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Developmental and Thyroid Hormone Regulation of Na,K-ATPase Isoforms in the Brain

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Iodine and the Brain

Abstract

The sodium pump (Na,K-ATPase) is a plasma membrane bound enzyme found in all animal cells and subserves many specialized functions in nerve cells. It maintains transmembrane cationic gradients by pumping three sodiums out of the cell for two potassiums into the cell fueled by ATP hydrolysis (1). The resultant electrochemical gradients are crucial for normal neuronal activity, and drive the transport of nutrients and reuptake of neurotransmitters into the nerve cells (1, 2).

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© 1989 Plenum Press, New York

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McDonough, A., Schmitt, C. (1989). Developmental and Thyroid Hormone Regulation of Na,K-ATPase Isoforms in the Brain. In: DeLong, G.R., Robbins, J., Condliffe, P.G. (eds) Iodine and the Brain. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0765-5_12

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  • DOI: https://doi.org/10.1007/978-1-4613-0765-5_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8071-2

  • Online ISBN: 978-1-4613-0765-5

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