Pathophysiology of Diarrhea

Mechanisms of Action of Antidiarrheal Agents
  • N. W. Read
Part of the Topics in Gastroenterology book series (TGEN)


It has been estimated that approximately 9 liters of fluid enters the gut each day: 1–1.5 liters from the diet; the rest as digestive secretions from the liver, pancreas, stomach, and small intestine. The majority of this fluid is absorbed during fairly rapid passage through the small intestine. About 1–1.5 liters passes through the ileocecal valve into the colon, and 90% of this is absorbed in the colon leaving the subject to pass a solid stool of approximately 100 g.


Bile Acid Irritable Bowel Syndrome Cholera Toxin Vasoactive Intestinal Polypeptide Intestinal Secretion 
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Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • N. W. Read
    • 1
  1. 1.Sub-Department of Human Gastrointestinal Physiology and NutritionRoyal Hal-lamshire HospitalSheffieldUK

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