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Viral Hepatitis

  • Chapter
Viral Infections of Humans

Abstract

The term viral hepatitis denotes those infections caused by agents whose primary tissue tropism is the liver and includes five distinct disease entities caused by at least five viruses. Hepatitis A is an acute self-limited disease caused by infection with hepatitis A virus. Hepatitis B results from infection with hepatitis B virus, and following the acute infection, a proportion of infected individuals becomes persistently infected with the virus, at risk of chronic liver disease and primary liver cancer. The etiologic agent of delta hepatitis is the “incomplete” delta virus, which requires the presence of hepatitis B virus in order to replicate and produce infection. Non-A, Non-B hepatitis is a diagnosis of exclusion, and disease entities have been defined epidemiologically. Infection that results from the currently undefined agent(s) that are parenterally transmitted usually becomes persistent and results in chronic liver disease. The other form of Non-A, Non-B hepatitis results from infection with a newly defined agent, which is transmitted enterically and produces an acute, apparently self-limited, disease.

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Reference

  1. Aach, R. D., Szmuness, W., Mosley, J. W., Hollinger, F. B., Kahn, R. A., Stevens, C. E., Edwards, V. M., and Werch, J., Serum alanine aminotransferase of donors in relation to the risk of Non-A, Non-B hepatitis in recipients: The Transfusion-Transmitted Viruses Study,N. Engl. J. Med. 304: 989 – 994 (1981).

    Article  Google Scholar 

  2. Acute Hepatic Failure Study Group, Etiology and prognosis in fulminant hepatitis,Gastroenterology 77: A33 (1979).

    Google Scholar 

  3. Ahtone, J., Francis, D. P., Bradley, D. W., and Maynard, J. E., Non-A, Non-B hepatitis in a nurse after percutaneous needle exposure,Lancet 1: 1142 (1980).

    Article  Google Scholar 

  4. Alpert, E., Isselbacher, K. J., and Chur, P. H., The pathogenesis of arthritis associated with viral hepatitis. Complement-component studies,N. Engl. J. Med. 35: 185 – 189 (1971).

    Article  Google Scholar 

  5. Alter, H. J., Purcell, R. H., Holland, P. V., Alling, D. W., and Koziol, D. E., Donor transaminase and recipient hepatitis: Impact on blood transfusion services,J.A.M.A. 246: 630 – 634 (1981).

    Article  Google Scholar 

  6. Alter, M. J., Ahtone, J., Weisfuse, I., Starko, K., Vacalis, T. B., andMaynard, J. E., HepatitisB transmission between heterosexuals,J.A.M.A. 256: 1307 – 1310 (1986).

    Article  Google Scholar 

  7. Alter, M. J., Favero, M. S., and Maynard J. E., Impact of infection control strategies on the incidence of dialysis-associated hepatitis in the United States,J. Infect. Dis. 153: 1149 – 1151 (1986).

    Article  Google Scholar 

  8. Alter, M. J., Gerety, R. J., Smallwood, L. A., Sampliner, R. E., Tabor, E., Deinhardt, F., Frosner,, and Matanoski, G. M., Sporadic Non-A, Non-B hepatitis: Frequency and epidemiology in an urban United States population,J. Infect. Dis. 145: 886 – 893 (1982).

    Article  Google Scholar 

  9. Aragona, M., Macaguo, S., Caredda, F., Crivelli, O., Lavarini, C., Bertolusso, L., Farci, P., and Rizzetto, M., IgM anti-HD in acute hepatitis D: Diagnostic and prognostic significance,Prog. Clin. Biol. Res. 234: 243 – 248 (1986).

    Google Scholar 

  10. Arevalo, J. A., and Washington, A. E., Cost effectiveness of prenatal screening and immunization for hepatitis B virus,J.A.M.A. 259: 365 – 369 (1988).

    Article  Google Scholar 

  11. Arico, S., Aragona, M., Rizzetto, M., Caredda, F., Zanetti, A., Marinucci, G., Diana, S., Farci, P., Arnone, M., Caporaso, N., Ascione, A., Dentico, P., Pastore, G., Raimondo, G., and Craxi, A., Clinical significance of antibody to the hepatitis delta virus in symptomless HBsAg carriers,Lancet 2: 356 – 357 (1985).

    Article  Google Scholar 

  12. Balayan, M. S., Andjparidze, A. G., Savinskaya, S. S., Ketiladze, E. S., Braginsky, D. M., Savino, A. P., and Poleschuk, E. F., Evidence for a virus in Non-A, Non-B hepatitis transmitted via the fecal—oral route,Intervirology 20: 23 – 31 (1983).

