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Celiac Disease

Pathogenesis and Clinical Features

  • Chapter
Modern Concepts in Gastroenterology Volume 2

Part of the book series: Topics in Gastroenterology ((TGEN))

Abstract

Celiac disease (gluten-sensitive enteropathy, celiac sprue, or nontropical sprue) is characterized by damage to the small intestine mucosa and the malabsorption of most nutrients. Symptoms most commonly appear during the first 3 years of life after the introduction of cereals into the diet, with a second peak incidence occurring during the third decade.1 Clinical manifestations predominantly reflect the consequences of malabsorption. Although celiac disease was noted in earlier centuries,2,3 a striking decrease in the incidence of celiac disease was observed in Holland during the wheat-deprived years of World War II; this suggested an association between celiac disease and the ingestion of wheat-containing products.4,5

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Authors and Affiliations

  1. Laboratory of Mucosal Immunology, Department of Medicine, University of California-San Diego, La Jolla, California, 92093, USA

    Martin F. Kagnoff

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  1. Martin F. Kagnoff
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  1. University of Calgary, Calgary, Alberta, Canada

    Eldon Shaffer M.D.

  2. The University of Alberta, Edmonton, Alberta, Canada

    Alan B. R. Thomson M.D., Ph.D.

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Kagnoff, M.F. (1989). Celiac Disease. In: Shaffer, E., Thomson, A.B.R. (eds) Modern Concepts in Gastroenterology Volume 2. Topics in Gastroenterology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0781-5_13

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