Guanidines 2 pp 97-105 | Cite as

The Reactivity of Guanidino Compounds with Hydroxyl Radicals

  • Midori Hiramatsu
  • Rei Edamatsu
  • Masahiro Kohno
  • Akitane Mori


Guanidinoethanesulfonic acid1, guanidinoacetic acid (GAA)2, N-acetyl-arginine (NAA)3, γ-guanidinobutyric acid (GBA)4, methylguanidine (MGua)5, α-guanidinoglutaric acid6 and homoarginine7, which are detected in the mammalian brain, induce epileptic discharges and/or induce convulsions after intracisternal injection or local administration into the rodent cortex. The seizure mechanisms are still unclear.


Electron Spin Resonance Electron Spin Resonance Spectrometer Spin Adduct Hydroxyl Radical Generation Epileptic Discharge 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Midori Hiramatsu
    • 1
  • Rei Edamatsu
    • 1
  • Masahiro Kohno
    • 2
  • Akitane Mori
    • 1
  1. 1.Department of NeurochemistryInstitute for Neurobiology Okayama University Medical SchoolOkayamaJapan
  2. 2.JE0L Ltd.TokyoJapan

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