Effects of Zn-Deficiency and Valproate on Isometallothioneins in Fetal Rat Liver

  • Jürgen Vormann
  • Theodor Günther


During fetal development, the content of Zn-metallothionein (Zn-MT) in liver increases, reaching a maximum at birth1. By either feeding pregnant rats a Zn-deficient diet or treatig them with valproate, Zn-MT content in fetal liver is drastically reduced2. In rat liver cells, at least two isoforms of Zn-MT are present. Therefore, we investigated whether these isoforms are identically affected by changing the total Zn-MT content, or whether they are regulated separately.


Reverse Phase HPLC Fetal Liver Sodium Valproate Daily Oral Dose Control Fetus 
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  1. 1.
    J. Vormann and T. Günther, Development of Fetal Mineral and Trace Element Metabolism in Rats with Normal as well as Magnesium-and Zinc-Deficient Diets, Biol. Trace Elem. Res. 9: 37 (1986)CrossRefGoogle Scholar
  2. 2.
    J. Vormann, V. Höllriegl, H. J. Merker, T. Günther, Effect of Valproate on Zinc Metabolism in Fetal and Maternal Rats Fed Normal and Zinc-Deficient Diets, Biol. Trace Elem. Res. 10: 25 (1986)CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Jürgen Vormann
    • 1
  • Theodor Günther
    • 1
  1. 1.Institute of Molecular Biology and BiochemistryFree University of BerlinBerlin 33Germany

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