Role of Apolipoprotein A IV in the Interconversion of HDL Subclasses

  • P. Gambert
  • L. Lagrost
  • A. Athias
  • S. Bastiras
  • C. Lallemant
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 243)

Abstract

Apolipoprotein A-IV (apo A-IV) is a protein of molecular weight 46 000, present in lymph and plasma chylomicrons, very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in various species including man (1, 2) and is presently considered as a real apolipoprotein. However, unlike most apolipoproteins, apo A-IV has a low affinity for plasma lipoproteins (3-5). It is a relatively hydrophilic protein with the weakest lipid affinity of any human apolipoprotein (6). It is marginally stable in aqueous solution compared to other apolipoproteins and its lipid binding properties are highly sensitive to the environment (5). It presents high self-association tendancies, mainly as dimer associations. All these special properties could be explained by the structural characteristics of the molecule which presents an association of a highly alpha-helical structure (35-54%) (5, 7) and a strongly hydrophobic domain.

Keywords

Cholesterol Lipase Hydrocarbon Phenyl Electrophoresis 

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • P. Gambert
    • 1
  • L. Lagrost
    • 1
  • A. Athias
    • 1
  • S. Bastiras
    • 1
  • C. Lallemant
    • 1
  1. 1.Laboratoire de Biochimie des LipoproteinsFaculté de Médecine Hopital du Bocage - CHRU DijonFrance

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