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Metabolism and Enzymology of Nucleic Acids pp 19–25Cite as

The Nature of Distribution of Ribonucleotide Reductases

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Abstract

Ribonucleotide reductases catalyze the irreversible reduction of the 2’-hydroxyl group of ribonucleoside 5’-phosphates to the corresponding 2’-deoxyribonucleoside 5’-phosphates. This reaction is a prerequisite for DNA replication and thus controls the S phase of a cell cycle and cell proliferation. It seems reasonable that all prokaryotic and eukaryotic organisms utilize the same pathway for DNA precursor biosynthesis. It is still not known, however, how many different enzyme systems occur in the different phyla, and the exact mechanism of ribonucleotide reduction is not yet understood.

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Author information

Authors and Affiliations

  1. Fachbereich Chemie der, Philipps-Universität, D-3550, Marburg, Germany

    H. Follmann & J. Harder

  2. Department of Biochemistry, University of Minnesota, Minneapolis, Minnesota, 55455, USA

    H. P. C. Hogenkamp

Authors
  1. H. Follmann
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  2. J. Harder
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  3. H. P. C. Hogenkamp
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Editor information

Editors and Affiliations

  1. Slovak Academy of Sciences, Bratislava, Czechoslovakia

    Ján Zelinka  & Jozef Balan  & 

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© 1988 Plenum Press, New York

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Follmann, H., Harder, J., Hogenkamp, H.P.C. (1988). The Nature of Distribution of Ribonucleotide Reductases. In: Zelinka, J., Balan, J. (eds) Metabolism and Enzymology of Nucleic Acids. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0749-5_3

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  • DOI: https://doi.org/10.1007/978-1-4613-0749-5_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8063-7

  • Online ISBN: 978-1-4613-0749-5

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