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Allergens of Aspergillus Fumigatus

  • Chapter
Fungal Antigens

Abstract

The word ‘allergen’ was originally introduced to indicate any substance that gave rise to an immunologically altered response i.e. any of the four types of specific hypersensitivity reactions as defined by Gell & Coombs (1975). However, more recently the word has become synonymous with “atopic allergen” meaning those substances that give rise to Type I immediate hypersensitivity reactions mediated by IgE antibody, i.e. “antigens that react with IgE antibodies”.

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References

  • Bengtsson, A., Karlsson, A., Rolfsen, W., and Einarsson R., 1986, Detection of allergens in mould and mite preparations by a nitrocellulose electroblotting technique, Int. Archs Allergy appl. Immunol., 80:383.

    Article  CAS  Google Scholar 

  • Biguet, J., Tran Van Ky, P., Fruit, J., and Andrieux, S., 1967, Identification d’une activité chymotrypsique au niveau de fractions remarkables de ’extrait antigenique d’Aspergillus fumigatus. Répercussions sur le diagnostic immunologique de ’aspergillose, Revue d’Immunologie, 31:317.

    CAS  Google Scholar 

  • Calvanico, N.J., Dupont, B.L., Huang, C.J., Patterson, R., Fink, J.N., and Kurup, V.P., 1981, Antigens of Aspergillus fumigatus I. Purification of a cytoplasmic antigen reactive with sera of patients with Aspergillus related disease, Clin. Exp. Immunol., 45:662.

    PubMed  CAS  Google Scholar 

  • Coombs, R.R.A., and Gell, P.G.H., 1975, Classification of allergic reactions responsible for clinical hypersensitivity and disease, in: “Clinical Aspects of Immunology” 3rd edition, chapter 25, P.G.H. Gell, R.R.A. Coombs, and P.J. Lachmann, eds., Blackwells, Oxford.

    Google Scholar 

  • Dessaint, J.P., Bout, D., Fruit, J., and Capron, A., 1976, Serum concentrations of specific IgE antibody against Aspergillus fumigatus and identification of the fungal allergen, Clin. Immunol. Immunopathol., 5:314.

    Article  PubMed  CAS  Google Scholar 

  • Harvey, C., and Longbottom, J.L., 1986a, Characterization of a major antigenic component of Aspergillus fumigatus, Clin. Exp. Immunol. 65:206.

    PubMed  CAS  Google Scholar 

  • Harvey, C., and Longbottom, J.L., 1986b, Development of a sandwich ELISA to detect IgG and IgG subclass antibodies specific for a major antigen (Ag 7) of Aspergillus fumigatus, Clin. Allergy, 16:323.

    Article  PubMed  CAS  Google Scholar 

  • Harvey, C., Shaw, R.J., and Longbottom J.L., Diagnostic specificity of a sandwich ELISA for Aspergillus-related diseases. J. Allergy Clin. Immunol, (in press).

    Google Scholar 

  • Hearn, V.M., and Mackenzie, D.W.R., 1980, Mycelial antigens from two strains of Aspergillus fumigatus an analysis by two-dimensional Immunoelectrophoresis, Mykosen, 23:549.

    PubMed  CAS  Google Scholar 

  • Hearn, V.M., Wilson, E.V., Proctor, A.G., and Mackenzie, D.W.R., 1980, Preparation of Aspergillus fumigatus antigens and their analysis by two-dimensional immunoelectrophoresis, J. med. Microbiol., 13:451.

    Article  PubMed  CAS  Google Scholar 

  • Kauffman, H.F., Van der Heyden, P.J., Van der Laan, S., Van der Heide, S., Beaumont, F., and de Vries, K., 1985a, Antibody determination against Aspergillus fumigatus by means of enzyme-linked immunosorbent assay. II. Physico- and immunochemical properties of the polystyrene-binding components, Int. Archs Allergy appl. Immunol., 78:174.

