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Interaction of Calcium Antagonists and Ciclosporine A

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Current Therapy in Nephrology

Part of the book series: Developments in Nephrology ((DINE,volume 24))

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Abstract

Our group has previously demonstrated that the combined treatment of donor and recipient with the calcium antagonist (CA) diltiazem (Dil) reduced the incidence of delayed graft function in cadaveric kidney transplants, although significantly elevated ciclosporine A (CsA) whole-blood trough levels were observed (1). This first observation of an interaction of Dil and CsA induced us to investigate in a retrospective study the influence of initiation or discontinuation of Dil and nifedipine (Nif) on CsA therapy. In a second prospective clinical trial, the effect of Dil on kidney graft function and CsA pharmacokinetics was investigated in patients with stable graft function to elucidate possible mechanisms of this interaction.

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References

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Author information

Authors and Affiliations

  1. Departments of Internal Medicine, Klinikum Steglitz, Freie Universität Berlin, Federal Republic of Germany

    H.-H Neumayer, U. Kunzendorf & K. Wagner

  2. Clinical Pharmacology, Klinikum Steglitz, Freie Universität Berlin, Federal Republic of Germany

    J. Brockmöller, G. Heinemeyer & I. Roots

Authors
  1. H.-H Neumayer
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  2. J. Brockmöller
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  3. G. Heinemeyer
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  4. U. Kunzendorf
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  5. I. Roots
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  6. K. Wagner
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Editor information

Editors and Affiliations

  1. Department of Nephrology, University of Naples, Naples, Italy

    Vittorio E. Andreucci M.D.  & Antonio Dal Canton M.D.  & 

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© 1989 Kluwer Academic Publishers

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Neumayer, HH., Brockmöller, J., Heinemeyer, G., Kunzendorf, U., Roots, I., Wagner, K. (1989). Interaction of Calcium Antagonists and Ciclosporine A. In: Andreucci, V.E., Dal Canton, A. (eds) Current Therapy in Nephrology. Developments in Nephrology, vol 24. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0865-2_137

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  • DOI: https://doi.org/10.1007/978-1-4613-0865-2_137

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8209-9

  • Online ISBN: 978-1-4613-0865-2

  • eBook Packages: Springer Book Archive

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