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Is Guanidine a Marker of Peroxidation in Uremics?

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Guanidines 2

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Abstract

There are many reports concerning the toxicity of oxygen in various disease states1–4 Recently, attention has been called to the unfavorable effects of active oxygen in renal diseases5–9. We have reported that the hydroxyl radical plays an important role in vitro10 and in isolated rat hepatocytes11 in the peroxidation of creatinine (CRN) to methylguanidine (MG), a guanidino compound known to be a potent uremic toxin. In this study, we investigate the correlation between some markers of the peroxidative state and the concentration of various guanidino compounds in the sera of patients undergoing regular hemodialysis.

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Author information

Authors and Affiliations

  1. Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, 305, Japan

    Sohji Nagase, Kazumasa Aoyagi, Masako Sakamoto, Mitsuhiro Miyazaki, Shoji Ohba, Mitsuharu Narita & Shizuo Tojo

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  1. Sohji Nagase
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  2. Kazumasa Aoyagi
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  3. Masako Sakamoto
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  4. Mitsuhiro Miyazaki
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  5. Shoji Ohba
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  6. Mitsuharu Narita
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  7. Shizuo Tojo
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Editor information

Editors and Affiliations

  1. Okayama University Medical School, Okayama, Japan

    Akitane Mori

  2. The Bronx Lebanon Hospital Center, Bronx, New York, USA

    Burton D. Cohen

  3. Juntendo University School of Medicine, Tokyo, Japan

    Hikaru Koide

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© 1989 Plenum Press, New York

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Nagase, S. et al. (1989). Is Guanidine a Marker of Peroxidation in Uremics?. In: Mori, A., Cohen, B.D., Koide, H. (eds) Guanidines 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0821-8_33

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  • DOI: https://doi.org/10.1007/978-1-4613-0821-8_33

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8099-6

  • Online ISBN: 978-1-4613-0821-8

  • eBook Packages: Springer Book Archive

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