    Article  CAS  Google Scholar 

  • Kauffman, H.F., Van der Heide, S., Van der Laan, S., Hovenga, H., Beaumont, F., and de Vries, K., 1985b, Standardization of allergenic extracts of Aspergillus fumigatus. Liberation of IgE binding components during cultivation, Int. Archs Allergy appl. Immunol., 76:168.

    Article  CAS  Google Scholar 

  • Kauffman, H.F., Van der Heide, S., Beaumont, F., Blok, H., and de Vries, K., 1986, Class-specific antibody determination against Aspergillus fumigatus by means of enzyme linked immunosorbent assay. III. Comparative study: IgG, IgA, IgM ELISA titres precipitating antibodies and IgE binding after fractionation of the antigen, Int. Archs Allergy appl. Immunol., 80:300.

    Article  CAS  Google Scholar 

  • Kim, S.J., Chaparas S.D., Brown, T.M., and Anderson, M.C., 1978, Characterization of antigens from Aspergillus fumigatus. II. Fractionation and electrophoretic, immunologic and biologic activity, Am. Rev. Respir. Dis., 118:553.

    PubMed  CAS  Google Scholar 

  • Kurup, V.P., Ting, E.Y., and Fink, J.N., 1983, Immunochemical characterization of Aspergillus fumigatus antigens, Infect. Immun., 41:698.

    PubMed  CAS  Google Scholar 

  • Kurup, V.P., John, K.V., Rusnick, A., and Fink, J.N., 1986, A partially purified glycoprotein antigen from Aspergillus fumigatus, Int. Archs Allergy appl. Immunol., 79:263.

    Article  CAS  Google Scholar 

  • Longbottom, J.L., 1964, Immunological investigation of Aspergillus fumigatus in relation to disease in man, Ph.D. Thesis, University of London.

    Google Scholar 

  • Longbottom, J.L., 1983a, Antigens/allergens of Aspergillus fumigatus. Identification of antigenic components reacting with both IgG and IgE antibodies of patients with allergenic bronchopulmonary aspergillosis, Clin. Exp. Immunol., 53:354.

    PubMed  CAS  Google Scholar 

  • Longbottom, J.L., 1983b, Allergic bronchopulmonary aspergillosis. Reactivity of IgE & IgG antibodies with antigenic components of Aspergillus fumigatus (igE/lgG antigen complexes), J. Allergy Clin. Immunol., 72:668.

    Article  PubMed  CAS  Google Scholar 

  • Longbottom, J.L., 1986, Antigens and allergens of Aspergillus fumigatus II. Their further identification and partial characterization of a major allergen (Ag 3), J. Allergy Clin. Immunol., 78:18

    Article  PubMed  CAS  Google Scholar 

  • Longbottom, J.L., and Austwick P.K.C., 1986, Antigens and allergens of Aspergillus fumigatus I. Characterization by quantitative immunoelectrophoretic methods, J. Allergy Clin. Immunol., 78:9.

    Article  PubMed  CAS  Google Scholar 

  • Longbottom, J.L., and Pepys J.L. 1964, Pulmonary aspergillosis: Diagnostic and immunological significance of antigens and C-substance in Aspergillus fumigatus, J. Path. Bact., 88:141.

    Article  PubMed  CAS  Google Scholar 

  • Longbottom, J.L., and Pepys J.L., 1978, Immunological methods in mycology, in: “Handbook of Experimental Immunology” D.M. Weir, ed., 3rd edition, chapter 41, Blackwells, Oxford.

    Google Scholar 

  • Lowenstein H., 1978, Quantitative immunoelectrophonetic methods as a tool for the analysis and isolation of allergens, Progr. Allergy 25:1.

    CAS  Google Scholar 

  • De Magaldi S.W., and Mackenzie D.W.R., 1984, Specificity of antigens from pathogenic Aspergillus species II. Studies with ELISA and immunofluorescence, Sabouraudia: J. Med. Vet. Mycol., 22:381.

    Article  Google Scholar 

  • Mathews R., Burnie J.P., Fox A., Tabagchali S., 1985, Immunoblot analysis of serological responses in invasive aspergillosis. J. Clin. Pathol., 38:1300.

