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Guanidines 2 pp 135-136 | Cite as

Amelioration of Guanidinoacetic Acid Metabolism in Streptozotocin-Induced Diabetic Rats by Insulin Treatment

  • Masayoshi Hirata
  • Shuichi Hatakeyama
  • Katsuo Haruki
  • Hiroaki Muramoto
  • Yohei Tofuku
  • Ryoyu Takeda

Abstract

We have already reported1 that in diabetic patients serum guanidino- acefcic acid (GAA) is lower than in normal subjects in spite of the absence of renal dysfunction and the pancreatic glycine amidinotransferase (GAT) activity decreases in the experimental diabetic rats, although the effect of insulin on pancreatic GAT activity was yet under investigation. Funahashi et al.2 reported that in the perfusion experiments on isolated kidney, GAT activity was significantly diminished in diabetic rats, and was not restored to the control level by insulin administration. From this point of view, we measured serum concentration of GAA and the renal and pancreatic GAT activities in controls, streptozotocin (STZ)-induced diabetic, and insulin-treated diabetic rats.

Keywords

Insulin Treatment Insulin Administration Perfusion Experiment Measure Serum Concentration Guanidinoacetic Acid 
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References

  1. 1.
    Hirata, M., Muramoto, H., Haruki, K., Miyazaki, F., Tofuku, Y., Takeda, R., Impared metabolism of guanidinoacetic acid in uremia with special reference to diabetic nephropathy, in: “3rd Asian-Pacific Congress of Nephrology”, Singapore, in 1986.Google Scholar
  2. 2.
    Funahashi, M., Kato, H., Shiosaka, S., Nakagawa, H., Formation of arginine and guanidinoacetic acid in the kidney in vivo. Their relations with the liver and their regulation, J. Biochem. 89 (1981) 1347–1356.Google Scholar
  3. 3.
    Van Pilsum, J.F., Berman, D.A., Wol, E.A., Assay and some properties of kidney transamidinase, Proc. Soc. Exp. Biol. Med. 95 (1957) 96–100.Google Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Masayoshi Hirata
    • 1
  • Shuichi Hatakeyama
    • 1
  • Katsuo Haruki
    • 1
  • Hiroaki Muramoto
    • 1
  • Yohei Tofuku
    • 1
  • Ryoyu Takeda
    • 1
  1. 1.The 2nd Department of Internal MedicineSchool of Medicine Kanazawa UniversityKanazawa 920Japan

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