Substrate and Energy Metabolism of the Heart

  • L. H. Opie
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 90)


The purpose of the energy metabolism of the heart is to provide an adequate supply of high-energy phosphate compounds to replace the continuous use of ATP in contraction, in ionic exchange processes, and, to a lesser extent, in other energy-demanding processes. Because of the very high turnover rate of ATP in the myocardium, a correspondingly high rate of mitochondrial production of ATP is required. Within the mitochondria, the citrate cycle of Krebs breaks down the critical compound acetyl CoA to C02 and hydrogen atoms; the latter in turn yield electrons that are conveyed along the electron transmitter chain to yield ATP by oxidative phosphorylation, before finally combining with oxygen to form water.


Free Fatty Acid Pyruvate Dehydrogenase Glycolytic Flux Adenine Nucleotide Translocase Citrate Cycle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Kluwer Academic Publishers 1989

Authors and Affiliations

  • L. H. Opie

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