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Preliminary Evaluation and Report on Human Adrenal Medullary Grafting

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Abstract

“Brain Transplantation” is an area of high interest and heightened activity by neuroscientists, neurosurgeons, and neurologists. It has been called the “ultimate transplant” which reflects its perceived importance and utility. This is, in fact, a misnomer since the brain is not actually being transplanted but rather small fragments of neural tissue are being grafted into the brain. A specific tissue is being utilized to correct a specific deficit. Thus, for Parkinson’s disease, dopamine producing tissue is placed in the striatum. While the procedure is still capable of producing front page news, the technical aspects of the surgery are embarrassingly simple. Most of the sophistication resides in the knowing of who should have surgery, when in the course of the disease surgery should be performed, what tissue should be used, where the tissue should be placed, and how best to place the tissue. Incredibly, none of these issues have been totally resolved.

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References

  1. Freed, W.J.: Functional Brain Tissue Transplantation: reversal of lesion-induced rotation by intraventricular substantia nigra and adrenal medulla grafts, with a note on intracranial retinal grafts. Biological Psychiatry, 18: 1205–1267, 1983.

    PubMed  CAS  Google Scholar 

  2. Stromberg, I., Herrera-Marchitz, M., Ungerstedt, U., Ebendal, T., Olson, L.: Chronic implants of chromaffin tissue into the dopamine-denervated striatum. Effects of NGF on graft survival, fiber growth and rotational behavior. Exp Brain Res. 60: 335–349, 1985.

    Article  PubMed  CAS  Google Scholar 

  3. Perlow, M.J.: Brain grafting, in Koller, W.C. (Ed): Handbook of Parkinson’s Disease, Marcel Dekker, Inc., 1987, pp 437–454.

    Google Scholar 

  4. Backlund, E-O., Granberg, P.O., Hamberger, B., Knutsson, E., Martenson, A., Sedvall, G., Seiger, A., Olson, L.: Transplantation of adrenal medullary tissue to striatum in parkinsonism. First clinical trials. J Neurosurg. 62: 169–173, 1985.

    Article  PubMed  CAS  Google Scholar 

  5. Olson L., Backlund, E-O., Gerhardt, G., Hoffer, B., Lindvall, O., Rose, G., Seiger, A., Stromberg, I.: Nigral and adrenal grafts in parkinsonism: recent basic and clinical studies, in Yahr, M.D., Bargmann, K.J. (Eds): Advances in Neurology, 1986, 45: 85–94.

    Google Scholar 

  6. Lindvall, O., Olson, L., Seiger, A., Backlund, E-O.: Towards a transplantation therapy in parkinson’s disease: a progress report from ongoing clinical experiments. II. Neurological Assessment, in Azmitia, E., Bjorklund, A. (Eds): Cell and Tissue Transplantation into the Adult Brain. New York, New York Academy of Sciences, 1986, pp 568–673.

    Google Scholar 

  7. Madrazo, I., Drucker-Colin, R., Diaz, V., Martinez-Mata, J., Torres, C., Becerril, J.J.: Open microsurgical autograft of adrenal medulla to the right caudate nucleus in two patients with intractable parkinson’s disease. N. Engl. J. Med. 316: 831–834, 1987.

    Article  PubMed  CAS  Google Scholar 

  8. Madrazo, I., Drucker-Colin, R., Leon, V., Torres, C.: Adrenal medulla transplanted to caudate nucleus for treatment of parkinson’s disease: disease report of 10 cases. Surg. Forum, 38: 510–511, 1987.

    Google Scholar 

  9. Drucker-Colin, R., Madrazo, I., Shkurovich, M., Ostrosky-Solis, F., Torres, C.: Open microsurgical autograft of adrenal medulla to caudate nucleus of patients with parkinson’s disease, in Schmitt Neurological Sciences Symposium, Transplantation into the Mammalian CNS, University of Rochester, Rochester, New York, June 30-July 3, 1987.