    Article  Google Scholar 

  13. Bancroft, W. H., Holland, P. H., Mazzur, S., Courouce, A. M., and Madalinski, K., The geographical distribution of HBsAg subtypes,Bibl. Haematol. Basel 42: 42 – 68 (1976).

    Google Scholar 

  14. Bancroft, W. H., Snitbhan, R., Scott, R. M., Tingpalapong, W. T., Watson, W. T., Tauticharoenyos, P., Karwacki, J. J., and Srimarut, S., Transmission of hepatitis B virus to gibbons by exposure to human saliva containing hepatitis B surface antigen,J. Infect Dis. 135: 79 – 85 (1977).

    Article  Google Scholar 

  15. Beasley, R. P., and Huang, L.-Y., Postnatal infectivity in hepatitis B surface antigen carrier mothers,J. Infect. Dis. 147: 185 – 190 (1983).

    Article  Google Scholar 

  16. Beasley, R. P., Huang, L. Y., Stevens, C. E., Lin, C. C., Cahsieh, F. J., Wang, K. Y., Sun, T. S., and Szmuness, W., Efficacy of hepatitis B immune globulin for prevention of perinatal transmission of the hepatitis B carrier state: Final report of a randomized double-blind placebo-controlled trial,Hepatology 3: 135 – 141 (1983).

    Article  Google Scholar 

  17. Beasley, R. P., Trepo, C., Stevens, C. E., and Szmuness, W., The e antigen in vertical transmission of hepatitis B surface antigen,Am. J. Epidemiol. 105: 94 – 98 (1977).

    Google Scholar 

  18. Ben-Porath, E., Wands, J., Gruiam, M., and Isselbacher, K., Clinical significance of an enhanced detection of HBsAg by a monoclonal radioimmunoassay,Hepatology 4: 803 – 807 (1984).

    Article  Google Scholar 

  19. Ben-Porath, E., Wands, J. R., Marciniak, R. A., Wong, A. M., Hornstein, O., Ryder, R., Canlas, M., Lingao, A., and Isselbacher, K. J., Structural analysis of hepatitis B surface antigen by monoclonal antibodies,J. Clin. Invest. 76: 1338 – 1347 (1985).

    Article  Google Scholar 

  20. Bensabath, G., Hadler, S. C., Pereira–Soares, M. C., Fields, H. A., Maynard, J. E., Epidemiologic and serologic studies of viral hepatitis in Brazil’s Amazon Basin,Bull. Pan. Am. Health Org. 21: 16 – 27 (1987).

    Google Scholar 

  21. Berninger, M., Hammer, M., Hoyer, B., and Gerin, J. L., An assay for the detection of DNA genome of hepatitis B virus in serum,J. Med. Virol. 9: 57 – 68 (1982).

    Article  Google Scholar 

  22. Bianchi, L., The immunopathology of acute type B hepatitis,Springer Semin. Immunopathol. 3: 421 – 438 (1981).

    Article  Google Scholar 

  23. Binn, L. N., Bancroft, W. H., Lemon, S. M., Marchwicki, R. H., LeDuc, J. W., Trahan, C. J., Staley, E. C., and Keenan, C. M., Preparation of a prototype inactivated hepatitis A virus vaccine from infected cell cultures,J. Infect. Dis. 153: 749 – 756 (1986).

    Article  Google Scholar 

  24. Blumberg, B. S., Alter, H. J., and Visnich, S., A “new” antigen in leukemia sera,J.A.M.A. 191: 541 – 546 (1965).

    Google Scholar 

  25. Bonino, F., Hoyer, B. H., Shih, J. W.-K., Rizzetto, M., Purcell, R. H., and Gerin, J. L., Delta hepatitis agent: Structural and antigenic properties of the delta associated particle,Infect. Immun. 43: 1000 – 1005 (1984).

    Google Scholar 

  26. Bonino, F., Negro, F., Baldi, M., Brunetto, M. F., Chiaberge, E., Rocca, N., and Rocca, G., The natural history of chronic delta hepatitis,Prog. Clin. Biol. Res. 234: 145 – 152 (1986).

    Google Scholar 

  27. Bonino, F., and Smedile, A., Delta agent (type D) hepatitis,Semin. Liver Dis. 6: 28 – 33 (1986).

    Article  Google Scholar 

  28. Bradley, D. W., Transmission, etiology and pathogenesis of viral hepatitis Non-A, Non-B in non-human primates, in:Advances in Hepatitis Research(F. Chisari, ed.), pp. 268 – 280, Masson, New York, 1984.

