Molecular and Physiological Properties of Plasma Membranes: The Role of Ion Channels

  • M. Cereijido
  • M. S. Balda
  • A. Ponce
  • J. J. Bolivar

Abstract

At the beginning of this century, once biologists convinced themselves that cells must be surrounded by a lipidic membrane, it became necessary to assume that this membrane has mechanisms to translocate ions and molecules which are not soluble in lipids. Among the first mechanisms proposed were water filled pores (see Cereijido and Rotunno, 1970). Years later, research with tracer fluxes and impaling (“classical”) microelectrodes supported the concept that the cell membrane is perforated with a variety of water channels that are permeable to specific ionic species, may be opened and closed by gates which are sometimes sensitive to the electrical potential differences between the two sides of the membrane, and that may be influenced by signal molecules bound to nearby receptors.

Keywords

Migraine Mane Acetylcholine Verapamil Diphenylhydantoin 

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • M. Cereijido
    • 1
  • M. S. Balda
    • 1
  • A. Ponce
    • 1
  • J. J. Bolivar
    • 1
  1. 1.Center of Research and Advanced StudiesMéxico 14, D.F.México

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