Influence of Glutathione Depletion on Hepatic Copper Uptake and Biliary Copper Excretion in the Rat

  • H. Nederbragt


Although it was demonstrated1 that glutathione (GSH) depletion reduced biliary copper (Cu) excretion in rats, the relation between GSH and Cu excretion has not been fully investigated. The purpose of this study was to contribute to the understanding of the process of biliary Cu excretion and the role of GSH in it.


Bile Duct Time Control Biliary Excretion Bile Sample Glutathione Depletion 
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  1. 1.
    J.Alexander and J.Aaseth, Biliary excretion of copper and zinc in the rat as influenced by diethylmaleate, selenite and diethyldithiocarbamate, Biochem.Pharmaco1. 29: 2129 (1980).CrossRefGoogle Scholar
  2. 2.
    H.Nederbragt and A.J.Lagerwerf, Strain-related patterns of biliary excretion and hepatic distribution of copper in the rat, Hepatology 6: 601 (1986).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • H. Nederbragt
    • 1
  1. 1.Department of Pathology, Faculty of Veterinary ScienceScience State UniversityUtrechtThe Netherlands

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