Skip to main content

Exercise-Induced Bronchoconstriction

  • Chapter
  • 60 Accesses

Abstract

Shortness of breath during exercise is frequently observed in patients with different types of cardiac or pulmonary disease. The shortness of breath and bronchoconstriction that develop after short-term exercise is a characteristic clinical response that signifies airway hyperreactivity in patients with bronchial asthma. It is known as either exercise-induced asthma or exercise-induced bronchocon- striction (EIB), or both. Since this entity is characterized by bronchoconstriction, which can be objectively measured, and as the term asthma has a broader meaning, it is more appropriate to call this phenomenon exercise-induced bronchoconstriction.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ahonen, A., Sovijarvi, A. R. A., and Muittari, A., 1983, Plasma glucagon response during exercise-induced asthma, Eur. J. Respir. Dis. 64: 166–171.

    PubMed  CAS  Google Scholar 

  • Anderson, S. D., 1983, Recent advances in the understanding of exercise-induced asthma, Eur. J. Respir. Dis. 64: 225–236.

    Google Scholar 

  • Anderson, S. D., 1984, Is there a unifying hypothesis for exercise-induced asthma?, J. Allergy Clin. Immunol. 73: 660–665.

    Article  PubMed  CAS  Google Scholar 

  • Anderson, S. D., Silverman, M., Konig, P., and Godfrey, S., 1975, Exercise induced asthma, Br. J. Dis. Chest 69: 1–17.

    Article  PubMed  CAS  Google Scholar 

  • Anderson, S. D., Poser, R., Smith, I. D., and Temple, D., 1976, Exercise-related changes in plasma levels of 15-keto-13, 14-dihydro-prostaglandin F2 and noradrenaline in asthmatic and normal subjects, Scand. J. Respir. Dis. 57: 41–48.

    PubMed  CAS  Google Scholar 

  • Anderson, S. D., Bye, P. T. P., Schoeffel, R. E., Seale, J. P., Taylor, K. M., and Ferris, L., 1981, Arterial plasma histamine levels at rest and during and after exercise in patients with asthma: Effect of terbutaline aerosol, Thorax 36: 259–267.

    Article  PubMed  CAS  Google Scholar 

  • Anderson, S. D., 1985, Issues in exercise-induced asthma, J. Allergy Clin. Immunol. 76: 764–772.

    Google Scholar 

  • Anderson, S. D., Schoeffel, R. E., Black, J. L., and Daviskas, E., 1985, Airway coding and the stimulus to exercise-induced asthma—A re-evaluation, Eur. J. Respir. Dis. 67: 20–30.

    PubMed  CAS  Google Scholar 

  • Atkins, P. C., Nordan, M., Weiner, H., and Zweim, B., 1977, Release of neutrophil chemotactic activity during immediate hypersensitivity reactions in humans, Arch. Intern. Med. 86: 415–420.

    CAS  Google Scholar 

  • Barnes, P. J., and Brown, M. J., 1981, Venous plasma histamine in exercise and hyperventilation-induced asthma in man, Clin. Sci. 61: 159–162.

    PubMed  CAS  Google Scholar 

  • Bar-Or, O., Neuman, L., and Dothan, R., 1977, Effects of drug and humid climates on exercise- induced asthma in children and adolescents, J. Allergy Clin. Immunol. 60: 163–168.

    Article  PubMed  CAS  Google Scholar 

  • Beil, M., and DeKock, M. A., 1978, Role of alpha-adrenergic receptors in exercise-induced bronchoconstriction, Respiration 35: 78–86.

    Article  PubMed  CAS  Google Scholar 

  • Bierman, C. W., 1984, A comparison of late reactions to antigen and exercise, J. Allergy Clin. Immunol. 73: 654–659.

    Article  PubMed  CAS  Google Scholar 

  • Bleecker, E. R., Chahal, K. S., Mason, P., and Permutt, S., 1983, The effect of alpha adrenergic blockage on non-specific airway reactivity and exercise-induced asthma, Eur. J. Respir. Dis. 64: 258–264.

    Google Scholar 

  • Buckley, J. M., Souhrada, J. F., and Kopetzky, M. T., 1974, Detection of Airway obstruction in exercise-induced asthma, Chest 66: 244–251.

    Article  PubMed  CAS  Google Scholar 

  • Chang-Yeung, M. M. W., Vyas, M. N., and Gryzbowski, S., 1971, Exercise-induced asthma, Am. Rev. Respir. Dis. 104: 915–923.

    Google Scholar 

  • Chen, W. Y., Horton, D. J., and Souhrada, J. F., 1976, Respiratory tract and water loss and exercise-induced asthma, Physiologist 19: 152 (abstr.).