    Google Scholar 

  29. Bradley, D. W., Krawczynski, K., Cook, E. H., McCaustland, K. A., Humphrey, C. D., Spelbring, J. E., Myint, H., and Maynard, J. E., Enterically transmitted Non-A, Non-B hepatitis: Serial passage of disease in cynomolgus macaques and tamarins and recovery of disease-associated 27–34-nm viruslike particles,Proc. Natl. Acad. Sci. U.S.A. 84: 6277 – 6281 (1987).

    Article  Google Scholar 

  30. Bradley, D. W., Maynard, J. E., Popper, H., Cook, E. H., Ebert, J. W., McCaustland, K. A., Schable, C. A., and Fields, H. A., Posttransfusion Non-A Non-B hepatitis: Physicochemical properties of two distinct agents,J. Infect. Dis. 148: 254 – 265 (1983).

    Article  Google Scholar 

  31. Buitrago, B., Popper, H., Hadler, S. C., Thung, S. N., Gerber, M. A., Purcell, R. H., and Maynard, J. E., Specific histologic features of Santa Marta hepatitis: A severe form of hepatitis delta virus infection in northern Colombia,Hepatology 6: 1285 – 1291 (1986).

    Article  Google Scholar 

  32. Caredda, F., Antinori, S., Re, T., Pastecchia, C., and Moroni, M., Course and prognosis of acute HDV infection,Prog. Clin. Biol. Res. 234: 267 – 276 (1986).

    Google Scholar 

  33. Carl, M., Blakey, D. L., Francis, D. P., and Maynard, J. E., Interruption of hepatitis B transmission by modification of a gynecologist’s surgical technique,Lancet 1: 731 – 733 (1982).

    Article  Google Scholar 

  34. Carl, M., Francis, D. P., and Maynard, J. E., Food-borne hepatitis A: Recommendations for control,J. Infect. Dis. 148: 1133 – 1135 (1983).

    Article  Google Scholar 

  35. Centers for Disease Control, Viral Hepatitis A:Research Progress and Current Perspectives, CDC, Atlanta, 1983.

    Google Scholar 

  36. Centers for Disease Control, Recommendations for the prevention of viral hepatitis,Morbid. Mortal. Week. Rep 34: 313–324, 329 – 335 (1985).

    Google Scholar 

  37. Centers for Disease Control, Summary of notifiable diseases, United States, 1986,Morbid. Mortal. Week. Rep 35(55): 10, 23–25, 51 – 57 (1986).

    Google Scholar 

  38. Centers for Disease Control, Enterically transmitted Non-A, Non-B hepatitis—East Africa,Morbid. Mortal. Week. Rep. 36: 241 – 244 (1987).

    Google Scholar 

  39. Centers for Disease Control, Enterically transmitted Non-A, Non-B hepatitis—Mexico,Morbid. Mortal. Week. Rep. 36: 597 – 602 (1987).

    Google Scholar 

  40. Centers for Disease Control,Hepatitis Surveillance Report No 51, CDC, Atlanta, 1987.

    Google Scholar 

  41. Chau, K. H., Hargie, M. P., Decker, R. H., Mushahwar, I. K., and Overby, L. R., Serodiagnosis of recent hepatitis B infection by IgM class anti-HBc,Hepatology 3: 142 – 149 (1983).

    Article  Google Scholar 

  42. Chen, D.-S., Lai, M.-Y., Lee, S.-C., Yang, P.-N., Sheu, J.-C., and Sung, J.-L., Serum HBsAg, HBeAg, anti-HBe and hepatitis B viral DNA in asymptomatic carriers in Taiwan,J. Med. Virol. 19: 87 – 94 (1985).

    Article  Google Scholar 

  43. Conrad, M. E., and Lemon, S. M., Prevention of endemic icteric viral hepatitis by administration of immune serum globulin,J. Infect. Dis. 156: 56 – 63 (1987).

    Article  Google Scholar 

  44. Courouce, A. M., Holland, P. V., Muller, J. Y., and Soulier, J. P., HBs antigen subtypes. Proceedings of the international workshop of HBs antigen subtypes,Bibl. Haematol. Basel 42: 1 – 158 (1976).

    Google Scholar 

  45. Coursaget, P., Yvonnet, B., Chotard, J., Sarr, M., Vincelot, T. P., N’doye, R., Diop-Mar, I., and Chiron, J. P., Seven-year study of hepatitis B vaccine efficacy in infants from an endemic area (Senegal),Lancet 2: 1143 – 1145 (1986).

    Article  Google Scholar 

  46. DeCock, K. M., Bradley, D. W., Sandford, N. L., Govindarajan, S., Maynard, J. E., and Redeker, A. J., Epidemic Non-A, Non-B hepatitis in patients from Pakistan,Ann. Intern. Med. 106: 227 – 230 (1987).

