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Pyridoxal Isonicotinoyl Hydrazone (PIH) and Its Analogues: A New Group of Effective Chelators

  • P. Ponka
  • H. M. Schulman
  • J. Edward

Abstract

Iron, which is involved in many metabolic processes including transport and storage of oxygen and oxidation-reduction reactions is an essential element for all living cells with the one possible exception lactic acid bacilli. However, organisms are not equipped with active excretory systems for iron and, therefore, if excessive amounts of iron get to the organism they accumulate without being excreted. This results in an iron overload which is a common finding in patients with refractory anemias such as thalassemia major, some other hemoglobinopathies and certain other anemias1 – 4. The overload is a consequence of increased iron absorption, but primarily of long-term transfusion therapy. Excess iron accumulates in liver, heart and endocrine glands causing serious dysfunction and death. Excess iron is removed from such patients by administration of chelating agents, primarily desferrioxamine. However, since desferrioxamine is inadequate and expensive, new iron chelating agents are needed5.

Keywords

Iron Overload Aromatic Aldehyde Refractory Anemia Excess Iron Thalassemia Major 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • P. Ponka
    • 1
    • 2
  • H. M. Schulman
    • 1
  • J. Edward
    • 3
  1. 1.Lady Davis Institute for Medical ResearchJewish General HospitalMontrealCanada
  2. 2.Departments of PhysiologyMcGill UniversityMontrealCanada
  3. 3.Departments of ChemistryMcGill UniversityMontrealCanada

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