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Pulse Therapy with Cyclophosphamide in Primary and Sistemic Glomerulopathy Resistant to Steroid Treatment

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Current Therapy in Nephrology

Part of the book series: Developments in Nephrology ((DINE,volume 24))

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Abstract

If the addition of cytotoxic agents to methyilprednisolone pulse therapy improves survival and morbidity in systemic nephrites is controversial (1,2). Intermittent boluses of cyclophosphamide have been shown to reduce the adverse effects observed with daily chronic administration (3,4,5,6). To our knowledge, cyclophosphamide pulse therapy has never been tested on idiopathic glomerulonephropathy with or without nephrotic syndrome.

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References

  1. Cameron, J.S. In: 9th Int. Congress Nephrology (Eds R.R. Robinson), Springer-Verlag, Los Angeles 1984, pp. 1445–1463.

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  2. Bolton, W.K. In: 9th Int. Congress Nephrology (Eds. R.T.Robinson), Springer-Verlag, Los Angeles 1984, pp. 1464–1473.

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  3. Steinberg, A.D. N. Engl. J. Med. 310:458, 1984.

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© 1989 Kluwer Academic Publishers

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Grekas, D., Kalekou, H., Karkavelas, G., Settas, L., Alivanis, P., Pyrpasopoulos, M. (1989). Pulse Therapy with Cyclophosphamide in Primary and Sistemic Glomerulopathy Resistant to Steroid Treatment. In: Andreucci, V.E., Dal Canton, A. (eds) Current Therapy in Nephrology. Developments in Nephrology, vol 24. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0865-2_10

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  • DOI: https://doi.org/10.1007/978-1-4613-0865-2_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8209-9

  • Online ISBN: 978-1-4613-0865-2

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