Celiac Disease

Pathogenesis and Clinical Features
  • Martin F. Kagnoff
Part of the Topics in Gastroenterology book series (TGEN)


Celiac disease (gluten-sensitive enteropathy, celiac sprue, or nontropical sprue) is characterized by damage to the small intestine mucosa and the malabsorption of most nutrients. Symptoms most commonly appear during the first 3 years of life after the introduction of cereals into the diet, with a second peak incidence occurring during the third decade.1 Clinical manifestations predominantly reflect the consequences of malabsorption. Although celiac disease was noted in earlier centuries,2,3 a striking decrease in the incidence of celiac disease was observed in Holland during the wheat-deprived years of World War II; this suggested an association between celiac disease and the ingestion of wheat-containing products.4,5


Celiac Disease Coeliac Disease Celiac Disease Patient Dermatitis Herpetiformis Celiac Sprue 
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Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • Martin F. Kagnoff
    • 1
  1. 1.Laboratory of Mucosal Immunology, Department of MedicineUniversity of California-San DiegoLa JollaUSA

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