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UVB Induced Production of Keratinocyte Derived Suppressor Factors

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Light in Biology and Medicine

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Abstract

Excessive exposure to sunlight is the major etiologic factor in the development of squamous cell carcinomas, basal cell carcinomas and possibly malignant melanomas. Ultraviolet (UV) light mediated carcinogenesis is a complex process which is not completely understood. First, chronic exposure of animals to UV light shows that it acts both as a tumor initiator and promotor upon epidermal cells (EC). Secondly, it may impair the body’s immune response to the altered ECs permitting the survival and growth of neoplastic epidermal cells (1). In particular mice exposed to UV light develop T-suppressor lymphocytes that prevent 1. sensitization to potent contact allergens (2) and 2. immunologic rejection of highly antigenic UV induced skin cancer (3). Immunologic alterations that occur following exposure to UV radiation can be divided into two types: local and systemic immunosuppression.

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Author information

Authors and Affiliations

  1. Departgent of Dermatology, Hospital Vienna-Lainz, Vienna, Austria

    Thomas Schwarz & Fritz Gschnait

  2. Department of Dermatology II, University of Vienna and Ludwig Boltzmann Institute for Dermatovenerologic Serodiagnosis, Laboratory for Cellbiology, Vienna, Austria

    Agatha Urbanski & Thomas A. Luger

Authors
  1. Thomas Schwarz
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  2. Agatha Urbanski
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  3. Fritz Gschnait
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  4. Thomas A. Luger
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Editor information

Editors and Affiliations

  1. The City University, London, UK

    Ron H. Douglas

  2. The Norwegian Radium Hospital, Oslo, Norway

    Johan Moan

  3. University of Padua, Padua, Italy

    F. Dall’Acqua

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© 1988 Plenum Press, New York

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Schwarz, T., Urbanski, A., Gschnait, F., Luger, T.A. (1988). UVB Induced Production of Keratinocyte Derived Suppressor Factors. In: Douglas, R.H., Moan, J., Dall’Acqua, F. (eds) Light in Biology and Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0709-9_39

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  • DOI: https://doi.org/10.1007/978-1-4613-0709-9_39

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8043-9

  • Online ISBN: 978-1-4613-0709-9

  • eBook Packages: Springer Book Archive

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