Nickel Absorption and Elimination in Human Volunteers

  • F. William SundermanJr.
  • Sidney M. Hopfer
  • Thomas Swift
  • Linda Ziebka
  • Allan H. Marcus
  • Bernard M. Most
  • John Creason

Abstract

This study was performed to confirm and extend the observations of Solomons et al. (1982) concerning the inhibitory effect of food on intestinal absorption of nickel in human volunteers. The protocol included (a) stringent precautions against nickel contaminination, (b) quantitation of nickel elimination in feces, and (c) analyses of nickel in body fluids and excreta by sensitive and specific techniques of electrothermal atomic absorption spectrometry.

Keywords

Nickel Polyethylene Syringe Polypropylene Dermatitis 

References

  1. Foulkes, E.C., and McMullen, D.M., 1986, Toxicology, 38: 35.PubMedCrossRefGoogle Scholar
  2. Solomons, N.W., Viteri, F., Shuler, T.R., and Nielsen, F.H., 1982, J. Nutr., 112: 39.PubMedGoogle Scholar
  3. Sunderman, F.W., Jr., Crisostomo, M.C., Reid, M.C., Hopfer, S.M., and Nomoto, S., 1984, Ann, Clin. Lab. Sci., 14: 232.Google Scholar
  4. Sunderman, F.W., Jr., Hopfer, S.M., Crisostomo, M.C., and toeppler, M., 1986a, Ann. Clin. Lab. Sci., 16: 219.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • F. William SundermanJr.
    • 1
  • Sidney M. Hopfer
    • 1
  • Thomas Swift
    • 1
  • Linda Ziebka
    • 1
  • Allan H. Marcus
    • 2
  • Bernard M. Most
    • 3
  • John Creason
    • 2
  1. 1.University of Connecticut School of MedicineFarmingtonUSA
  2. 2.U.S. Environmental Protection AgencyResearch Triangle ParkUSA
  3. 3.Northrup Services, Inc.Research Triangle ParkUSA

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