Protein Kinase C: Structure, Function And Modulation Of Its Catalytic Activity By Physiological And Pharmacological Agents

  • Charles W. Mahoney
  • Angelo Azzi

Abstract

Extracellular agonist-cell surface receptor cell activation pathways can be mediated through the second messengers diacylglycerol and inositol-triphosphate which in turn can activate PKC kinase activity directly in the former case and indirectly in the latter by release of internally stored calcium. The initial steps of physiological cell activation processes are often of a transient nature and hence there have to be mechanisms for turning off the activation process. Several mechanisms of deactivation have been elucidated such as the metabolism of DAG to either phosphatidic acid (re-generation of phosphatidylinositol path) or further catabolism to monoacyl-glycerol and glycerol thereby generating fatty acids such as arachidonic acid, which can be further metabolized to a series of potent biological effectors, the prostaglandins. Inositol-1,4,5-triphosphate (IP3) is also normally a transient message being further phosphorylated to IP4 and IP5 and IP6 or being dephosphorylated to IP2, IP1, and inositol (regeneration of phosphatidylinositol path) (for reviews see Nishizuka, 1984, 1986; Berridge, 1987).

Keywords

Superoxide Serine Prostaglandin Neuroblastoma Amphotericin 

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References

  1. Baehner, R. L., Boxer, L. A., Ingraham, L. M., Butterick, C., and Haak, R. A., 1982, Ann. N.Y. Acad. Sei.. 393: 235.CrossRefGoogle Scholar
  2. Baines, D.M., 1986, Science. 233: 419.Google Scholar
  3. Berridge, M.J., 1987, Ann. Rev. Biochem.. 56: 159.PubMedCrossRefGoogle Scholar
  4. Brockerhoff, H., 1986, FEBS Lett.. 201: 1.PubMedCrossRefGoogle Scholar
  5. Cantley, L.C., Cantley, L.G., and Jospephson, L., 1978, J. Biol. Chem.. 253: 7361.PubMedGoogle Scholar
  6. Castagna, M., Takai, Y., Kaibuchi, K., Sano, K., Kikkawa, U., and Nishizuka, Y., 1982, J. Biol. Chem.. 257: 7847.PubMedGoogle Scholar
  7. Collins, J.M., Klecker, R.W., Yarchoan, R., Lane, H.C., Fauci, A.S., Redfield, R.R., Broder, S., and Meyers, C.E., 1986, J. Clin. Pharmacol.. 26: 22.PubMedGoogle Scholar
  8. Coussens, L., Parker, P.J., Rhee, L., Yang-Feng, T.L., Chen, E., Waterfield, M.D., Francke, U., and Ullrich, A., 1986, Science. 233: 859.PubMedCrossRefGoogle Scholar
  9. Danpure, C.J., Fyfe, D.A., and Gumpel, J.M., 1979, Ann. Rheum. Pis.. 38: 364.CrossRefGoogle Scholar
  10. Davis, R.J., Ganong, B.R., Bell, R.M., and Czech, M.P., 1985, J. Biol. Chem.. 260: 1358.Google Scholar
  11. De Clercq, E., 1987, Antiviral Res.. 7: 1.PubMedCrossRefGoogle Scholar
  12. Duggan, D.E., 1959, Arch. Biochem. Biophys.. 84: 116.PubMedCrossRefGoogle Scholar
  13. Erdmann, E., Werdman, K., Krawietz, W., Schmitz, W., and Scholz, H., 1984, Biochem. Pharmacol.. 33: 945.PubMedCrossRefGoogle Scholar
  14. Froscio, M., Solanki, U., Murray, A.N., and Hurst, N.P., 1988, Biochem. Pharmacol.. 37: 366.PubMedCrossRefGoogle Scholar
  15. Gerber, R.C., Paulus, H.E., Bluestone, R., and Lederer, M., 1972, Arth. Rheum.. 15: 622.CrossRefGoogle Scholar
  16. Go, M., Sekiguchi, K., Nomura, H., Kikkawa, U., and Nishizuka, Y., 1987, Biochem. Biophys. Res. Commun.. 144: 598.PubMedCrossRefGoogle Scholar
