Abstract
The sodium pump (Na,K-ATPase) is a plasma membrane bound enzyme found in all animal cells and subserves many specialized functions in nerve cells. It maintains transmembrane cationic gradients by pumping three sodiums out of the cell for two potassiums into the cell fueled by ATP hydrolysis (1). The resultant electrochemical gradients are crucial for normal neuronal activity, and drive the transport of nutrients and reuptake of neurotransmitters into the nerve cells (1, 2).
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Cantley, L.C. Structure and mechanism of (Na,K)-ATPase. Curr. Top. Bioenerg., 11:201–237, 1981
Iverson, L.L. and J.S. Kelly. Uptake and metabolism of aminobutyric acid by neurones and glial cells. Biochem. Pharmacol., 24:933-938, 1975
Shull, G.E., J. Greeb, and J.B. Lingrel. Molecular cloning of three distinct forms of the Na,K-ATPase alpha subunit from rat brain. Biochem. 25:8125–8132, 1986
Young, R.M., G.E. Shull and J.B. Lingrel. Multiple mRNAs from rat kidney and brain encode a single Na,K-ATPase beta subunit protein. J. Biol. Chem. 262: 4905 – 4910, 1987
Sweadner, K.J. Two molecular forms of Na,K-ATPase in brain J. Biol. Chem 2 5 4: 6060 – 6067, 1979
Valcana, T. and P.S. Timiras. Effect of hypothyroidism on ionic metabolism and Na-K activated ATP phosphohydrolase activity in the developing rat brain. J. Neurochem. 16: 935 – 943, 1969
Abdel-Latif, A.A., J. Brody, and H. Ramahi. Studies on sodium-potassium adenosine triphosphatase of the nerve endings and appearance of electrical activity in developing brain. J. Neurochem. 14: 1133 – 1141, 1967
Vernadakis,A. and Woodbury, D.M. Electrolyte and amino acid changes in rat brain during maturation. Am. J. Physiol. 203: 748 – 752, 1962
Schmitt, C.A. and A.A. McDonough. Developmental and thyroid hormone regulation of two molecular forms of Na,K-ATPase in brain. J. Biol. Chem. 2 61: 10439 – 10444, 1986
Ismail Beigi, F. and I.S. Edelman. The mechanism of the calorigenic action of thyroid hormone. J. Gen. Physiol. 52: 710 – 722, 1971
Lin, M.H.and T. Akera. Increased Na,K-ATPase concentrations in various tissues of rat caused by thyroid hormone treatment. J. Biol. Chem. 253:723’726
Schmitt, C.A. and A.A. McDonough. Thyroid hormone induces Na,K-ATPase during a critical period of development in neonatal rat brain. Fed. Proc. 46: 361, 1987
McDonough, A.A., T.A. Brown, B. Horowitz, R. Chiu, J. Schlotterbeck, J. Bowen, and C. Schmitt. Thyroid hormone coordinately regulates Na,K-ATPase alpha and beta subunit mRNA levels in kidney. Am. J. Physiol. 254:C323–C329, 1988
Bowen, J.W. and A.McDonough. Pretranslational regulation of Na,K-ATPase in cultured canine kidney cells by low K+. 252: C179–C189, 1987
Atterwill, C.K., D.J. Atkinson, I. Bermudez. Effect of thyroid hormone and serum on the development of Na,K-ATPase and associated ion fluxes in cultures from rat brain. Neurosci. 14: 361 – 373, 1985
Thompson,C.C., C. Weinberger, R. Lebo, and R.M. Evans. Identification of a novel thyroid hormone receptor expressed in the mammalian central nervous system. Science 237: 1610 – 1614, 1987
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© 1989 Plenum Press, New York
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McDonough, A., Schmitt, C. (1989). Developmental and Thyroid Hormone Regulation of Na,K-ATPase Isoforms in the Brain. In: DeLong, G.R., Robbins, J., Condliffe, P.G. (eds) Iodine and the Brain. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0765-5_12
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DOI: https://doi.org/10.1007/978-1-4613-0765-5_12
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