Trace Elements, Free Radicals and Lipoperoxidation in Rats
Previous studies from this laboratory have demonstrated increased levels of malondialdehyde (MDA) in livers from adult and fetal rats rendered zinc deficient or receiving alcohol during pregnancy — with evidence of potentiated lipoperoxidation when the treatments occurred concurrently (1). Also relevant was the finding (2) that hepatic superoxide dismutase increased in both tissues following gestational alcoholism, which suggested a measure of alcohol metabolism in fetal rat livers, and pointed to the involvement of superoxide-related lipoperoxidation in the raised MDA levels reported earlier. Substantial evidence exists for the generation of superoxide during the metabolism of alcohol via the microsomal ethanol oxidising system, and a protective role for zinc has been proposed which relates to a diminution of the iron-catalysed Haber-Weiss conversion of superoxide into highly reactive hydroxyl radicals.
KeywordsZinc Hydroxyl Manganese Glutathione Superoxide