In-Vitro Study of T Lymphocyte Activation in IgA Nephropathy (GN)
Recent studies have suggested a defective T lymphocyte immunoregulatory function in patients with IgA GN (1). The human lymphocytic interleukin-2 receptor [IL-2R] plays a critical role in the growth of T cells and is required for full expression of the normal immune response (2). The present study was undertaken to examine the in-vitro expression of IL-2R in T lymphocytes in patients with IgA GN. In addition, the effect of cyclosporin A (CyA), a fungal peptide that inhibits activation of T lymphocytes, on the expression of IL-2R was studied in patients with IgA GN.
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