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Ciclosporin a Therapy in Nephrotic Adults

  • M. Laville
  • E. Boussema
  • J. Finaz
  • O. Madonna
  • S. Colon
  • M. Labeeuw
  • P. Zech
Part of the Developments in Nephrology book series (DINE, volume 24)

Abstract

The effects of Ciclosporin A (CsA) upon lymphokine production by activated T-lymphocytes (1) had raised its clinical use for the treatment of steroid-resistant idiopathic nephrotic syndromes (NS), which account in adults for about 20% of minimal change glomerulonephritis (MCGN), 65% of focal glomerulosclerosis (FGS) and 35% of membranous glomerulonephritis (MGN) (2, 3, 4). With regards to the encouraging results reported in these glomerulopathies from several pilot studies (5, 6, 7), and the absence of clinically relevant nephrotoxicity we observed in lupus patients treated by CsA for at least 10 months (8), we started in May 1986 to treat steroid-resistant NS by CsA (as a part of multicentric trials involving most of Nephrology centers in France).

Keywords

Nephrotic Syndrome Partial Remission Idiopathic Nephrotic Syndrome Lupus Patient Nephrotic Syndrome Minimal Change 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • M. Laville
    • 1
  • E. Boussema
    • 1
  • J. Finaz
    • 1
  • O. Madonna
    • 1
  • S. Colon
    • 1
  • M. Labeeuw
    • 1
  • P. Zech
    • 1
  1. 1.Département de NéphrologieUniversité Claude-Bernard-Lyon I, Hôpital Edouard-HerriotLyonFrance

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