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Thyroid Hormone Transport from Blood into Brain Cells

  • Jacob Robbins
  • Edison Goncalves
  • Mark Lakshmanan
  • Daniels Foti

Abstract

The phenomenon of thyroid hormone transport encompasses a number of sequential steps beginning with their secretion by the thyroid follicles and ending with their distribution to multiple sites of metabolism and action within virtually all the body’s organs. These steps include equilibration with multiple carrier proteins in the plasma, transcapillary passage of both the hormones and the carrier proteins into extravascular spaces, entry into cells through their external membranes, and translocation to subcellular compartments and organelles. Some that are the subject of current inquiry or controversy, include the interaction of the hormones with “minor” transport protein in plasma, the kinetics of transcapillary movement, the presence of specific receptors for the carrier proteins and the hormones on endothelial and epithelial cell membranes, and specific transport mechanisms within cell organelles.

Keywords

Thyroid Hormone Choroid Plexus Sodium Butyrate Mouse Neuroblastoma Mouse Neuroblastoma Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Jacob Robbins
    • 1
  • Edison Goncalves
    • 1
  • Mark Lakshmanan
    • 1
  • Daniels Foti
    • 1
  1. 1.Clinical Endocrinology Branch, NDDKNIHBethesdaUSA

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