  17. Goodno, C.C., 1982, Methods Enzymol.. 85: 116.PubMedCrossRefGoogle Scholar
  18. Hafstrom, I., Seligman, B.E., Friedman, M.M., and Gallin, J.I., 1984, J. Immunol.. 132: 2007.PubMedGoogle Scholar
  19. Helson, L., Verma, M., and Helson, C., 1982, Ann. N.Y. Acad. Sei., 393: 226.CrossRefGoogle Scholar
  20. Heyliger, C.E., Tahiliani, A.G., and McNeill, J.H., 1985, Science. 227: 1474.PubMedCrossRefGoogle Scholar
  21. Hidaka, H., Inagaki, M., Kawamoto, S., and Sasaki, Y., 1984, Biochemistry. 23: 5036.PubMedCrossRefGoogle Scholar
  22. House, C., and Kemp, B.E., 1987, Science. 238: 1726.PubMedCrossRefGoogle Scholar
  23. Isler, O., and Brubacher, G., 1982, in: “Vitamine”, Vol. 1, Georg Thieme Verlag, NY. p. 126.Google Scholar
  24. Jeffrey, A.M., and Liskamp, M.J., 1986, Proc. Natl. Acad. Sei. USA, 83: 241.CrossRefGoogle Scholar
  25. Josephson, L., and Cantley, L.C., 1977, Biochemistry. 16: 4572.PubMedCrossRefGoogle Scholar
  26. Kase, H., Iwahashi, K., Nakanishi, S., Matsuda, Y., Yamada, K. Takahshi, M., Murakata, C., Sato, A., and Kaneko, M., 1987, Biochem. Biophys. Res. Commun.. 142: 436.PubMedCrossRefGoogle Scholar
  27. Kase, H., Iwahashi, K., and Matsuda, Y., 1986, J. Antibiotics, 39: 1059.Google Scholar
  28. Kawahara, Y., Takai, Y., Minakuchi, R., Sano, K., and Nishizuka, Y., 1980, Biochem. Biophys. Res. Commun.. 97: 309.PubMedCrossRefGoogle Scholar
  29. Kikkawa, U., Ogita, K., Ono,Y., Asaoka, Y., Shearman, M.S., Fujii, T., Ase,K., Sekiguchi, K., Igarashi, K., and Nishizuka, Y., 1987, FEBS Lett.. 223: 212.PubMedCrossRefGoogle Scholar
  30. Kishimoto, A., Takai, Y., Mori, T., Kikkawa, U., and Nishizuka Y., 1980,, J. Biol. Chem.. 255: 2273.PubMedGoogle Scholar
  31. Knopf, J.L., Lee, M., Sultzman, L.A., Kriz, R.W., Loomis, C.R. Hewick, R.M., and Bell, R.M., 1986, Cell. 46:491.PubMedCrossRefGoogle Scholar
  32. Kondo, H., Baba, Y., Takai, K., Kondo, K. and Kagamiyama, H., 1987, Biochem. Biophys. Res. Commun.. 142: 155.PubMedCrossRefGoogle Scholar
  33. Kuo, J.F., Schatzman, R.C., Turner, R.S., and Mazzei, G.J., 1984, Mol, and Cell. Endocrinol.. 35: 65.CrossRefGoogle Scholar
  34. Lapetina, E.G., Reep, B., Ganong, B.R., and Bell, R.M., 1985, J. Biol. Chem.. 260: 1358.PubMedGoogle Scholar
  35. Liu, A.Y., and Chen K.Y., 1985, J. Cell Physiol.. 125: 387.PubMedCrossRefGoogle Scholar
  36. Lubin, B., and Machlin, L.J., 1982, Ann. N.Y. Acad. Sei.. 393: 1.CrossRefGoogle Scholar
  37. Mahoney, C.W., and Azzi, A., 1988, Experientia. 44:A82.CrossRefGoogle Scholar
  38. Mahoney, C.W., and Azzi, A., a) in: “Dynamics of Membrane Proteins and Cellular Energetics”, N. Latruffe, Y. Gaudemer, P. Vignais, A. Azzi, eds., Springer Verlag, Berlin, in press.Google Scholar
  39. Mahoney, C.W., and Azzi, A., b) in: “Perspectives in Molecular Approaches to Human Disease”, S. Papa, J. Tager, J. Jaz, eds., Ellis Horwood, London, in press.Google Scholar
  40. Mahoney, C.W., and Azzi, A., in press, c) Biochem. Biophys. Res. Commun.Google Scholar
  41. Mahoney, C.W., Fredenhagen A., Peter, H., and Azzi, A., Biological Chem. Hoppe-Seyler, in press.Google Scholar
  42. Mahoney, C.W., Fredenhagen, A., Peter, H., and Azzi, A., (submitted).Google Scholar
