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Contractile Proteins of Smooth Muscle

  • Chapter
Physiology and Pathophysiology of the Heart

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 90))

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Abstract

The mechanism of contraction of smooth muscle is generally believed to be fundamentally the same as that of skeletal and cardiac muscles, i.e.,contraction occurs according to the crossbridge cycling-sliding filament model whereby thick and thin filaments slide relative to one another at the expense of ATP hydrolysis {1}This conclusion has come largely from ultrastructural studies of a variety of different smooth muscles{2}At the molecular level, the contractile apparatus of smoth muscle consist of the contractile proteins (actin and myosin, which are organized into thin and thick filaments, respectively) and associated regularly proteins (tropomyosin,myosin light-chain kinase, calmodulin,myosin light-chain phosphatase, and caldesmon).The tissue contents of actin,myosin, and tropomyosin in various smooth-muscle tissues have been discussed by Hartshorne{3}. In general,smooth muscles contain less myosin and more actin and tropomyosin than do skeletal muscles (table 42–1).

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  1. Department of Physiology and Biophysics and College of Medicine, University of Cincinnati, 231 Bethesda Avenue, 45267-0579, Cincinnati, OH, USA

    Nicholas Sperelakis

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Walsh, M.P. (1989). Contractile Proteins of Smooth Muscle. In: Sperelakis, N. (eds) Physiology and Pathophysiology of the Heart. Developments in Cardiovascular Medicine, vol 90. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0873-7_42

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