Skip to main content

Integration of Neural Inputs in Peripheral Airway Ganglia

  • Chapter
Airway Smooth Muscle in Health and Disease

Abstract

The goal of this chapter is to review information related to neural control of airway smooth muscle, and integration of neural inputs to airway smooth muscle. Neural inputs to airway smooth muscle can be controlled and modulated at the level of the central nervous system (CNS), the peripheral airway ganglia, and at the neuromuscular junction. Mechanisms of integration of neural inputs at the level of the peripheral airway parasympathetic ganglia and at the neuromuscular junction are discussed. Control and modulation at the level of the CNS are not discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Akasu, T., Hirai, K., and Koketsu, K., 1981a, 5-Hydroxytryptamine controls ACh-receptor sensitivity of bullfrog sympathetic ganglion cells, Brain Res. 212: 217–220.

    Article  Google Scholar 

  • Akasu, T., Hirai, K., and Koketsu, K., 1981b, Increase of acetylcholine-receptor sensitivity by adnosine triphosphate: A novel action of ATP on ACh-sensitivity, Br. J. Pharmacol. 74:505–507.

    PubMed  CAS  Google Scholar 

  • Altier, R. J., and Diamond, L., 1985, Effect of alpha chymotrypsin on the non-adrenergic, non-cholinergic inhibitory system in cat airways, Eur. J. Pharmacol. 114:75–78.

    Article  Google Scholar 

  • Altier, R. J., and Diamond, L., 1986, Role of vagal sensory fibers in nonadrenergicnoncholinergic inhibitory responses in cat airways, Am. Rev. Respir. Dis. 133:1159–1162.

    Google Scholar 

  • Altier, R. J., Szarek, J. L., and Diamond, L., 1984, Neural control of relaxations in cat airway smooth muscle, J. Appl. Physiol. . 57:1536–1548.

    Google Scholar 

  • Andersson, R. G., and Grundstrom, N., 1983, The excitatory non-cholinergic non-adrenergic nervous system of the guinea-pig airways, Eur. J. Respir. Dis. 131(Suppl.):141–157.

    CAS  Google Scholar 

  • Ashe, J. H., and Libit, B., 1981, Modulation of slow postsynaptic potentials by dopamine in rabbit sympathetic ganglion, Brain Res. 217:93–106.

    Article  PubMed  CAS  Google Scholar 

  • Baker, D. G., Basbaum, C. B., Herbert, D. A., and Mitchell, R. A., 1983, Transmission in airway ganglia of ferrets: Inhibition by norepinephrine, Neurosci. Lett. 41:139–143.

    Article  PubMed  CAS  Google Scholar 

  • Baker, D. G., McDonald, D. M., Basbaum, C. B., and Mitchell, R. A., 1986, The architecture of nerves and ganglia of the ferret trachea as revealed by acetylcholinesterasehistochemistry, J. Comp. Neurol. 246:513–526.

    Article  PubMed  CAS  Google Scholar 

  • Baluk, P., Fumiwara, T., and Martsuda, S., 1985, The fine structure of the ganglia of the guinea pig trachea, Cell Tissue Res. 239:51–60.

    Article  PubMed  CAS  Google Scholar 

  • Blackman, J. G., Crawcroft, P. J., Devine, C. E., Holman, M. E., and Yonemura, K., 1969, Transmission from preganglionic fibres in the hypogastric nerve to peripheral ganglia of male guinea pigs, J. Physiol. (Lond.) 201:723–743.

    PubMed  CAS  Google Scholar 

  • Bloomquist, E. I., and Kream, R. M., 1988, Leukotriene D4 acts in part to control guinea pig ileum smooth muscle by releasing substance P, J. Pharmacol. Exp. Ther. 240:523–528.

    Google Scholar 

  • Boyle, J. P., Davies, J. M., Foster, R. W., Morgan, G. W., and Small, R. C, 1987, Inhibitoryresponses to nicotine and transmural stimulation in hyoscine-treated guinea-pig isolated trachealis muscle, Br. J. Pharmacol. 90:733–744

    PubMed  CAS  Google Scholar 

  • Cabezas, G. A., Graf, P. D., and Nadel, J., 1971, Sympathetic versus parasympathetic nervousregulation of airways in dogs, J. Appl. Physiol. 31:651–665.

    PubMed  CAS  Google Scholar 

  • Cameron, A. R., and Coburn, R. F., 1981, Electrical properties of the cells of the ferret paratrachealganglion, Physiologist 24:84.

