Guanidines 2 pp 97-105 | Cite as

The Reactivity of Guanidino Compounds with Hydroxyl Radicals

  • Midori Hiramatsu
  • Rei Edamatsu
  • Masahiro Kohno
  • Akitane Mori

Abstract

Guanidinoethanesulfonic acid1, guanidinoacetic acid (GAA)2, N-acetyl-arginine (NAA)3, γ-guanidinobutyric acid (GBA)4, methylguanidine (MGua)5, α-guanidinoglutaric acid6 and homoarginine7, which are detected in the mammalian brain, induce epileptic discharges and/or induce convulsions after intracisternal injection or local administration into the rodent cortex. The seizure mechanisms are still unclear.

Keywords

Superoxide Arginine Dimethyl Sodium Hydroxide Half Life 

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Midori Hiramatsu
    • 1
  • Rei Edamatsu
    • 1
  • Masahiro Kohno
    • 2
  • Akitane Mori
    • 1
  1. 1.Department of NeurochemistryInstitute for Neurobiology Okayama University Medical SchoolOkayamaJapan
  2. 2.JE0L Ltd.TokyoJapan

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