Clinical Pharmacokinetic Considerations in Gastroenterology

  • Varocha Mahachai
Part of the Topics in Gastroenterology book series (TGEN)


Physiological changes in gastrointestinal and liver disease alter drug pharmacokinetics, although the alterations are of poorly defined clinical significance. Quite often these changes are unpredictable, depending on the nature of the drug and the clinical status of the patient. In the presence of liver disease, the dosage of a drug metabolized by the liver is often adjusted empirically. Specific guidelines are lacking because the available clinical and biochemical assessments of liver disease are inadequate. Even less is known about the effect of gastrointestinal disease on drug handling. Impaired drug absorption may become critical when a rapid onset of drug action is required or when elimination is so rapid that effective plasma concentrations cannot be maintained. Therefore, the adjustment of dosage and route of administration for some drugs may be necessary to attain optimal pharmacological effect.


Liver Disease Drug Absorption Celiac Disease Gastric Emptying Hepatic Blood Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • Varocha Mahachai
    • 1
  1. 1.Division of Gastroenterology, Department of MedicineUniversity of AlbertaEdmontonCanada

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