    Google Scholar 

  • Cameron, A. R., and Coburn, R. F., 1984, Electrical and anatomic characteristics of cells of theferret paratracheal ganglion, Am. J. Physiol. 246:C450–458

    PubMed  CAS  Google Scholar 

  • Cameron, A. R., and Kirkpatrick, C. T., 1977, A study of excitatory neuromuscular transmission inthe bovine trachea, J. Physiol. (Lond.) 270:733–745.

    CAS  Google Scholar 

  • Cameron, A. R., Bullock, C. G., and Kirkpatrick, C. T. 1982, The ultrastructure of bovine trachealsmooth muscle, J. Ultrastruct. Res. 81:290–305.

    Article  PubMed  CAS  Google Scholar 

  • Cameron, A. R., Johnston, C. F., Kirkpatrick, C. T., and Kirkpatrick, M. C. A., 1983, The questfor the inhibitory neurotransmitter in bovine tracheal smooth muscle, Q. J. Exp. Physiol. 68:413–426.

    PubMed  CAS  Google Scholar 

  • Chiang, C. H., and Gabella, G., 1986, Quantitative study of the ganglion neurons of the mousetrachea, Cell Tissue 100:243–252.

    Article  Google Scholar 

  • Chesrown, S. E., Venugopalan, C. S., Gold, W. M., and Drazen, J. M., 1980, In vivo demonstration of nonadrenergic inhibitory innervation of the guinea pig trachea, J. Clin. Invest. 654:315–320.

    Google Scholar 

  • Christ, D. D., and Nishi, S., 1969, Presynaptic action of epinephrine on sympathetic ganglia, Life Sci. 8:1235–1238

    Article  PubMed  CAS  Google Scholar 

  • Chung, K. F., Evans, T. W., Graf, P. D., and Nadel, J. A., 1985, Modulation of cholinergicneurotransmission in canine trachealis muscle by thromboxane mimetic U46619, Br. J. Pharmacol. 117:373–375.

    CAS  Google Scholar 

  • Coburn, R. F., 1984a, Neural coordination of excitation of ferret trachealis muscle, Am. J. Physiol. 246:C459–466.

    PubMed  CAS  Google Scholar 

  • Coburn, R. F., 1984b, The anatomy of the ferret paratracheal parasympathetic nerve-ganglionplexus, Exp. Lung Res. 7:1–9.

    Article  PubMed  CAS  Google Scholar 

  • Coburn, R. F., 1987, Colinergicneuroeffector mechanisms in airway smooth muscle, in: TheAirways, Neural Control in Health and Disease, Vol. 33: Lung Biology in Health and Disease,M. A. Kaliner and P. T. Barnes, eds.), pp. 159–186, Marcel Dekker, New York.

    Google Scholar 

  • Coburn, R. F., and Kalia, M. P., 1986, Morphological features of spiking and nonspiking cells in theparatracheal ganglion of the ferret, J. Comp. Neurol. 254:341–351.

    Article  PubMed  CAS  Google Scholar 

  • Coburn, R. F., and Tomita, T., 1973, Evidence for nonadrenergic inhibitory nerves in the guinea pigtrachealis muscle, Am. J. Physiol. 224:1072–1080.

    PubMed  CAS  Google Scholar 

  • Coburn, R. F., 1987, Effect of norepinephrine on neurotransmission in the AH cell of the ferretparatracheal ganglion, Fed. Proc. 46:704.

    Google Scholar 

  • Coleman, R. A., and Levy, G. P., 1974, A non-adrenergic inhibitory nervous pathway in the guineapig trachea, Br. J. Pharmacol. 52:167–174.

    PubMed  CAS  Google Scholar 

  • Dahlstrom, A., Fuxe, K., Hokfelt, T., and Norberg, K. A., 1966, Adrenergic innervation of thebronchial muscle of the cat, Acta Physiol. Scand. 66:507–508.

    Article  PubMed  CAS  Google Scholar 

  • DeGroat, W. C, and Booth, A. M., 1980, Inhibition and facilitation in parasympathetic ganglia ofthe urinary bladder, Fed. Proc. 39:2990–2996.

    CAS  Google Scholar 

  • DeGroat, W. C, and Saum, W. A., 1971, Adrenergic inhibition in mammalian parasympatheticganglia, Nature New Biol. 231:188–189.

    Article  CAS  Google Scholar 

  • Dey, R. D., Shannon, J.W.A., and Said, S. A., 1981, Localization of VIP immunoreactive nerves inairway and pulmonary vessels of dogs, cats and human subjects, Cell Tissue Res. 222:231–239.

