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Cyclosporin A — H2 Receptor Antagonists Drug Interaction in the Sprague-Dawley Rat

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Current Therapy in Nephrology

Part of the book series: Developments in Nephrology ((DINE,volume 24))

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Abstract

The H2 receptor antagonists (H2ra) such as cimetidine (C), ranitidine (R), and famotidine (F) seem to be effective in the prevention and treatment of stress ulcer in transplant recipients receiving cyclosporin A (CyA). A major problem in the management of these patients is to define the possible influence of H2ra on CyA metabolism and the possible synergistic nephro- and hepatotoxicity of these drugs, when co-administered (1). The aim of this research was to study the possible interaction between CyA, on one hand, and C, R, and F, on the other hand by evaluating the serum creatinine (SC), the serum alanine aminotransferase (ALT), the serum aspartate aminotransferase (AST) levels in experimental rats, in order to determine whether H2ra may be used with CyA without risk. Histological observations of the liver and kidneys of all rats studied were performed at the end of the experimental period.

THIS WORK WAS SUPPORTED IN PART BY CNR GRANT No. 86.00598.44.

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References

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Authors and Affiliations

  1. Clinica Medica, University of L’Aquila, L’Aquila, Italy

    R. Giacomelli, G. Famularo, S. Sacchetti & G. Tonietti

  2. Patologia Clinica, University of L’Aquila, L’Aquila, Italy

    A. Calogero & R. Verna

  3. Clinica Chirurgic, University of Rome ‘Tor Vergata’, L’Aquila, Italy

    V. Filingeri, F. Stortoni, S. Nardi, R. Rosati, V. Cervelli & C. U. Casciani

  4. Ist. Tipizz. Tessutale CNR, L’Aquila, Italy

    A. Iacona

Authors
  1. R. Giacomelli
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  2. V. Filingeri
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  3. G. Famularo
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  4. A. Calogero
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  5. F. Stortoni
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  6. S. Nardi
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  7. R. Rosati
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  8. A. Iacona
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  9. S. Sacchetti
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  10. V. Cervelli
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  11. R. Verna
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  12. G. Tonietti
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  13. C. U. Casciani
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Editor information

Editors and Affiliations

  1. Department of Nephrology, University of Naples, Naples, Italy

    Vittorio E. Andreucci M.D.  & Antonio Dal Canton M.D.  & 

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© 1989 Kluwer Academic Publishers

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Giacomelli, R. et al. (1989). Cyclosporin A — H2 Receptor Antagonists Drug Interaction in the Sprague-Dawley Rat. In: Andreucci, V.E., Dal Canton, A. (eds) Current Therapy in Nephrology. Developments in Nephrology, vol 24. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0865-2_138

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  • DOI: https://doi.org/10.1007/978-1-4613-0865-2_138

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8209-9

  • Online ISBN: 978-1-4613-0865-2

  • eBook Packages: Springer Book Archive

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