Thyroid Hormone Transport from Blood into Brain Cells
The phenomenon of thyroid hormone transport encompasses a number of sequential steps beginning with their secretion by the thyroid follicles and ending with their distribution to multiple sites of metabolism and action within virtually all the body’s organs. These steps include equilibration with multiple carrier proteins in the plasma, transcapillary passage of both the hormones and the carrier proteins into extravascular spaces, entry into cells through their external membranes, and translocation to subcellular compartments and organelles. Some that are the subject of current inquiry or controversy, include the interaction of the hormones with “minor” transport protein in plasma, the kinetics of transcapillary movement, the presence of specific receptors for the carrier proteins and the hormones on endothelial and epithelial cell membranes, and specific transport mechanisms within cell organelles.
KeywordsIodine Iodide Folic Acid Cytosol Phenyl Alanine
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