    Google Scholar 

  • Diamond, L., and O’Donnell, M., 1980, A nonadrenergic vagal inhibitory pathway in feline airways, Science 208:185–188.

    Article  PubMed  CAS  Google Scholar 

  • Eranko, O., and Harkonen, M., 1963, Histochemical demonstration of fluorgenic amines in thecytoplasm of sympathetic ganglion cells of the rat, Acta Physiol. 58:285–286.

    Article  CAS  Google Scholar 

  • Fowler, J. C, and Weinreich, D., 1986, Electrophysiological membrane properties of paratrachealganglion neurons of the rabbit, Neurosci.Abstr. 11:1182.

    Google Scholar 

  • Fryer, A. D., and Maclagan, J., 1984, Muscarinic inhibitory receptors in pulmonary parasympatheticnerves in the guinea pig, Br. J. Pharmacol. 83:973–978.

    PubMed  CAS  Google Scholar 

  • Gaban, M., and Adams, P. R., 1982, Control of calcium current in rat sympathetic neurons bynorepinephrine, Brain Res. 244:155–144.

    Article  Google Scholar 

  • Gallagher, J. P., Griffith, W. J., III, and Shinnick-Gallagher, P., 1982, Cholinergic transmission incat parasympathetic neurons, J. Physiol. (Lond.) 332:473–486.

    CAS  Google Scholar 

  • Goyal, R. K., Rattan, S., and Said, S. I., 1980, VIP as a possible neurotransmitter of noncholinergic, non-adrenergic inhibitory neurones, Nature (Lond.) 288:378–380.

    Article  CAS  Google Scholar 

  • Greene, J. H., and Coburn, R. F., 1988, VIP and the inhibitory neurotransmitter in the guinea pigtrachealis muscle (submitted)

    Google Scholar 

  • Griffith, W. H. III, Gallagher, J. P., and Shinnick-Gallagher, P., 1981a, Sucrose-gap recordings ofnerve-evoked potentials in mammalian parasympathetic ganglia, Brain Res. 209:446–451.

    Article  PubMed  Google Scholar 

  • Griffith, W. H. III, Gallagher, J. P., and Shinnick-Gallagher, P., 1981b, Mammalian parasympathetic ganglia fire spontaneous action potentials and transmit slow potentials, in: Advances inPhysiological Sciences Vol 4. Physiology of Excitable Membranes (J. Salanki, ed.), pp. 347–350, AdademialKiado, Budapest.

    Google Scholar 

  • Inoue, T., and Ito, Y., 1985, Pre- and post-junctional effects of prostaglandin I2 and leukotriene C4in dog tracheal tissue. Br. J. Pharmacol. 84:289–298.

    PubMed  CAS  Google Scholar 

  • Inoue, T., Ito, Y., and Takeda, K., 1984, Prostaglandin induced inhibition of acetylcholine releasefrom neuronal elements of dog tracheal tissue, J. Physiol. (Lond.) 349:553–570.

    CAS  Google Scholar 

  • Jacobowitz, D., Kent, K. M., Fleisch, J. H., and Cooper, T., 1973, Histofluorescent study ofcatecholamine-containing elements in cholinergic ganglion from the calf and dog lung, Proc.Soc. Exp. Biol. Med. 144:464–466.

    PubMed  CAS  Google Scholar 

  • Karczmar, A. G., Koketsu, K., and Nishi, S., 1986, Autonomic and Enteric Ganglia, Plenum, NewYork.

    Google Scholar 

  • Kawatani, M., Rutigliano, M., and DeGroat, W. C, 1986, Selective facilitatory effects of vasoactive intestinal polypeptide on muscarinic mechanisms in sympathetic and parasympatheticganglia of the cat, in: Dynamics of Cholinergic Function, (I. Hanin, ed.), Plenum, NewYork.

    Google Scholar 

  • Knight, D. S., 1980, A light and electron microscopic study of feline intrapulmonary ganglia, J.Anat. (Lond.) 131:413–428.

    CAS  Google Scholar 

  • Knight, D. S., Hyman, A. L., and Kadowitz, P. J., 1981, Innervation of intrapulmonary airwaysmooth muscle of the dog, monkey and baboon, J. Auton. Nerv. Syst. 3:31–43.

    Article  PubMed  CAS  Google Scholar 

  • Koketsu, K., 1981, Electropharmacological actions of catecholamine in sympathetic ganglia: Multiple modes of actions to modulate the nicotinic transmission, Jpn. J. Pharmacol. 31(Suppl.):27P–28P.

