 (1983).PubMedGoogle Scholar
  185. 184.
    M. Tohma, Y. Nakata, H. Yamada, T. Kurosawa, I. Makino, and S. Nakagawa, Chem. Pharm. Bull. 29, 137 (1981).PubMedGoogle Scholar
  186. 185.
    F. Stellaard, M. Sackmann, T. Sauerbruch, and G. Paumgartner, J. Lipid Res. 25, 1313 (1984).PubMedGoogle Scholar
  187. 186.
    F. Stellaard and G. Paumgartner, Biomed. Mass Spectrom. 12, 560 (1985).PubMedCrossRefGoogle Scholar
  188. 187.
    F. Stellaard, G. Paumgartner, G. P. VanBerge Henegouwen, and S. D. J. Van der Werf, J. Lipid Res. 27, 1222 (1986).PubMedGoogle Scholar
  189. 188.
    T. C. Bartholomew, J. A. Summerfield, B. H. Billing, A. M. Lawson, and K. D. R. Setchell, Clin. Sci. 63, 65 (1982).PubMedGoogle Scholar
  190. 189.
    D. H. Sandberg, J. Sjövall, and D. A. Turner, J. Lipid Res. 6, 182 (1965).PubMedGoogle Scholar
  191. 190.
    I. Makino, S. Nakagawa, and K. Mashino, Gastroenterology 56, 1033 (1969).PubMedGoogle Scholar
  192. 191.
    K. D. R. Setchell, A. M. Lawson, E. J. Blackstock, and G. M. Murphy, Gut 23, 637 (1982).PubMedCrossRefGoogle Scholar
  193. 192.
    K. D. R. Setchell, D. L. Harrison, J. M. Gilbert, and G. M. Murphy, Clin. Chim. Acta 152, 297 (1985).PubMedCrossRefGoogle Scholar
  194. 193.
    J. A. Summerfield, B. H. Billing, and C. H. L. Shackleton, J. Biochem. 154, 507 (1976).Google Scholar
  195. 194.
    Y. Tazawa, M. Yamada, M. Nakagawa, T. Konno, and K. Tada, J. Pediatr. Gastroenterol. Nutr. 4, 32 (1985).PubMedCrossRefGoogle Scholar
  196. 195.
    S. Barnes, G. Berkowitz, I. Horschowitz, and D. Wirtschafter, J. Clin. Invest. 68, 775 (1981).PubMedCrossRefGoogle Scholar
  197. 196.
    F. J. Suchy, W. F. Balistreri, J. E. Heubi, J. E. Searcy, and R. S. Levin, Gastroenterology 80, 1037 (1981).PubMedGoogle Scholar
  198. 197.
    G. G. Parmentier, G. A. Janssen, E. A. Eggermont, and H. J. Eyssen, Eur. J. Biochem. 102, 173 (1979).PubMedCrossRefGoogle Scholar
  199. 198.
    G. Janssen and G. Parmentier, Steroids, 37, 81 (1981).PubMedCrossRefGoogle Scholar
  200. 199.
    G. Janssen, S. Toppet, and G. Parmentier, J. Lipid Res. 23, 453 (1982).Google Scholar
  201. 200.
    B. F. Kase, J. I. Pedersen, B. Strandvik, and I. Björkhem, J. Clin. Invest. 76, 2393 (1985).PubMedCrossRefGoogle Scholar
  202. 201.
    R. F. Hansson, P. Szczepanik-Van Leeuwen, G. C. Williams, G. Grabowski, and H. L. Sharp, Science 203, 1107 (1979).CrossRefGoogle Scholar
  203. 202.
    H. Eyssen, E. Eggermont, J. Van Eldere, J. Jaeken, G. Parmentier, and G. Janssen, Acta Pediatr. Scand. 74, 539 (1985).CrossRefGoogle Scholar
  204. 203.
    B. F. Kase, I. Bjorkhem, P. Haga, and J. I. Pedersen, J. Clin. Invest. 75, 427 (1985).PubMedCrossRefGoogle Scholar
  205. 204.
    A. Poulos, P. Sharp, A. J. Fellenberg, and D. M. Danks, Hum. Genet. 70, 172 (1985).PubMedCrossRefGoogle Scholar
  206. 205.
