Premises for an Antioxidant Therapy in Pregnancy Induced Nephropathy

  • P. Stratta
  • C. Canavese
  • L. Gurioli
  • M. Porcu
  • M. Dogliani
  • F. Belliardo
  • E. Garbo
  • G. Artuffo
  • A. Vercellone
Part of the Developments in Nephrology book series (DINE, volume 24)

Abstract

Different experimental and clinical observations support an imbalance between oxidant and anti oxidant factors in preeclampsia (PE): a) an increased concentration of lipid peroxides, and byproducts of peroxidation due to free-radicals (1); b) a reduced ability to produce Prostacyclin by the fetal and maternal endothelial cells (2); c) the preeclamptic-like syndrome induced in pregnant rat by a vitamin E deficient diet (3); d) the directly reduced placental Prostacyclin production due to a deficit of Vitamin E (4).

Keywords

Peroxide HPLC Transferrin Preeclampsia Prostacyclin 

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Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • P. Stratta
    • 1
  • C. Canavese
    • 1
  • L. Gurioli
    • 1
  • M. Porcu
    • 1
  • M. Dogliani
    • 1
  • F. Belliardo
    • 2
  • E. Garbo
    • 2
  • G. Artuffo
    • 2
  • A. Vercellone
    • 1
  1. 1.Department of NephrologyUniversity of TorinoItaly
  2. 2.Department of Science and Tecnology of DrugsUniversity of TorinoItaly

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