    Article  Google Scholar 

  • Nordvall S.L., Griminer, O., Karlsson, T., and Bjorkstén, B., 1982, Characterization of the mouse and rat IgE antibody responses to timothy pollen by means of crossed radio Immunoelectrophoresis, Allergy 37:259.

    Article  PubMed  CAS  Google Scholar 

  • Piechura J.E., Huang C.J., Cohen S.H., Kidd J.M., Kurup V.P., and Calvanico N.J., 1982, Antigens of Aspergillus fumigatus II Electrophoretic and clinical studies, Immunology 49:657.

    Google Scholar 

  • Platts-Mills T.A.E., 1982, Type I or immediate hypersensitivity: Hayfever and asthma, _in: “Clinical Aspects of Immunology” P.J. Lachmann and D.K. Peters, eds., 4th Edition, chapter 21, Blackwells, Oxford.

    Google Scholar 

  • Salvaggio J.L., and Aukrust L., 1981, Mold-induced asthma, J. Allergy Clin. Immunol., 68:327.

    Article  PubMed  CAS  Google Scholar 

  • Schonheyder H., and Anderson P., 1983, Determination of antibodies to partially purified Aspergillus antigens by an enzyme-linked immunosorbent assay, Int. Archs Allergy appl. Immunol. 70:108

    Article  CAS  Google Scholar 

  • Schonheyder H., and Anderson P., 1984, IgG antibodies to purified Aspergillus fumigatus antigens determined by enzyme linked immunosorbent assay, Int. Archs Allergy appl. Immunol., 74:262

    Article  CAS  Google Scholar 

  • Tran Van Ky P., Biguet J., and Fruit K., 1966, Localisation et frequence des arcs des immunoelectrophoregrammes produits de la serum des malades atteints de mycétomes aspergillaires appliquées contre ’antigène Aspergillus fumigatus, Revue d’ Immunologie 30:13.

    Google Scholar 

  • Wallenbeck I., Aukrust L., and Einarsson R., 1984, Antigenic variability of different strains of Aspergillus fumigatus, Int. Archs Allergy appl. Immunol., 73:166.

    Article  CAS  Google Scholar 

  • Weeke B., and Lowenstein H., 1973, Allergens identified in crossed radio-immunoelectrophonesis, Scand. J. Immunol., 2:149.

    Google Scholar 

  • Weiner M.H., and Coats-Stephen M., 1979, Immunodiagnosis of systemic aspergillosis. I. Antigenemia detected by radioimmunoassay in experimental infection, J. Lab. Clin. Med., 93:111.

    PubMed  CAS  Google Scholar 

  • Yarzâbal L.A., de Albornez M.B., de Cabrai N.A., and Satiago A.R., 1978, Specific double diffusion microtechnique for the diagnosis of aspergillosis and paracocudioidomycosis using monospecific antisera, Sabouraudia 16:55.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Allergy and Clinical Immunology, Cardiothoracic Institute, Brompton Hospital, Fulham Road, SW3 6HP, London, UK

    Joan L. Longbottom (Senior Lecturer)

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  1. Joan L. Longbottom
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Editor information

Editors and Affiliations

  1. Institut Pasteur, Paris, France

    Edouard Drouhet

  2. University of Texas, Austin, Texas, USA

    Garry T. Cole

  3. Sainte Justine Hospital, Montreal, Canada

    Louis de Repentigny

  4. Institut Pasteur, Paris, France

    Jean-Paul Latgé

  5. Institut Pasteur, Paris, France

    Bertrand Dupont

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© 1988 Plenum Press, New York

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Longbottom, J.L. (1988). Allergens of Aspergillus Fumigatus . In: Drouhet, E., Cole, G.T., de Repentigny, L., Latgé, JP., Dupont, B. (eds) Fungal Antigens. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0773-0_29

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  • DOI: https://doi.org/10.1007/978-1-4613-0773-0_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8075-0

  • Online ISBN: 978-1-4613-0773-0

  • eBook Packages: Springer Book Archive

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