Autoantibodies to Myelin Basic Protein In Multiple Sclerosis

  • K. G. Warren
  • I. Catz


Multiple sclerosis (MS) was initially described in the nineteenth century in Europe and subsequently in North America. The diary and letters of Sir Augustus Frederick d’Este (1794–1848), the grandson of George III of England and a cousin of Queen Victoria, illustrate the earliest personal description of this disease. Over a period of 28 years he experienced recurring symptoms including blurring of vision, numbness of limbs, loss of balance, bladder and bowel disturbances, staggering gait and finally paralysis, all highly characteristic of the clinical course of MS (21). The Parisian physician Jean Martin Charcot (1825–1893) and his colleague Vulpian are generally given the credit for bringing this unique disease to the attention of the medical community and separating it form the multitude of undifferentiated paralytic disorders of that era (16). Attempts to understand the etiology-pathogenesis of this disease must consider the following facts:
  1. (a)

    MS as a clinical-pathological entity has been known for close to 200 years and therefore its precipitating factor(s) must have been present for an equal period of time.

  2. (b)

    MS is an inflammatory-demyelinating disease with associated gliosis and relative neuronal-axonal sparing, which is restricted to the central nervous system (CNS) of human beings.



Multiple Sclerosis Multiple Sclerosis Patient Myelin Basic Protein Optic Neuritis Albumin Ratio 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • K. G. Warren
    • 1
  • I. Catz
    • 1
  1. 1.Multiple Sclerosis Care and Research Clinic Division of NeurologyUniversity of AlbertaEdmontonCanada

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