    A. Poulos and M. J. Whiting, J. Inker. Metab. Dis. 8, 13 (1985).CrossRefGoogle Scholar
  207. 206.
    J. M. Little, J. St. Pyrek, and R. Lester, J. Clin. Invest. 71, 73 (1983).PubMedCrossRefGoogle Scholar
  208. 207.
    K. Tanaka, K. Takeshita, and M. Takita, Clin. Sci. 62, 627 (1982).PubMedGoogle Scholar
  209. 208.
    K. D. R. Setchell and J. Worthington, Clin. Chim. Acta 125, 135 (1982).PubMedCrossRefGoogle Scholar
  210. 209.
    H. Takikawa, H. Otsuka, T. Beppu, Y. Seyama, and T. Yamakawa, Digestion 27, 189 (1983).PubMedCrossRefGoogle Scholar
  211. 210.
    H. Takikawa, T. Beppu, Y. Seyama, K. Obinata, and H. Nittono, Biochem. Med. 33, 381 (1985).PubMedCrossRefGoogle Scholar
  212. 211.
    H. Takikawa, T. Beppu, Y. Seyama, and T. Sugimoto, Dig. Dis Sci. 31, (1986).Google Scholar
  213. 212.
    M. Maeda, H. Ohama, H. Takeda, M. Yabe, M. Nambu, and T. Namihisa, J. Lipid Res. 25, 14 (1984).PubMedGoogle Scholar
  214. 213.
    G. Hedenborg and A. Norman, Scand. J. Clin. Lab Invest. 45, 151 (1985).PubMedCrossRefGoogle Scholar
  215. 214.
    M. Tohma, H. Wajima, R. Mahara, T. Kurosawa, and I. Makino, Steroids 44, 47 (1984).PubMedCrossRefGoogle Scholar
  216. 215.
    S. Barnes and A. Chitranukroh, Ann. Clin. Biochem. 14, 235 (1977).PubMedGoogle Scholar
  217. 216.
    J.F. Pageaux, B. Duperray, D. Anker, and M. Dubois, Steroids 34, 73 (1979).PubMedCrossRefGoogle Scholar
  218. 217.
    K. D. R. Setchell, in“Bile Acids in Gastroenterology” (L. Barbara, R. H. Dowling, A. F. Hofmann, and E. Roda, eds.). p. 1, MTP Press, Lancaster, England (1982).Google Scholar
  219. 218.
    J. Goto, M. Hasegawa, H. Kato, and T. Nambara, Clin. Chim. Acta 70, 141 (1978).Google Scholar
  220. 219.
    T. Beppu, Y. Seyama, T. Kasama, S. Serizawa, and T. Yamakawa, Clin. Chim. Acta 70, 141 (1978).Google Scholar
  221. 220.
    R. Tandon, M. Axelson, and J. Sjovall, J. Chromatogr. 302, 1 (1984).PubMedCrossRefGoogle Scholar
  222. 221.
    D. L. Hachey, P. A. Szczepanik. O. W. Berngruber, and P. D. Klein, J. Labelled Compd. 9, 703 (1973).CrossRefGoogle Scholar
  223. 222.
    K-Y. Tserng and P. D. Klein, J. Lipid Res. 18, 400 (1977).PubMedGoogle Scholar
  224. 223.
    T. A. Baillie, M. Karls, and J. Sjovall, J. Labelled Compd. Radiopharm. 14, 849 (1978).CrossRefGoogle Scholar
  225. 224.
    S. Lindstedt, Acta Chem. Scand. 11, 417 (1957).CrossRefGoogle Scholar
  226. 225.
    P. D. Klein, J. R. Haumann, and W. J. Eisler, Clin Chim. 17, 735 (1971).Google Scholar
  227. 226.
    P. D. Klein, J. R. Haumann, and W. J. Eisler, Clin. Chim. 21, 1253 (1975).Google Scholar
  228. 227.
    A. F. Hofmann and S. A. Cummings, in“Bile Acids in Gastroenterology” (L. Barbara, R. H. Dowling, A. F. Hofmann, and E. Roda, eds.), MTP Press. Boston, p. 75 (1982).Google Scholar
  229. 228.
