Pancreatic Superoxide Dismutase Activity in the Copper-Depleted Rat

  • A. Mylroie
  • A. Boseman
  • J. Kyle


Since Cu deficiency in rats is accompanied by progressive atrophy of pancreatic tissue (2, 6–8), this study was designed to investigate the role of the Cu-dependent enzymes superoxide dismutase (CuSOD) and cytochrome oxidase and the Mn-dependent enzyme superoxide dismutase (MnSOD) in this process. Superoxide dismutase catalyzes the dismutation of the superoxide radical anion (O2 ) to O and H2O2 and is considered to have an important role in protecting cells against direct and indirect oxidative damage (4, 5). The cytotoxicity of O2 has been ascribed to the secondary production of highly reactive intermediates, such as hydroxy radicals (4).


Cytochrome Oxidase Amylase Activity Packed Cell Volume Secondary Production MnSOD Activity 
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  1. 1.
    American Institute of Nutrition. 1977. Ad hoc committee on standards for nutritional studies. J. Nutr. 107: 1340–1348.Google Scholar
  2. 2.
    Fell, B.F., King, T.P. and N.T. Davies. 1982. Pancreatic atrophy in copper-deficient rats: histochemical and ultrastructural evidence of a selective effect on acinar cells. Histochem. J. 14: 665–680.PubMedCrossRefGoogle Scholar
  3. 3.
    Forman, H.J. and A. Boveris. 1982. Superoxide Radical and Hydrogen Peroxide in Mitochondria. In: Free Radicals in Biology V. Academic Press New York pp 65–90.Google Scholar
  4. 4.
    Fridovich, I. 1981. Role and Toxicity of Superoxide in Cellular Systems. In: Oxygen and Oxy-Radicals in Chemistry and Biology. Academic Press New York.Google Scholar
  5. 5.
    Halliwell, B. 1978. Biochemical mechanisms accounting for the toxic action of oxygen on living organisms: The Key Role of Superoxide Dismutase. In: Cell Biol. Int. Reports 2: 113–128.Google Scholar
  6. 6.
    Muller, H.B. 1970. Der einfluss kupferarmer kost an das pancreas. Virchows Arch. Abt. A Path. Anat 350: 353–367.CrossRefGoogle Scholar
  7. 7.
    Mylroie, A.A., Tucker, C., Umbles, C. and J. Kyle. 1987. In: Trace Substances in Environmental Health, Hemphill, D.D. ed., University of Missouri, Missouri. In press.Google Scholar
  8. 8.
    Smith, P.A., Sunter, J.P. and R.M. Case. 1982. Progressive atrophy of pancreatic acinar tissue in rats fed a copper-deficient diet supplemented with D-Penicillamine or triethylene tetramine: morphological and physiological studies. Digestion 23: 16–30.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • A. Mylroie
    • 1
  • A. Boseman
    • 1
  • J. Kyle
    • 1
  1. 1.Department of Physical SciencesChicago State UniversityChicagoUSA

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