    PubMed  Google Scholar 

  • Koketsu, K., and Minota, S., 1975, The direct action of adrenaline on the action potentials ofbullfrog’s sympathetic ganglion cells, Experientia 31:822–823.

    Article  PubMed  CAS  Google Scholar 

  • Laitinen, A., Partanen, M., Hervonen, A., and Laitinen, L. A., 1985, Electron microscopic study on the innervation of the human lower respiratory tract: Evidence of adrenergic nerves, Eur. J.Respir. Dis. 67:209–215.

    PubMed  CAS  Google Scholar 

  • Leff, A. R., Munoz, N. M., and Hendrix, S. G., 1983, Parasympathetic and adrenergic contractileresponses in canine trachea and bronchus, J. Appl. Physiol. 55:113–120.

    PubMed  CAS  Google Scholar 

  • Lichtman, J. W., 1980, On the predominantly single innervation of submandibular ganglion cells inthe rat, J. Physiol. (Lond.) 302:121–130.

    CAS  Google Scholar 

  • Lichtman, J. W., Purves, D., and Yip, J. W., 1979, On the purpose of selective innervation ofguinea-pig superior cervical ganglion cells,J. Physiol. (Lond.) 292:69–84.

    CAS  Google Scholar 

  • Lundberg, J. M., and Hokfelt, T., 1983, Coexistence of peptides and classification of neurotransmitters, Trends Neurosci.6:325–333.

    Article  CAS  Google Scholar 

  • Lundberg, J. M., and Sana, A., 1982, Bronchial smooth muscle contraction induced by stimulation of capsaicin-sensitive sensory neurons, Acta Physiol. Scand. 116:473–476.

    Article  PubMed  CAS  Google Scholar 

  • Lundberg, j. M., Sana, A., Brodin, E., Rosell, S., and Folkers, K., 1983, A substance P antagonist inhibits vagally induced increase in vascular permeability and bronchial smooth muscle contraction of the guinea pig, Proc. Natl. Acad. Sci. USA 80:1120–1124.

    Article  PubMed  CAS  Google Scholar 

  • Mann, S., 1971, The innervation of mammalian bronchial smooth muscle: The localization of catecholamines and cholinesterases, Histochem. J. 3:319–331.

    Article  PubMed  CAS  Google Scholar 

  • Matsuzaki, Y., Hamasaki, Y., and Said, S. I., 1980, Vasoactive intestinal peptide: A possible transmitter of nonadrenergic relaxation of guinea pig airways, Science 210:1252–1253.

    Article  PubMed  CAS  Google Scholar 

  • Middendorf, W. F., and Russell, J. A., 1980, Innervation of airway smooth muscle in the baboon. Evidence for a nonadrenergic inhibitory system, J. Appl. Physiol. 48:947–956.

    PubMed  CAS  Google Scholar 

  • Minette, P. A., and Barnes, P. J., 1988, Prejunctional inhibitory muscarinic receptors on cholinergic nerves in human and guinea pig airways, J. Appl. Physiol. 64:2532–2537.

    PubMed  CAS  Google Scholar 

  • Mitchell, R. A., Herbert, D. A., Baker, D. G., and Basbaum, C. B., 1987, In vivo activity of tracheal parasympathetic ganglion cells innervating tracheal smooth muscle, Brain Res. 437: 157–160.

    Article  PubMed  CAS  Google Scholar 

  • Nishi, S., and Christ, D. D., 1971, Electrophysiological and anatomical properties of mammalian parasympathetic ganglion cells, in: Proceedings of the International Union of Physiological Sciences, Vol. 9, pp. 421–431, German Physiological Society, Munich.

    Google Scholar 

  • North, R. A., 1973, The calcium-dependent slow after hyperpolarization in myenteric neurons with TTX-resistant action potentials, Br. J. Pharmacol. 49:709–711.

    PubMed  CAS  Google Scholar 

  • O’Donnell, S. R., and Saar, N., 1973, Histochemical localization of adrenergic nerves in the guinea pig trachea, Br. J. Pharmacol. 47:707–710.

    PubMed  Google Scholar 

  • Ohta, Y., and Koketsu, K., 1984, Histamine as an endogenous antagonist of nicotinic Ach-receptor, Brain Res. 306:370–373.

    Article  PubMed  CAS  Google Scholar 

  • Pennefather, P., Lancaster, B., Adams, P. R., and Nicoll, R. A., 1985, Two distinct Ca-dependent K currents in bullfrog sympathetic ganglion cell, Proc. Nat. Acad. Sci. USA 82:3040–3042.