    I. M. Campbell, Bioorg. Chem. 3, 386 (1974).CrossRefGoogle Scholar
  230. 229.
    J. Sjovall, Clin. Chim. Acta 4, 652 (1959).CrossRefGoogle Scholar
  231. 230.
    J. Sjovall, Proc. Soc. Exp. Biol. Med. 100, 676 (1959).PubMedGoogle Scholar
  232. 231.
    J. Sjovall, Clin. Chim. Acta 5, 33 (1960).CrossRefGoogle Scholar
  233. 232.
    R. G. Danzinger, A. F. Hofmann, L. J. Schoenfield, O. W. Berngruber, P. A. Szczepanik, and P. D. Klein, Gastroenterology 60, 192 (1971).Google Scholar
  234. 233.
    P. D. Klein, J. R. Haumann, and D. L. Hachey, J. Lipid Res. 22, 166 (1981).PubMedGoogle Scholar
  235. 234.
    E. J. Norman, J. E. Heubi, M. J. Gelfand, P. Dan, and D. W. Matthews, Biomed. Mass Spectrom. 11, 269 (1984).PubMedCrossRefGoogle Scholar
  236. 235.
    G. Hedenborg, A. Norlander, and A. Norman, Scand. J. Clin. Lab. Invest. 42, 551 (1982).PubMedCrossRefGoogle Scholar
  237. 236.
    G. Hedenborg, A. Norlander, and A. Norman, Scand. J. Clin. Lab. Invest. 45, 157 (1985).PubMedCrossRefGoogle Scholar
  238. 237.
    A. Stiehl, R. Raedsch, G. Rudolph, V. Gundert-Remy, and M. Senn, Hepatology 5, 492 (1985).PubMedCrossRefGoogle Scholar
  239. 238.
    F. Stellaard, P. D. Klein, A. F. Hofmann, and J. M. Lachlin, J. Lab. Clin. Med. 105, 504 (1985).PubMedGoogle Scholar
  240. 239.
    G. M. Murphy and E. Singer, Gut 15, 151 (1974).PubMedCrossRefGoogle Scholar
  241. 240.
    R. Lester, J. St. Pyrek, J. M. Little, and E. W. Adcock, J. Pediatr. Gastroenterol. Nutr. 2, 355 (1983).PubMedGoogle Scholar
  242. 241.
    C. Colombo, G. Zuliani, M. Ronchi, J. Breidenstein, and K. D. R. Setchell, Pediatr. Res. 21, 197 (1987).PubMedCrossRefGoogle Scholar
  243. 242.
    H. L. Sharpe, J. Peller, J. B. Carey Jr., and W. Krivitt, Pediatr. Res. 5, 279 (1971).Google Scholar
  244. 243.
    P. Back and K. Ross, Hoppe-Seyle’s Z. Physiol Chem. 354, 83 (1973).CrossRefGoogle Scholar
  245. 244.
    J. Gustafsson, J. Clin. Invest. 75, 604 (1985).PubMedCrossRefGoogle Scholar
  246. 245.
    J. Gustafsson, Biol. Neonate 47, 26 (1985).PubMedCrossRefGoogle Scholar
  247. 246.
    A. M. Bongiovanni, J. Clin. Endocr. 25, 678 (1965).PubMedCrossRefGoogle Scholar
  248. 247.
    J. R. Poley, J. C. Dower, C. A. Owen, and G. B. Stickler, J. Lab. Clin. Med. 63, 838 (1964).PubMedGoogle Scholar
  249. 248.
    J. C. Encrantz and J. Sjövall, Clin. Chim. Acta 4, 793 (1959).PubMedCrossRefGoogle Scholar
  250. 249.
    P. Eneroth, B. Gordon, R. Ryhage, and J. Sjövall, J. Lipid Res. 7, 511 (1966).PubMedGoogle Scholar
  251. 250.
    P. Eneroth, B. Gordon, and J. Sjövall, J. Lipid Res. 7, 524 (1966).PubMedGoogle Scholar
  252. 251.
    P. Eneroth, K. Hellstrom, and J. Sjövall, Acta Chem. Scand. 22, 1729 (1968).PubMedCrossRefGoogle Scholar
  253. 252.
