Guanidines 2 pp 303-311 | Cite as

Urinary Guanidinoacetic Acid Excretion as an Indicator of Gentamicin Nephrotoxicity in Rats

  • Shuei Nakayama
  • Masahiro Junen
  • Ikuo Kiyatake
  • Hikaru Koide


Guanidinoacetic acid (GAA) is a guanidino compound which is formed from arginine in the presence of glycine catalyzed by glycine amidinotransferase (GAT) in the kidney and the pancreas1. Previous studies have demonstrated a marked decrease in the amount of urinary GAA excretion in cases of uremia2–4


Interstitial Nephritis Acute Pyelonephritis Leucine Aminopeptidase Urinary Activity Guanidino Compound 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Shuei Nakayama
    • 1
  • Masahiro Junen
    • 1
  • Ikuo Kiyatake
    • 1
  • Hikaru Koide
    • 1
  1. 1.Division of Nephrology, Department of MedicineJuntendo University School of MedicineTokyoJapan

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