Effects of Zn-Deficiency and Valproate on Isometallothioneins in Fetal Rat Liver

  • Jürgen Vormann
  • Theodor Günther

Abstract

During fetal development, the content of Zn-metallothionein (Zn-MT) in liver increases, reaching a maximum at birth1. By either feeding pregnant rats a Zn-deficient diet or treatig them with valproate, Zn-MT content in fetal liver is drastically reduced2. In rat liver cells, at least two isoforms of Zn-MT are present. Therefore, we investigated whether these isoforms are identically affected by changing the total Zn-MT content, or whether they are regulated separately.

Keywords

Zinc HPLC Acetonitrile Spectrophotometry Valproate 

References

  1. 1.
    J. Vormann and T. Günther, Development of Fetal Mineral and Trace Element Metabolism in Rats with Normal as well as Magnesium-and Zinc-Deficient Diets, Biol. Trace Elem. Res. 9: 37 (1986)CrossRefGoogle Scholar
  2. 2.
    J. Vormann, V. Höllriegl, H. J. Merker, T. Günther, Effect of Valproate on Zinc Metabolism in Fetal and Maternal Rats Fed Normal and Zinc-Deficient Diets, Biol. Trace Elem. Res. 10: 25 (1986)CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Jürgen Vormann
    • 1
  • Theodor Günther
    • 1
  1. 1.Institute of Molecular Biology and BiochemistryFree University of BerlinBerlin 33Germany

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