    K. D. R. Setchell, A. M. Lawson, N. Tanida, and J. Sjövall, J. Lipid Res. 24, 1085 (1983).PubMedGoogle Scholar
  254. 253.
    G. A. DeWeerdt, R. Beke, and F. Barbier, Biomed. Mass Spectrom. 7, 515 (1980).CrossRefGoogle Scholar
  255. 254.
    N. Tanida, Y. Hikasa, M. Hosomi, M. Satomi, I. Oohama, and T Shimoyama, Gastroenterol. Jpn. 16, 363 (1981).PubMedGoogle Scholar
  256. 255.
    N. Tanida, Y. Hikasa, T. Shimoyama, and K. D. R. Setchell, Gut 25, 824 (1982).CrossRefGoogle Scholar
  257. 256.
    K. D. R. Setchell, J. M. Gilbert, and A. M. Lawson, Br. Med. J. 286, 1750 (1983).CrossRefGoogle Scholar
  258. 257.
    Y. Hikasa, N. Tanida. T. Ohno, and T. Shimoyama, Gut 25, 833 (1984).PubMedCrossRefGoogle Scholar
  259. 258.
    G. A. DeWeerdt, H. Verdievel, R. Beke, and F. Barbier, in“Proceedings of the 1st International Symposium on Bile Acids in Hepatobiliary and Gastrointestinal Disease,” p. 185, IRL Press, Oxford (1984).Google Scholar
  260. 259.
    N. Tanida, Y. Hikasa, T. Shimoyama, and K. D. R. Setchell, Jpn. J. Cancer Res. (Gann) 76, 104 (1985).PubMedGoogle Scholar
  261. 260.
    J. M. Gilbert, K. D. R. Setchell, A. M. Lawson, and P. Royston, Eur. J. Surg. Oncol. 12, 359 (1986).PubMedGoogle Scholar
  262. 261.
    K. D. R. Setchell, J. A. Ives, G. C. Cashmore, and A. M. Lawson, Clin. Chim. Acta 162, 257 (1987).PubMedCrossRefGoogle Scholar
  263. 262.
    M. T. Podesta, G. M. Murphy, G. E Sladen, N. F. Breuer, and R. H. Dowling, in“Biological Effects of Bile Acids” (G. Paumgartner, A. Stiehl, and W. Gerok, eds.), p. 245, MTP Press, Lancaster, England (1978).Google Scholar
  264. 263.
    M. T. Podesta, G. M. Murphy, and R. H. Dowling, Clin. Chim. Acta 182, 243 (1980).Google Scholar
  265. 264.
    A. Norman and R. H. Palmer, J. Lab Clin. Med. 63, 986 (1964).PubMedGoogle Scholar
  266. 265.
    M. I. Kelsey and S. A. Sexton, J. Chromatogr. 133, 327 (1977).PubMedCrossRefGoogle Scholar
  267. 266.
    M. I. Kelsey and S. A. Sexton, J. Steroid Biochem. 7, 641 (1976).PubMedCrossRefGoogle Scholar
  268. 267.
    M. I. Kelsey, J. E. Molina, S-K. S. Huang, and K-K. Huang, J. Lipid Res. 21, 751 (1980).PubMedGoogle Scholar
  269. 268.
    M. Malavolti, H. Fromm, B. Cohen, and S. Ceryak, J. Biol. Chem. 260, 11011 (1985).PubMedGoogle Scholar
  270. 269.
    W. C. Duane, J. C. Behrens, S. G. Kelly, and A. S. Levine, J. Lipid Res. 25, 523 (1984).PubMedGoogle Scholar
  271. 270.
    P. Back, J. Sjövall, and K. Sjövall, Scand. J. Clin. Lab. Invest. 29, (Suppl. 126) (1972).Google Scholar
  272. 271.
    P. Back and K. Ross, Hoppe-Seyler’s Z. Physiol. Chem. 354, 83 (1973).PubMedCrossRefGoogle Scholar
  273. 272.
    T. J. Laatikainen, P. J. Lehtonen, and A. E. Hesso, J. Lab. Clin. Med. 92, 185 (1978).PubMedGoogle Scholar
  274. 273.
