Contrasting Effects of Selenium and Vitamin E Deficiency on the Anti-Malarial Action of Qinghaosu in Mice

  • O. A. Levander
  • A. L. Ager
  • V. C. Morris
  • R. May

Abstract

The herb Artemisia annua (also known as sweet wormwood) has been used for many centuries in Chinese traditional medicine as a treatment for malaria and fever (1). In 1971, Chinese chemists isolated from the leafy portions of the plant the substance responsible for its reputed medicinal action. This substance, called qinghaosu (QHS) is an endoperoxide of a sesquiterpenoid lactone. It occurred to us, therefore, that the therapeutic efficacy of QHS might be influenced by the antioxidant status of the malarial host. For that reason, we decided to investigate the effect of dietary selenium and vitamin E deficiency on the suppressive and curative efficacy of QHS in a murine model of malaria.

Keywords

Sucrose Corn Citrate Selenium Malaria 

References

  1. 1.
    Klayman, D.L. (1985) Qinghaosu (Artemisinin): an antimalarial drug from China. Science 228: 1049–1055.PubMedCrossRefGoogle Scholar
  2. 2.
    Clark, I.A., Hunt, N.H., and Cowden, W.B. (1986) Oxygen-derived free radicals in the pathogenesis of parasitic disease. Adv. Parasitology 25: 1–44.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • O. A. Levander
    • 1
    • 2
  • A. L. Ager
    • 1
    • 2
  • V. C. Morris
    • 1
    • 2
  • R. May
    • 1
    • 2
  1. 1.USDA Human Nutrition Research CenterBeltsvilleUSA
  2. 2.Center for Tropical Parasitic DiseasesUniversity of MiamiMiamiUSA

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