Premises for an Antioxidant Therapy in Pregnancy Induced Nephropathy
Different experimental and clinical observations support an imbalance between oxidant and anti oxidant factors in preeclampsia (PE): a) an increased concentration of lipid peroxides, and byproducts of peroxidation due to free-radicals (1); b) a reduced ability to produce Prostacyclin by the fetal and maternal endothelial cells (2); c) the preeclamptic-like syndrome induced in pregnant rat by a vitamin E deficient diet (3); d) the directly reduced placental Prostacyclin production due to a deficit of Vitamin E (4).
KeywordsPeroxide HPLC Transferrin Preeclampsia Prostacyclin
Unable to display preview. Download preview PDF.
- 7).Oian, P., Maltau, J.M., Noddelan, H., Fadnes, H.O. Gynaecol 93: 235–239, 1986Google Scholar