Effects of Zn-Deficiency and Valproate on Isometallothioneins in Fetal Rat Liver
During fetal development, the content of Zn-metallothionein (Zn-MT) in liver increases, reaching a maximum at birth1. By either feeding pregnant rats a Zn-deficient diet or treatig them with valproate, Zn-MT content in fetal liver is drastically reduced2. In rat liver cells, at least two isoforms of Zn-MT are present. Therefore, we investigated whether these isoforms are identically affected by changing the total Zn-MT content, or whether they are regulated separately.
KeywordsReverse Phase HPLC Fetal Liver Sodium Valproate Daily Oral Dose Control Fetus