Molecular Basis of Contrast in MRI

  • T. F. Egan
  • H. E. Rorschach
  • C. F. Hazlewood


Water is an essential component as well as the most abundant molecule in all living systems. In magnetic resonance imaging (MRI) water is fundamental to image formation. Furthermore, the physical-chemical properties of cellular and extracellular water provide major contributions to the inherent contrast found in each image. The physical properties of water as a solvent are subject to change when macromolecular structure and/or motion is altered. Thus, precise knowledge of water-macromolecular interactions is required for our understanding of information content in an image obtained by magnetic resonance techniques.


Relaxation Rate Correlation Time Water Proton Larmor Frequency Nuclear Magnetic Resonance Relaxation 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • T. F. Egan
    • 1
  • H. E. Rorschach
    • 2
  • C. F. Hazlewood
    • 1
  1. 1.Department of Physiology and Molecular BiophysicsBaylor College of MedicineHoustonUSA
  2. 2.Physics DepartmentRice UniversityHoustonUSA

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