Purification and Properties of the Human Plasma Selenoenzyme, Glutathione Peroxidase

  • J. T. Deagen
  • D. J. Broderick
  • P. D. Whanger

Abstract

About 80% of the selenium (Se) present in ovine erythrocytes is associated with glutathione peroxidase (GPx).l In contrast, less than 4% of the Se present in rat plasma was calculated to be present as GPx.2 Consistent with this, evidence has been obtained in our laboratory that the majority of the Se present in human plasma is not associated with GPx.1 Other workers have shown that the antigenicity of human erythrocyte GPx differs from this selenoenzyme in plasma.3 Therefore, the human plasma GPx was purified to determine how its properties may differ from the erythrocyte enzyme.

Keywords

Peroxi Filtration Glutathione Glycine Cysteine 

References

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • J. T. Deagen
    • 1
  • D. J. Broderick
    • 1
  • P. D. Whanger
    • 1
  1. 1.Department of Agricultural ChemistryOregon State UniversityCorvallisUSA

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