    Google Scholar 

  10. Madrazo, I., Leon, V., Torres, C., Aguilera, C., Varela, G., Alvarez, F., Fraga, A., Drucker-Colin, R., Os-trosky, F., Skurovich, M., Franco, R.: Transplantation of fetal substantia nigra and adrenal medulla to the caudate nucleus in two patients with parkinson’s disease. N. Engl. J. Med. 318: 51, 1988.

    PubMed  CAS  Google Scholar 

  11. Allen, G.S., Burns, R.S., Tilipan, N.B.: Human adrenal autografts as apotential therapy for parkinson’s disease, in Schmitt Neurological Sciences Symposium, Transplantation into the Mammalian CNS, University of Rochester, Rochester, New York, June 30-July 3, 1987.

    Google Scholar 

  12. Jiao, S-S., Zhang, W.C., Ding, M.C., Sun, J.B.: The clinical study of adrenal medullary tissue transplantation to striatum in parkinsonism, in Schmitt Neurological Sciences Symposium, Transplantation into the Mammalian CNS, University of Rochester, Rochester, New York, June 30-July 3, 1987.

    Google Scholar 

  13. Brundin, P., Clarke, D.J., Strecker, R.E., Widner, H., Nilsson, O.G., Astedt, B., Lindvall, O., Bjorklund, A.: Experimental basis for clinical trials with dopamine neuron grafting in patients with parkinson’s disease, in Schmitt Neurological Sciences Symposium, Transplantation into the Mammalian CNS. University of Rochester, Rochester, New York, June 30-July 3, 1987.

    Google Scholar 

  14. Bohn, M.C., Cupit, L., Marciano, F., Gash, D.M.: Adrenal medulla grafts enhance recovery of striatal dopaminergic fibers. Science 237: 913–916, 1987.

    Article  PubMed  CAS  Google Scholar 

  15. Morihisa, J.M., Nakamura, R.K., Freed, W.J., Mishkin, M., Wyatt, R.J.: Adrenal medulla grafts survive and exhibit catecholamine-specific fluorescence in the primate brain. Exp. Neurol. 84: 643–653, 1984.

    Article  PubMed  CAS  Google Scholar 

  16. Bankiewicz, K.S., Plunkett, R.J., Oldfield, E.H., Jacobowitz, D.M., Porrino, L.J., Vaidya, U., DiPorzio, U., Schuette, WH., Markowitz, A., London, W.T., Kopin, I.J., in Schmitt Neurological Sciences Symposium, Transplantation into the Mammalian CNS. University of Rochester, Rochester, New York, June 30-July3, 1987.

    Google Scholar 

  17. Fiandaca, M.S., Bakay, R.A.E., Sweeney, K.M., Chan, W.C. (Emory University, Atlanta, Georgia, USA): Immunological response to intracerebral fetal neural allografts in the Rhesus monkey, in Schmitt Neurological Sciences Symposium, Transplantation into the Mammalian CNS, University of Rochester, Rochester, New York, June 30-July 3, 1987.

    Google Scholar 

  18. Lindvall, O., Backlund, E-O., Farde, L., Sedvall, G., Freedman, R., Hoffer, B., Nobin, A., Seiger, A., Olson, L.: Transplantation in parkinson’s disease: two cases of adrenal medullary grafts to the putamen. Ann. of Neurol. 22: 457–468, 1987.

    Article  CAS  Google Scholar 

  19. Dunnett, S.B., Bjorklund, A., Gage, F.H., Stenevi, U.: Transplantation of mesencephalic dopamine neurons to the striatum of adult rats, in Bjorklund A, Stenevi U (Eds): Neural Grafting in the Mammalian CNS, Elsevier Science Publishers, Amsterdam, 1985, pp 451–469.

    Google Scholar 

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© 1988 Plenum Press, New York

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Bakay, R.A.E. (1988). Preliminary Evaluation and Report on Human Adrenal Medullary Grafting. In: Hefti, F., Weiner, W.J. (eds) Progress in Parkinson Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0759-4_23

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  • DOI: https://doi.org/10.1007/978-1-4613-0759-4_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8068-2

  • Online ISBN: 978-1-4613-0759-4

  • eBook Packages: Springer Book Archive

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