    Article  PubMed  CAS  Google Scholar 

  • Purves, D., and Wigston, D. J., 1983, Neural units in the superior cervical ganglion of the guinea-pig, J. Physiol. (Lond.) 334:169–178.

    CAS  Google Scholar 

  • Richardson, J., and Beland, J., 1976, Nonadrenergic inhibitory nerves in human airways, J. Appl. Physiol. 41:764–771.

    PubMed  CAS  Google Scholar 

  • Russell, J. A., 1978, Responses of isolated canine airways to electrical stimulation and acetylcholine, J. Appl. Physiol. 45:690–698.

    PubMed  CAS  Google Scholar 

  • Russell, J. A., and Bartlett, J., 1981, Adrenergic neurotransmission in airways: Inhibition by acetylcholine, J. Appl. Physiol. 52:376–383.

    Article  Google Scholar 

  • Russell, J. A., and Simon, E. J., 1985, Modulation of cholinergic neurotransmission in airways by enkephalin, J. Appl. Physiol. 58:853–858.

    PubMed  CAS  Google Scholar 

  • Seria, R., and Daniel, E. E., 1988, Thromboxane effect on canine trachealis neuromuscular function, J. Appl. Physiol. 64:1979–1988.

    Google Scholar 

  • Sheller, J. R., Holtzman, J. J., Skoogh, B. E., and Nadel, J. A., 1982, Interaction of serotonin with vagal and acetylcholine induced bronchoconstriction in canine lungs, J. Appl. Physiol. 52:964–966.

    PubMed  CAS  Google Scholar 

  • Simonds, W. F., Booth, A. M., Thor, K. B., Ostrowski, N. L., Nagel, J. R., and DeGroat, W. C, 1983, Parasympathetic ganglia: Naloxone antagonizes inhibition by leucine-enkephalin and GABA, Brain Res. 271:365–370.

    Article  PubMed  CAS  Google Scholar 

  • Skoogh, B. E., 1986, Transmission through airways ganglia, Eur. J. Respir. Dis. 131(Suppl.):159–170.

    Google Scholar 

  • Suzuki, T., and Kusano, K., 1978, Hyperpolarizing potentials induced by Ca-mediated K conduction increase in hamster submandibular ganglion cells, J. Neurobiol. 9:367–392.

    Article  PubMed  CAS  Google Scholar 

  • Tamura, K., Palmer, J. M., and Wood, J. D., 1988, Presynaptic inhibition produced by histamine atnicotinic synapses in enteric ganglia, Neurosci.25:171–179.

    Article  CAS  Google Scholar 

  • Tanaka, D. T., and Grunstein, M. D., 1984, Mechanisms of substance P-induced contraction ofrabbit airway smooth muscle, J. Appl. Physiol. 57:1551–1557.

    PubMed  CAS  Google Scholar 

  • Uddman, R. J., Aluments, J., Senset, O., Hakanson, R., and Sundler, F., 1978, Occurrence anddistribution of VIP nerves in the nasal mucosa and tracheal-bronchial wall, ActaOtolaryngol.(Stockh.) 86:433–448.

    Google Scholar 

  • Vanhoutte, P. M., Verbeurent, J., and Webb, R. C, 1981, Local modulation of adrenergic neuroeffector interactions in the blood vessel wall, Physiol. Rev. 61:151–247.

    PubMed  CAS  Google Scholar 

  • Walters, E. H., O’Bryne, P. M., Fabbri, L. M., Graf, P. D., Holtzman, M. J., and Nadel, J. A.,1984, Control of neurotransmission by prostaglandins in canine tracheaiis smooth muscle, J.Appl. Physiol. 57:128–134.

    Google Scholar 

  • Wood, J. D., 1984, Enteric neurophysiology, Am. J. Physiol. 247:G585–598.

    PubMed  CAS  Google Scholar 

  • Yip, P., Palombini, B., and Coburn, R. F., 1981, Inhibitory innervation to the guinea pig tracheaiismuscle, J. Appl. Physiol. 50:374–382.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Plenum Press, New York

About this chapter

Cite this chapter

Coburn, R.F. (1989). Integration of Neural Inputs in Peripheral Airway Ganglia. In: Coburn, R.F. (eds) Airway Smooth Muscle in Health and Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0779-2_2

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-0779-2_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8078-1

  • Online ISBN: 978-1-4613-0779-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics