Abstract
During fetal development, the content of Zn-metallothionein (Zn-MT) in liver increases, reaching a maximum at birth1. By either feeding pregnant rats a Zn-deficient diet or treatig them with valproate, Zn-MT content in fetal liver is drastically reduced2. In rat liver cells, at least two isoforms of Zn-MT are present. Therefore, we investigated whether these isoforms are identically affected by changing the total Zn-MT content, or whether they are regulated separately.
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References
J. Vormann and T. Günther, Development of Fetal Mineral and Trace Element Metabolism in Rats with Normal as well as Magnesium-and Zinc-Deficient Diets, Biol. Trace Elem. Res. 9: 37 (1986)
J. Vormann, V. Höllriegl, H. J. Merker, T. Günther, Effect of Valproate on Zinc Metabolism in Fetal and Maternal Rats Fed Normal and Zinc-Deficient Diets, Biol. Trace Elem. Res. 10: 25 (1986)
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© 1988 Plenum Press, New York
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Vormann, J., Günther, T. (1988). Effects of Zn-Deficiency and Valproate on Isometallothioneins in Fetal Rat Liver. In: Hurley, L.S., Keen, C.L., Lönnerdal, B., Rucker, R.B. (eds) Trace Elements in Man and Animals 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0723-5_246
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DOI: https://doi.org/10.1007/978-1-4613-0723-5_246
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8050-7
Online ISBN: 978-1-4613-0723-5
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