Pancreatic Superoxide Dismutase Activity in the Copper-Depleted Rat

  • A. Mylroie
  • A. Boseman
  • J. Kyle

Abstract

Since Cu deficiency in rats is accompanied by progressive atrophy of pancreatic tissue (2, 6–8), this study was designed to investigate the role of the Cu-dependent enzymes superoxide dismutase (CuSOD) and cytochrome oxidase and the Mn-dependent enzyme superoxide dismutase (MnSOD) in this process. Superoxide dismutase catalyzes the dismutation of the superoxide radical anion (O2 ) to O and H2O2 and is considered to have an important role in protecting cells against direct and indirect oxidative damage (4, 5). The cytotoxicity of O2 has been ascribed to the secondary production of highly reactive intermediates, such as hydroxy radicals (4).

Keywords

Toxicity H2O2 Superoxide Amylase Triethylene 

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • A. Mylroie
    • 1
  • A. Boseman
    • 1
  • J. Kyle
    • 1
  1. 1.Department of Physical SciencesChicago State UniversityChicagoUSA

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