    Google Scholar 

  • Chryssanthopoulos, C., Maksud, M. G., Funahashi, A., Hoffmann, R. G., and Barboriak, J. J., 1979, An assessment of cardiorespiratory adjustments of asthmatic adults to exercise, J. Allergy Clin. Immunol. 63: 321–327.

    Article  PubMed  CAS  Google Scholar 

  • Coburn, R. F., and Soltoff, S., 1977, Na+-K+-ATPase inhibition stimulates PgE release in guinea pig taenia coli, Am. J. Physiol. 232: C191–C195.

    PubMed  CAS  Google Scholar 

  • Empey, D. W., Laitinen, L. A., Jacobs, L., Gold, W. M., and Nadel, J. A., 1976, Mechanisms of bronchial hyperactivity in normal subjects after upper respiratory tract infection, Am. Rev. Respir. Dis. 113: 131–139.

    PubMed  CAS  Google Scholar 

  • Enright, P. L., McNally, J. F., and Souhrada, J. F., 1980, Effect of lidocaine on the ventilatory and airway responses to exercise in asthmatics, Am. Rev. Respir. Dis. 122: 823–828.

    PubMed  CAS  Google Scholar 

  • Godfrey, S., and Mearns, M., 1971, Pulmonary function and response to exercise in cystic fibrosis, Arch. Dis. Child. 46: 144–152.

    Article  PubMed  CAS  Google Scholar 

  • Godfrey, S., Silverman, M., and Anderson, S. A., 1973, Problems of interpreting exercise-induced asthma, J. Allergy Clin. Immunol. 52: 199–209.

    Article  PubMed  CAS  Google Scholar 

  • Gross, G. N., Souhrada, J. F., and Farr, R. S., 1974, Long-term treatment of an asthmatic patient using phentolamine, Chest 66: 397–401.

    Article  PubMed  CAS  Google Scholar 

  • Hahn, A., Anderson, S. D., Morton, A. R., Black, J. L., and Fitch, K. D., 1984, A reinterpretation of the effect of temperature and water content of the inspired air in exercise-induced asthma, Am. Rev. Respir. Dis. 130: 575–579.

    PubMed  CAS  Google Scholar 

  • Herxheimer, H., 1946, Hyperventilation asthma, Lancet 1: 87–89.

    Google Scholar 

  • Howarth, P. H., and Holgate, S. F., 1983, Exercise, asthma, and mast cells, Lancet 1:822 (abstr.).

    Article  PubMed  CAS  Google Scholar 

  • Iikura, Y., Inui, H., Nagakura, T., and Tak H. Lee, 1985, Factors predisposing to exercise-induced late asthmatic responses, J. Allergy Clin. Immunol 75289.

    Article  PubMed  CAS  Google Scholar 

  • Jaeger, M. J., Tribble, D., and Wittig, H. J., 1979, Effect of 0.5 ppm sulfur dioxide on the respiratory function of normal and asthmatic subjects, Lung 156: 119–224.

    Article  PubMed  CAS  Google Scholar 

  • Johnson, C. E., Belfield, P. W., Davis, S., Cooke, N. J., Spencer, A., and Davies, J. A., 1986, Platelet activation during exercise-induced asthma: Effect of prophylaxis with chlomoglycate and solbutabol. Thorax 41: 290–298.

    Article  PubMed  CAS  Google Scholar 

  • Jones, R. S., 1966, Assessment of respiratory function in the asthmatic child, Br. Med. J. 2: 972–975.

    Article  PubMed  CAS  Google Scholar 

  • Kattan, M., Keens, T. G., Mellis, C. M., and Levison, H., 1978, The response to exercise in normal and asthmatic children, J. Pediatr. 92: 718–721.

    Article  PubMed  CAS  Google Scholar 

  • Katz, R. M., Whipp, B. J., Heimlich, E. M., and Wasserman, K., 1971, Exercise-induced bronchospasm, ventilation and blood gases in asthmatic children, J. Allergy 47: 148–158.

    PubMed  CAS  Google Scholar 

  • Kay, A. B., and Lee, T. H., 1983, Mediators of hypersensitivity in exercise induced asthma, Eur. J. Respir. Dis. 64: 237–241.

    Google Scholar 

  • Kawabori, S., Pierson, W. E., and Conquest, C. W., 1976, Incidence of exercise-induced asthma in children, J. Allergy Clin. Immunol. 58: 447–455.

    Article  PubMed  CAS  Google Scholar 

  • Kneussel, M. P., and Richardson, J. B., 1978, Alpha-adrenergic receptors in human and canine tracheal and bronchial smooth muscle, J. Appl. Physiol. 45: 307–311.

    Google Scholar 

  • Konig, P., Godfrey, S., and Abrahamov, A., 1972, Exercise-induced bronchial lability in children with a history of wheezy bronchitis, Arch. Dis. Child. 47: 578–580.

