Altered Carbohydrate Antigen Expression In Colorectal Cancer And Polyps
Cancer of the colon and rectum is the most common gastrointestinal malignancy in many Western countries. In the United States, it is estimated that in 1989 there will be 150,000 new cases of colorectal cancer diagnosed and that 65,000 deaths from colorectal cancer will occur. The overall 5-year survival rate for patients with colorectal cancer is only 40–45%, a figure that has changed very little over the last two decades.1 Disease prevention appears to provide the best hope for improving the outcome of individuals with colorectal cancer. There are two approaches to disease prevention: Primary prevention involves identifying and eliminating the cause of the disease and also includes careful monitoring of populations at high risk for developing the disease. In the case of colorectal cancer, various environmental and host factors have been suggested to play a role in carcinogenesis, but the actual causative agents are not yet known. Recently, some progress has been made in identifying subjects at high risk for developing colorectal cancers among family members of familial polyposis coli or colon cancer family syndromes. The approach has been to investigate the biochemical or cell proliferative activities in normal appearing colonic mucosa (i.e., “flat mucosa”) in an effort to identify the genotype carrier state and to monitor the progression to severe dysplasia in affected patients.2–5
KeywordsSialic Acid Blood Group Distal Colon Adenomatous Polyp Hyperplastic Polyp
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