    G. Déléze, G. Paumgartner, G. Karlaganis, W. Giger, M. Reinhard, and D. Sidiropoulos, Eur. J. Clin. Invest. 8, 41 (1978).PubMedCrossRefGoogle Scholar
  275. 274.
    J. Goto, K. Suzaki, M. Ebihara, and T. Nambara, Clin. Chim. Acta 345, 241 (1985).Google Scholar
  276. 275.
    J. A. Summerfield, J. Gollan, and B. H. Billing, Biochem. J. 156, 339 (1976).PubMedGoogle Scholar
  277. 276.
    J. A. Summerfield, J. Cullen, S. Barnes, and B. H. Billing, Clin. Sci. Mol. Med. 52, 51 (1977).PubMedGoogle Scholar
  278. 277.
    W. Frohling and A. Stiehl, Eur. J. Clin. Invest. 9, 67 (1976).CrossRefGoogle Scholar
  279. 278.
    K. D. R. Setchell, B. Aimé, M. Axelson, and J. Sjövall, J. Steroid Biochem. 7, 615 (1976).PubMedCrossRefGoogle Scholar
  280. 279.
    A. Stiehl, R. Raedsch, G. Rudolf, P. Czygan, and S. Walker, Clin. Chim. Acta 123, 275(1982).PubMedCrossRefGoogle Scholar
  281. 280.
    A. Radominska-Pyrek, P. Zimniak, M. Chari, E. Golunski, R. Lester, and J. St. Pyrek, J. Lipid Res. 27, 89 (1986).PubMedGoogle Scholar
  282. 281.
    P. Back, Clin. Chim. Acta 44, 199 (1973).PubMedCrossRefGoogle Scholar
  283. 282.
    P. Back, K. Spaczynski, and W. Gerok, Hoppe-Seyler’s Z. Physiol. Chem. 355, 749 (1974).PubMedGoogle Scholar
  284. 283.
    A. Stiehl, in “Clinics in Gastroenterology” (G. Paumgartner, ed.), p. 45, Saunders. London, Philadelphia, Toronto (1977).Google Scholar
  285. 284.
    K. D. R. Setchell and J. M. Street, Semin. Liver Dis. 7, 85 (1987).PubMedCrossRefGoogle Scholar
  286. 285.
    G. P. VanBerge-Henegouwen, K-H. Brandt, H. Eyssen, and G. Parmentier, Gut 17, 861 (1976).CrossRefGoogle Scholar
  287. 286.
    B. Aimé, A. Bremmelgaard, J. Sjövall, and P. Thomassen, in “Advances in Bile Acid Research” (S. Matern, J. Hackenschmidt, P. Back, and W. Gerok, eds.), p. 145, F. K. Schattanen Verlag, Stuttgart (1974).Google Scholar
  288. 287.
    Y. Amuro, E. Hayashi, T. Endo, K. Higashino, K. Uchida, and Y. Yamamura, Gastroenterol. Jpn. 16, 506 (1981).PubMedGoogle Scholar
  289. 288.
    Y. Amuro, E. Hayashi, T. Endo, K. Higashino, and S. Kishimoto, Clin. Chim. Acta 127, 61 (1983).PubMedCrossRefGoogle Scholar
  290. 289.
    G. Karlaganis, V. Karlaganis, and J. Sjövall, J. Lipid Res. 25, 693 (1984).PubMedGoogle Scholar
  291. 290.
    I. Björkhem, H. Oftebro, S. Skrede, and J. Pedersen, J. Lipid Res. 22, 191 (1981).PubMedGoogle Scholar
  292. 291.
    B. Egestad, P. Pettersson, S. Skrede, and J. Sjövall, Scand. J. Clin. Invest. 45, 443 (1985).PubMedCrossRefGoogle Scholar
  293. 292.
    J. Gustafsson, K-H. Gustavson, G. Karlaganis, and J. Sjövall, Clin. Genet. 24, 313 (1983).PubMedGoogle Scholar
  294. 293.
    A. M. Lawson, M. J. Madigan, D. Shortland, and P. T. Clayton, Clin. Chim. Acta 161, 221 (1986).PubMedCrossRefGoogle Scholar
  295. 294.
