Amelioration of Guanidinoacetic Acid Metabolism in Streptozotocin-Induced Diabetic Rats by Insulin Treatment
We have already reported1 that in diabetic patients serum guanidino- acefcic acid (GAA) is lower than in normal subjects in spite of the absence of renal dysfunction and the pancreatic glycine amidinotransferase (GAT) activity decreases in the experimental diabetic rats, although the effect of insulin on pancreatic GAT activity was yet under investigation. Funahashi et al.2 reported that in the perfusion experiments on isolated kidney, GAT activity was significantly diminished in diabetic rats, and was not restored to the control level by insulin administration. From this point of view, we measured serum concentration of GAA and the renal and pancreatic GAT activities in controls, streptozotocin (STZ)-induced diabetic, and insulin-treated diabetic rats.
KeywordsInsulin Treatment Insulin Administration Perfusion Experiment Measure Serum Concentration Guanidinoacetic Acid
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