Abstract
While the major features of the intracellular route traveled by the hemagglutinin (HA) and neuraminidase (NA) glycoproteins of influenza virus were established more than a decade ago by a synthesis of studies of virus morphogenesis with investigations of the secretory pathway in mammalian cells, our understanding of the biosynthesis of these viral envelope glycoproteins has expanded dramatically during the past 5 years. This progress has depended in part on the availability of detailed information on the structure of the HA and NA glycoproteins, and on the ability to express cloned genes encoding these polypeptides. These advances rest on a foundation of more than half a century of investigation of the nature of the surface antigens of a virus that remains one of the uncontrolled pathogens of man.
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References
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Roth, M.G., Gething, MJ., Sambrook, J. (1989). Membrane Insertion and Intracellular Transport of Influenza Virus Glycoproteins. In: Krug, R.M. (eds) The Influenza Viruses. The Viruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0811-9_5
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