The Clinical Enzymology of the Complement System

  • Michael Loos
  • Jochem Alsenz

Abstract

The complement (C) system is one of the most important humoral systems mediating many activities that contribute to inflammation and host defense, e.g. various anaphylatoxin activities, Chemotaxis and opsonization for phagocytosis. The C system is similar to other humoral systems, such as coagulation, fibrinolysis and the kinin system, a multifactoral system whose activation represents sequentially occurring multi-step activation cascades of the “classical” as well as the “alternative” pathway.

Keywords

Heparin Polysaccharide Arginine Histamine Trypsin 

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References

  1. 1.
    Cooper NR. The classical complement pathway: Activation and regulation of the first complement component. Adv Immunol 1985; in press.Google Scholar
  2. 2.
    Fothergill JE, Anderson WHK. A molecular approach to the complement system. Curr Top cell Regul 1980; 13: 259–311.Google Scholar
  3. 3.
    Müller-Eberhard HJ. Complement. A Rev Biochem 1975; 44: 697–724.CrossRefGoogle Scholar
  4. 4.
    Müller-Eberhard HJ, Schreiber RD. Molecular biology and chemistry of the alternative pathway of complement. Adv Immunol 1980; 29: 1–53.CrossRefGoogle Scholar
  5. 5.
    Müller-Eberhard HJ. Chemistry and function of the complement system. In: Dixon FJ, Fisher DW, eds. The Biology of immunologic disease. Sinauer Associates, Inc., Sunderland, MA, USA 1983.Google Scholar
  6. 6.
    Porter RR, Reid KBM. Activation of the complement system by antibody-antigen complexes: the classical pathway. Adv Protein Chem 1979; 33: 1–71.CrossRefGoogle Scholar
  7. 7.
    Ross GD. Immunobiology of the complement system. Academic press, Inc. 1986.Google Scholar
  8. 8.
    Loos M. The classical complement pathway: Mechanism of activation of the first component by antigen-antibody complexes. Prog Allergy 1982a; 30: 135–192.Google Scholar
  9. 9.
    Loos M. Antibody-independent activation of CI, the first component of complement. Ann Immunol Paris 1982b; 133C: 165–179.CrossRefGoogle Scholar
  10. 10.
    Loos M, Heinz HP. Generation of the classical pathway C3 convertase (EAC4b2a) by proteolytic enzymes. Acta path microbiol Immunol scand Sect C 1984; Suppl 284, 92: 67–74.Google Scholar
  11. 11.
    Pangburn MK, Müller-Eberhard HJ. The alternative pathway of complement. Springer Semin Immunopathol 1984; 7: 163–192.CrossRefGoogle Scholar
  12. 12.
    Müller-Eberhard HJ. The membrane attack complex. Springer Semin Immunopath 1984; 7: 193–219.CrossRefGoogle Scholar
  13. 13.
    Hugli TE. Structure and Function of the anaphylatoxins. Springer Semin Immunopath 1984; 7: 193–219.CrossRefGoogle Scholar
  14. 14.
    Schreiber RD. The chemistry and biology of complement receptors. Springer Semin Immunopath 1984; 7: 221–249.CrossRefGoogle Scholar
  15. 15.
    Fries III LF, Frank MM. Molecular mechanisms of complement action. In: Stamatoyannopoulos G, Nienhuis AW, Leder P, Majerus PW, eds. The molecular basis of blood diseases. Saunders Company 1987.Google Scholar
  16. 16.
    Schapira M, De Agostini A, Schifferli JA, Coiman RW. Biochemistry and pathophysiology of human C1 inhibitor: current issues. Complement 1986; 2: 111–126.Google Scholar
  17. 17.
    Cullmann W, Opferkuch W. C1 inhibitor in Progress Allergy. In: Rother K, Rother U, Karger AC, eds. Heriditary and acquired complement deficiencies in animals and man. 1986; 39: 311.Google Scholar
  18. 18.
    Alsenz J, Bork K, Loos M. Autoantibody-mediated deficiency of C1 inhibitor. N Engl J Med 1987; 316: 1360–1366.CrossRefGoogle Scholar
  19. 19.
    Jackson J, Sim RB, Whelan A, Feighery C. An IgG autoantibody which inactivates C1 inhibitor. Nature 1986; 323: 722–724.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Michael Loos
    • 1
  • Jochem Alsenz
    • 1
  1. 1.Institute of Medical MicrobiologyJohannes Gutenberg UniversityMainzGermany

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