Wall-Associated Antigens of Coccidioides Immitis

  • Garry T. Cole
  • S. H. Sun
  • J. Dominguez
  • L. Yuan
  • M. Franco
  • T. N. Kirkland


The cell wall of most pathogenic fungi has been shown to be a reservoir of immunoreactive macromolecules (Hall et al., 1978, San Bias, 1982, 1985; Huppert, 1983, Hearn, 1984; Brawner and Cutler, 1986a,b; Ponton and Jones, 1986). Coccidioides immitis, causative agent of ‘valley fever’ (coccidioidomycosis), is an almost ideal model for investigating the importance of wall-associated antigens to host response. Evidence has been presented that clinically significant biological activities are elicited in laboratory animals by their exposure to the fungal cell wall or solubilized wall extracts of C. immitis. For example, animals exposed to wall products have exhibited delayed-type hypersensitivity, (Ward et al., 1975), production of macrophage migration inhibition factor and lymphocyte transformation, (Cox and Vivas, 1977, Cox et al., 1981), immunoprotection against intranasal challenge, (Lecara et al., 1983), and response of both tube precipitin and complement-fixing antibodies (Collins et al., 1977).


Reference System Elution Profile Wall Fraction Normal Human Serum HPLC Fraction 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Garry T. Cole
    • 1
  • S. H. Sun
    • 2
  • J. Dominguez
    • 2
  • L. Yuan
    • 1
  • M. Franco
    • 4
  • T. N. Kirkland
    • 3
  1. 1.Department of BotanyUniversity of TexasAustinUSA
  2. 2.Veterans Administration HospitalSan AntonioUSA
  3. 3.San DiegoCaliforniaUSA
  4. 4.Estadual PaulistaBotucatuBrazil

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