Abstract
Diarrhea constitutes the single most important cause of death in infants and children born in developing areas of the world (Puffer and Serrano, 1973). The widespread use of oral rehydration in recent years has lead to a decrease in the mortality rate due to this disease. Treatment albeit does not prevent moderate to severe malnutrition, the main complication of acute infectious diarrhea. The long term effects of this dyad on the physical growth and mental development of affected individuals have been well documented (Cravioto and Arrieta, 1986). For these reasons, the aim of several research groups during the past ten years has been the development of specific vaccines to be used in prevention programs against diarrhea. This approach has been specially apparent in relation with cholera and typhoid fever, where parental vaccines developed earlier have been substituted by oral presentations prepared with dead organisms, live attenuated strains or combinations of both (Levine and Tramont, 1986; Levine et al., 1987).
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References
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© 1988 Plenum Press, New York
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Cravioto, A., Reyes, R.E., Trujillo, F., Tello, A., Vázquez, V. (1988). Oral Vaccination of Human Volunteers WithgalE Mutants of Enteropathogenic Escherichia coli. In: Cañedo, L.E., Todd, L.E., Packer, L., Jaz, J. (eds) Cell Function and Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0813-3_24
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DOI: https://doi.org/10.1007/978-1-4613-0813-3_24
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