Premises for an Antioxidant Therapy in Pregnancy Induced Nephropathy
Different experimental and clinical observations support an imbalance between oxidant and anti oxidant factors in preeclampsia (PE): a) an increased concentration of lipid peroxides, and byproducts of peroxidation due to free-radicals (1); b) a reduced ability to produce Prostacyclin by the fetal and maternal endothelial cells (2); c) the preeclamptic-like syndrome induced in pregnant rat by a vitamin E deficient diet (3); d) the directly reduced placental Prostacyclin production due to a deficit of Vitamin E (4).
KeywordsUric Acid Serum Uric Acid Normal Pregnancy Total Serum Protein Plasma Vitamin
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