  43. Naka, M., Nishikawa, M., Adelstein, R.S., and Hidaka, H., 1983 Nature. 306: 490.PubMedCrossRefGoogle Scholar
  44. Nakanishi, S., Matsuda, Y., Iwahashi, K., and Kase, H., 1986, J. Antibiotics. 39: 1066.Google Scholar
  45. Nishizuka, Y., 1984, Nature. 308: 693.PubMedCrossRefGoogle Scholar
  46. Nishizuka, Y., 1986, Science. 233: 305.PubMedCrossRefGoogle Scholar
  47. Nour-Eldeen, A.F., Craig, M.M., and Gresser, M.J., 1985, J. Biol. Chem.. 260: 6836.PubMedGoogle Scholar
  48. Ohno, S., Kawasaki, H., Imajoh, T., Suzuki, K., Inagaki, M., Yokokura, H., Sakoh, T., and Hidaka, H., 1987, Nature. 325: 161.PubMedCrossRefGoogle Scholar
  49. Ossikovski, E., and Walter, R.D., 1984, Mol, and Biochem. Parasitol.. 12: 299.CrossRefGoogle Scholar
  50. Parente, J.E., Wong, K., and Davis, P., 1986, Inflammation. 10: 303.PubMedCrossRefGoogle Scholar
  51. Parker, P.J., Coussens, L., Totty, N., Rhee, L., Young, S., Chen, E., Stabel, S., Waterfield, M.D., and Ullrich, A., 1986, Science. 33: 853.CrossRefGoogle Scholar
  52. Pope, M.T., and Dale, B.W., 1968, Quart. Rev. Chem. Soc.. 22: 527.CrossRefGoogle Scholar
  53. Ramasarma, T., and Crane, F.L., 1981, Curr. Cont. Cell. Requl. 20: 247.Google Scholar
  54. Ruusala, A.I., Mattsson, M., Esscher, T., Abrahamsson, L., Jergil, B., and Pahlman, S., 1985, Develop. Brain Res., 18: 27.CrossRefGoogle Scholar
  55. Sadler, P.J., 1976, Struct. Bonding. 29: 171.CrossRefGoogle Scholar
  56. Sano, K., Takai, Y., Yamanashi, J., and Nishizuka, Y., 1983, J Biol. Chem., 258: 2010.PubMedGoogle Scholar
  57. Sharkey, N.A., Leach, K.L., and Blumberg, P.M., 1984, Proc. Natl. Acad. Sei.. USA. 81: 607.CrossRefGoogle Scholar
  58. Shaw, C.F., 1979, Inorq. Persp. in Biol, and Med.. 2: 287.Google Scholar
  59. Simons, T.J.B., 1979, Nature. 281: 337.PubMedCrossRefGoogle Scholar
  60. Slater, E.C., 1960, in: “4th International Congress of Biochem.”, Vienna; Pergamon, London, p. 316.Google Scholar
  61. Solomon, D.M., O’Brian, C.A., and Weinstein, I.B., 1985, FEBS Lett.. 190: 342.PubMedCrossRefGoogle Scholar
  62. Steiner, M., and Mower, R., 1982, Ann. N.Y. Acad. Sei.. 393: 289.CrossRefGoogle Scholar
  63. Stuart, M.J., 1982, Ann. N.Y. Acad. Sei.. 393: 277.CrossRefGoogle Scholar
  64. Takai, Y., Kishimoto, A., Kikkawa, U., Mori, T., and Nishizuka Y., 1979, Biochem. Biophvs. Res. Commun.. 91: 1218.CrossRefGoogle Scholar
  65. Tamaoki, T., Takahashi, I., Kato, Y., Morimoto, M., and Tomita F., 1986, Biochem. Biophys. Res. Commun.. 135: 397.PubMedCrossRefGoogle Scholar
  66. Tamura, S., Brown, T.A., Whipple, J.H., Fujita-Yamaguchi, Y., Dubler, R.E., Cheng, K., and Larner, J., 1984, J. Biol. Chem.. 259:6650.Google Scholar
  67. Tracey, A.S., and Gresser, M.J., 1986, Proc. Natl. Acad. Sei.. USA. 83: 609.CrossRefGoogle Scholar
  68. Walter, R.D., 1980, Mol. and Biochem. Parasitol.. 1: 139.CrossRefGoogle Scholar
  69. Wasserman, R.H., and Taylor, A.N., 1972, Ann. Rev. Biochem.. 41: 182.CrossRefGoogle Scholar
  70. Watson, S.P., McNally, J., Shipman, L.J., and Godfrey P.P., 1988, Biochem. J.. 249: 345.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Charles W. Mahoney
    • 1
  • Angelo Azzi
    • 1
  1. 1.Institut für Biochemie und MolekularbiologieUniversität BernBernSwitzerland

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