    Article  PubMed  CAS  Google Scholar 

  • Laitinen, L. A., and Kokkola, K., 1974, Bronchial reactivity to histamine in pulmonary tuberculosis, Scand. J. Respir. Dis. 89(Suppl.):201–205.

    CAS  Google Scholar 

  • Lee, T. H., and Anderson, S. D., 1985, Heterogeneity of mechanism in exercise-induced asthma, Thorax 40: 481–489.

    Article  PubMed  CAS  Google Scholar 

  • Lee, T. H., Nagy, L., Nagakura, T., Walport, M. J., and Kay, A. B., 1982, Identification and partial characterization of a exercise-induced neutrophil chemotactic factor in bronchial asthma, J. Clin. Invest. 69: 889–899.

    Article  PubMed  CAS  Google Scholar 

  • Lee, T. H., Nagakura, T., Papageorgiou, N., Iikura, Y., and Kay, A. B., 1983, Exercise-induced late asthmatic reactions with neutrophil chemotactic activity, N. Engl. J. Med. 308: 1502–1505.

    Article  PubMed  CAS  Google Scholar 

  • Lee, T. H., Nagakura, T., Papageorgio, N., Cromwell, O., Iikura, Y., and Kay, A. B., 1984, Mediators in exercise-induced asthma, J. Allergy Clin. Immunol. 73: 634–639.

    Article  PubMed  CAS  Google Scholar 

  • Lefcoe, N. M., 1969, The time course of maximum ventilatory performance during and after moderately heavy exercise, Clin. Sci. 36: 47–52.

    PubMed  CAS  Google Scholar 

  • Mansfield, L., McDonnell, J., Morgan, W., and Souhrada, J. F., 1979, Airway response in asth- matic children during and after exercise, Respiration 38: 135–143.

    Article  PubMed  CAS  Google Scholar 

  • McFadden, E. R., Jr., Sterns, D. S., Ingram, R. H., Jr., and Leith, D. E., 1977, Relative contribu- tions of hypocapnia and hyperpnea as mechanisms in a post-exercise asthma, J. Appl. Physiol. 42: 22–27.

    PubMed  Google Scholar 

  • McFadden, R. E., Jr., Denison, D. M., Walker, J. F., Assoufi, B., Peacock, A., and Sopwith, T., 1982, Direct recording of the temperature in the tracheobronchial tree in normal man, J. Clin. Invest. 69: 700–705.

    Article  PubMed  Google Scholar 

  • McNally, J. F., Jr., Enright, P., Hirsh, J. E., and Souhrada, J. F., 1979, The attenuation of exercise- induced bronchoconstriction by oropharyngeal anesthesia, Am. Rev. Resp. Dis. 119: 247–252.

    PubMed  Google Scholar 

  • Murlas, C., Tencati, J., Mahutte, K., Nadel, J. A., and Roberts, J. M., 1982, Direct effect of cooling on human bronchial smooth muscle, Am. Rev. Resp. Dis. 125: 222a.

    Google Scholar 

  • Nadel, J. A., 1984, Inflammation and asthma, J. Allergy Clin. Immunol. 73: 651–653.

    Article  PubMed  CAS  Google Scholar 

  • Nagakura, T., Lee, T. H., Assoufi, B. K., Denison, D. M., Newman-Taylor, A. J., and Kay, A. B., 1983, Neutrophil chemotactic factor in exercise and hyperventilation-induced asthma, Am. Rev. Resp. Dis. 128: 294–296.

    PubMed  CAS  Google Scholar 

  • Nagy, L., Lee, T. H., and Kay, A. B., 1982, Neutrophil chemotactic activity in antigen-induced late asthmatic reactions, N. Engl. J. Med. 306: 496–501.

    Article  Google Scholar 

  • Neuman, I., Inbar, O., and Creter, D., 1983, The kinin system in exercise-induced asthma, Am. Allergy 53: 351–354.

    Google Scholar 

  • Ouellette, J. J., and Reed, E., 1965, Increased response of asthmatic subjects to methacholine after influenza vaccine, J. Allergy 36: 558–563.

    Article  PubMed  CAS  Google Scholar 

  • Orehek, J., Massari, J. P., Gayrard, P., Grimaud, C., and Charpin, J., 1976, Effect of short-term, low-level nitrogen dioxide exposure on bronchial sensitivity of asthmatic patients, J. Clin. Invest. 57: 301–307.

    Article  PubMed  CAS  Google Scholar 

  • Papageorgio, N., Durham, S. R., Walsh, G. M., Carroll, M., Lee, T. H., and Kay, A. B., 1983, Complement receptor enhancement as evidence of neutrophil activation after exercise-induced asthma, Lancet 2: 1220–1222.

    Article  Google Scholar 

  • Park, M. K., Hayashi, S., Wise, F. M., and Robotham, J. L., 1982, Mechanism of cooling-induced contraction of isolated tracheal smooth muscle, Fed. Proc. 41: 1356a.

