New Concepts in the Etiopathogenesis of Systemic Lupus Erythematosus

  • Jean-Paul Viard
  • Laurent Jacob
  • Jean-François Bach


Systemic lupus erythematosus (SLE) is an autoimmune disease characterized clinically by multiple organ involvement and biologically by the production of a wide spectrum of autoantibodies directed against different cell types and cellular antigens, notably nuclear antigens. Polyclonal B cell hyperactivation is considered as the immunological cornerstone of the disease, both in humans and animal models (1).


Systemic Lupus Erythematosus Systemic Lupus Erythematosus Patient Lupus Nephritis Cyproterone Acetate Total Lymphoid Irradiation 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Jean-Paul Viard
    • 1
  • Laurent Jacob
    • 1
  • Jean-François Bach
    • 1
  1. 1.Hôpital NeckerINSERM U 25Paris Cedex 15France

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