Isotope Dilution — Mass Spectrometry as a Reference Method
The accuracy of clinical chemical testing is today evaluated by means of both internal and external quality control using appropriate control sera. For each analyte in a control material more than one analytical method exists and, unfortunately, the results of various methods and of various test kits applied to one and the same control material differ to a greater or lesser extent. This situation is particularly untenable considering the fact that only one value e.g. creatinine concentration in serum can be the “true” one. It is obvious that any progress towards improving the comparability of analytical results from different laboratories is hampered as long as methods with a known or unknown bias are accepted.
KeywordsCholesterol Glycerol Corn Creatinine Cortisol
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