    Google Scholar 

  • Parker, C. D., Bilbo, R. E., and Reed, C. E., 1965, Methalcholine aerosol as test for bronchial asthma, Arch. Int. Med. 115: 452–460.

    CAS  Google Scholar 

  • Rebuck, A. S., and Reed, J., 1968, Exercise-induced asthma, Lancet 2: 429–431.

    Article  PubMed  CAS  Google Scholar 

  • Sheppard, D., Epstein, J., Holtzman, M. J., Nadel, J. A., and Boushey, H. A., 1982, Dose- dependent inhibition of cold air-induced broncho-constriction by atropine, J. Appl. Physiol. 53: 169–174.

    PubMed  CAS  Google Scholar 

  • Shturman-Ellstein, R., Zeballos, R. J., Buckley, J. M., and Souhrada, J. F., 1978, The beneficial effect of nasal breathing on exercise-induced bronchoconstriction, Am. Rev. Resp. Dis. 118: 65–73.

    PubMed  CAS  Google Scholar 

  • Silverman, M., Anderson, S. D., and Walker, S. R., 1972, Metabolic changes preceeding exercise- induced bronchoconstriction, Br. Med. J. 1: 207–209.

    Article  PubMed  CAS  Google Scholar 

  • Silverman, F., 1979, Asthma and respiratory irritants (ozone), Environ. Health Perspect. 29: 131–136.

    Article  PubMed  CAS  Google Scholar 

  • Simonsson, B. G., 1965, Clinical and physiological studies on chronic bronchitis. III. Bronchial reactivity to inhaled acetylcholine, Acta Allergol. 20: 325–348.

    PubMed  CAS  Google Scholar 

  • Simonsson, B. G., Jacobs, F. J., and Nadel, J. A., 1967, Role of autonomic nervous system and the cough reflex in the increased responsiveness of airway in patients with obstructive airway disease, J. Clin. Investig. 46: 1812–1820.

    Article  PubMed  CAS  Google Scholar 

  • Simonsson, B. G., Skoogh, B. E., and Ekstrom-Jodal, B., 1972, Exercise-induced airways constriction, Thorax 27: 169–180.

    Article  PubMed  CAS  Google Scholar 

  • Soltoff, S., Carcillo, T., and Coburn, R. F., 1979, Zero extracellular K+ and Prostaglandine release in the guinea pig taenia coli, Biochim. Biophys. Acta. 557: 217–229.

    Article  PubMed  CAS  Google Scholar 

  • So, S. Y., Lam, W. K., and Kwan, S., 1985, Selective 5-HT2 receptor blockage in exercise-induced asthma, Clin. Allergy 15: 371–386.

    Article  PubMed  CAS  Google Scholar 

  • Souhrada, M., and Souhrada, J. F., 1981, The direct effect of temperature on airway smooth muscle, Resp. Physiol. 44: 311–323.

    Article  CAS  Google Scholar 

  • Souhrada, J. F., Presley, D., and Souhrada, M., 1983, Mechanisms of the temperature effect on airway smooth muscle, Resp. Physiol. 53: 225–237.

    Article  CAS  Google Scholar 

  • Stanescu, D. C., and Teculescu, D. B., 1970, Exercise and cough-reduced asthma, Respiration 27: 377–402.

    Article  PubMed  CAS  Google Scholar 

  • Vassallo, C. L., Gee, J. B. L., and Domm, B. M., 1972, Exercise-induced asthma: observations regarding hypocapnia and acidosis, Am. Rev. Resp. Dis. 105: 42–49.

    PubMed  CAS  Google Scholar 

  • Waiden, S. M., Bleecker, E. R., Chahal, K., Britt, J., Mason, P., and Permutt, S., 1984, Effect of alpha-adrenergic blockage on exercise-induced asthma and conditioned cold air, Am. Rev. Resp. Dis. 130: 357–362.

    Google Scholar 

  • Zawadski, D. K., Lenner, K. A., and McFadden, E. R., Jr., 1988, Re-examination of the late asthmatic response to exercise, Am. Rev. Resp. Dis. 137: 837–841.

    PubMed  CAS  Google Scholar 

  • Zeballos, R. J., Shrurman-Ellstein, R., McNally Jr., J. F., Hirsh, J. E., and Souhrada, J. F., 1978, The role of hyperventilation in exercise-induced bronchoconstriction, Am. Rev. Resp. Dis. 118: 877–884.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Plenum Press, New York

About this chapter

Cite this chapter

Souhrada, J.F. (1989). Exercise-Induced Bronchoconstriction. In: Coburn, R.F. (eds) Airway Smooth Muscle in Health and Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0779-2_15

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-0779-2_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8078-1

  • Online ISBN: 978-1-4613-0779-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics