Pancreatic Superoxide Dismutase Activity in the Copper-Depleted Rat
Since Cu deficiency in rats is accompanied by progressive atrophy of pancreatic tissue (2, 6–8), this study was designed to investigate the role of the Cu-dependent enzymes superoxide dismutase (CuSOD) and cytochrome oxidase and the Mn-dependent enzyme superoxide dismutase (MnSOD) in this process. Superoxide dismutase catalyzes the dismutation of the superoxide radical anion (O2 −) to O and H2O2 and is considered to have an important role in protecting cells against direct and indirect oxidative damage (4, 5). The cytotoxicity of O2 − has been ascribed to the secondary production of highly reactive intermediates, such as hydroxy radicals (4).
KeywordsCytochrome Oxidase Amylase Activity Packed Cell Volume Secondary Production MnSOD Activity
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