    P. T. Clayton, A. M. Lawson, K. D. R. Setchell, S. Anderson, B. Egestad, and J. Sjövall, in “Bile Acids and the Liver,” (G. Paumgartner, A. Stiehl, and W. Gerok, eds.), p. 259, MTP Press, Lancaster, England (1987).Google Scholar
  296. 295.
    J. Yanagisawa, H. Ichimiya, M. Nagai, and F. Nakayama, J. Lipid Res. 25, 750 (1984).PubMedGoogle Scholar
  297. 296.
    J. Dupont, in “The Bile Acids,” Volume 1 (P. P. Nair and D. Kritchevsky, eds.), Plenum Press, New York.Google Scholar
  298. 297.
    P. P. Nair, R. Solomon, J. Bankowski, and R. Plapinger, Lipids 12, 922 (1978).CrossRefGoogle Scholar
  299. 298.
    T. Okishio, P. P. Nair, and M. Gordon, Biochem. J. 102, 654 (1967).PubMedGoogle Scholar
  300. 299.
    A. M. Gelb, C. K. McSherry, J. R. Sadowsky, and E. H. Mosbach, Am. J Gastroenterol. 77, 314 (1982).PubMedGoogle Scholar
  301. 300.
    J. Yanagisawa, M. Itoh, M. Ishibashi, H. Miyazaki, and F. Nakayama, Anal. Biochem. 107, 75 (1980).CrossRefGoogle Scholar
  302. 301.
    P. P. Nair, G. Kessie, and V. P. Flanagan, J. Lipid Res. 27, 905 (1986).PubMedGoogle Scholar
  303. 302.
    N. Turjman and P. P. Nair, Cancer Res. 41, 3761 (1981).PubMedGoogle Scholar
  304. 303.
    P. T. Clayton, B. D. Lake, N. A. Hall, D. M. Shortland, R. A. Carruthers, and A. M. Lawson, Eur. J. Pedriatr. 146, 166 (1987).CrossRefGoogle Scholar
  305. 304.
    A. M. Lawson, M. J. Madigan, and P. T. Clayton, in “Bile Acids and the Liver,” (G. Paumgartner, A. Stiehl, and W. Gerok, eds.), p. 269, MTP Press, Lancaster, England (1987).Google Scholar
  306. 305.
    C. D. Schteingart, L. R. Hagey. and A. F. Hofmann, Hepatology, 7, 1108 (1987).Google Scholar
  307. 306.
    C. D. Schteingart, L. R. Hagey. A. F. Hofmann, and K. D. R. Setchell, in “Proceedings of the 10th Bile Acid Meeting” Freiburg, W. Germany (June 9–11, 1988) (submitted).Google Scholar
  308. 307.
    B. J. Koopman, B. G. Wolthers, J. C. van der Molen, G. T. Nagel, and W Kruizinga, Biochim. Biophys. Acta 917, 238 (1987).PubMedGoogle Scholar
  309. 308.
    K. D. R. Setchell, and R. Dumaswala, in “Proceedings of the 10th Bile Acid Meeting,” Freiburg, W. Germany (June 9–11, 1988) (submitted).Google Scholar
  310. 309.
    K. D. R. Setchell, R. Dumaswala. C. Colombo, and M. Ronchi, J. Biol. Chem.(1988) (submitted).Google Scholar
  311. 310.
    K. D. R. Setchell, F. J. Suchy, M. B. Welsh, L. Zimmer-Nechemias, W. F. Balistreri, Gastroenterology(1988) (in press).Google Scholar
  312. 311.
    K. D. R. Setchell, F. J. Suchy, M. B. Welsh, L. Zimmer-Nechemias, J. Heubi, W. F. Balistreri, J. Clin. Invest. (1988) (submitted).Google Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • A. M. Lawson
    • 1
  • K. D. R. Setchell
    • 2
  1. 1.Section of Clinical Mass SpectrometryClinical Research CentreHarrow, MiddlesexEngland
  2. 2.Department of Pediatric Gastroenterology and Nutrition, Clinical Mass Spectrometry LaboratoriesChildren’s Hospital Medical CenterCincinnatiUSA

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