Trace Elements, Free Radicals and Lipoperoxidation in Rats

  • Ivor E. Dreosti
  • Eric J. Partick


Previous studies from this laboratory have demonstrated increased levels of malondialdehyde (MDA) in livers from adult and fetal rats rendered zinc deficient or receiving alcohol during pregnancy — with evidence of potentiated lipoperoxidation when the treatments occurred concurrently (1). Also relevant was the finding (2) that hepatic superoxide dismutase increased in both tissues following gestational alcoholism, which suggested a measure of alcohol metabolism in fetal rat livers, and pointed to the involvement of superoxide-related lipoperoxidation in the raised MDA levels reported earlier. Substantial evidence exists for the generation of superoxide during the metabolism of alcohol via the microsomal ethanol oxidising system, and a protective role for zinc has been proposed which relates to a diminution of the iron-catalysed Haber-Weiss conversion of superoxide into highly reactive hydroxyl radicals.


Zinc Hydroxyl Manganese Glutathione Superoxide 


  1. 1.
    I.E. Dreosti, I.R. Record and S.J. Manuel, 1985, Zinc and the embryo: A review, Biol. Trace Element Res., 7: 103.CrossRefGoogle Scholar
  2. 2.
    I.E. Dreosti, S.J. Manuel and I.R. Record, 1982, Superoxide dismutase, manganese and the effect of ethanol in adult and fetal rats. Br. J. Nutr. 48: 205.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Ivor E. Dreosti
    • 1
  • Eric J. Partick
    • 1
  1. 1.Division of Human NutritionCSIROAdelaideAustralia

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