    Google Scholar 

  47. Dienstag, J. L., Immunogenesis of the extrahepatic manifestations of hepatitis B virus infection,Springer Semin. Immunopathol. 3: 461 – 472 (1981).

    Article  Google Scholar 

  48. Dienstag, J. L., Non A-non B hepatitis, I. Recognition, epidemiology and clinical features,Gastroenterology 85: 439 – 462 (1983).

    Google Scholar 

  49. Dienstag, J. L., Non-A, Non-B hepatitis. II. Experimental transmission, putative virus agents and markers, and prevention,Gastroenterology 85: 743 – 768 (1983).

    Google Scholar 

  50. Dienstag, J. L., Savarese, A. M., and Bhan, A. K., Increased natural killer cell activity in chronic hepatitis B infection,Hepatology 2(Suppl.): 107 – 115 (1982).

    Google Scholar 

  51. Dienstag, J. L., Szumness, W., Stevens, C. E., and Purcell, R. H., Hepatitis A virus infection: New insights from seroepidemiologic studies,J. Infect. Dis. 137: 328 – 340 (1978).

    Article  Google Scholar 

  52. Dreesman, G. R., Hollinger, F. B., Sanchez, Y., Oefinger, P., and Melnick, J. L., Immunization of chimpanzees with hepatitis B virus-derived polypeptides,Infect. Immun. 32: 62 – 67 (1981).

    Google Scholar 

  53. Editorial, Jaundice following yellow fever vaccination,J.A.M.A. 119:110(1942).

    Google Scholar 

  54. Eichberg, J. W., and Kalter, S. S., Hepatitis A and B: Serologic survey of human and non-human primate sera,Lab. Animal Sci. 30: 541 – 543 (1980).

    Google Scholar 

  55. Farci, P., Gerin, J. L., Aragona, M., Lindsey, I., Crivelli, O., Balestrieri, A., Smedile, A., Thomas, H. C., and Rizzetto, M., Diagnostic and prognostic significance of the IgM antibody to the hepatitis delta virus,J.A.M.A. 255: 1443 – 1446 (1986).

    Article  Google Scholar 

  56. Fawaz, K. A., and Matioff, D. S., Viral hepatitis in homosexual men,Gastroenterology 81: 537 – 538 (1981).

    Google Scholar 

  57. Fay, O. H., Hadler, S. C., Maynard, J. E., and Pinheiro, F., Hepatitis in the Americas,Bull. Pan Am. Health Org. 19: 401 – 408 (1985).

    Google Scholar 

  58. Feinstone, S. M., Kapikian, A. Z., and Purcell, R. H., Hepatitis A: Detection by immune electron microscopy of a virus-like antigen associated with acute illness,Science 182: 1026 – 1028 (1973).

    Article  Google Scholar 

  59. Fields, H. A., Bradley, D. W., Davis, C. L., Murphy, B. L., Schable, C. A., and Maynard, J. E., Radioimmunoassay for the detection of hepatitis e antigen (HBeAg) and antibody (anti-HBe),J. Immunol. 121: 930 – 935 (1978).

    Google Scholar 

  60. Fields, H. A., and Hadler, S. C., Delta hepatitis: A review,J. Clin. Immunoassay 9: 128 – 142 (1986).

    Google Scholar 

  61. Findlay, G. M., and MacCallum, F. O., Note on acute hepatitis and yellow fever immunization,Trans. R. Soc. Trop. Med. Hyg. 31: 297 – 308 (1937).

    Article  Google Scholar 

  62. Fletcher, M. L., Trowell, J. M., Craske, J., Pavier, K., and Rizza, C. R., Non-A, Non-B hepatitis after transfusion of factor VIII in infrequently treated patients,Br. Med. J. 287: 1754 – 1757 (1983).

    Article  Google Scholar 

  63. Francis, D. P., Hadler, S. C., Prendergast, T. J., Peterson, E., Ginsberg, M. M., Lookabaugh, C., Holmes, J. R., and Maynard, J. E., Occurance of hepatitis A, B, and Non-A, Non-B in the United States: CDC Sentinel County Study I,Am. J. Med. 76: 69 – 74 (1984).

    Article  Google Scholar 

  64. Francis, D. P., Hadler, S. C., Thompson, S. E., Maynard, J. E., Ostrow, D. G., Altman, N., Braff, E. H., O’Malley, P. M., Hawkins, D., Judson, F. N., Penley, K., Nylund, T., Christie, G., Meyers, F., Moore, J. N., Gardner, A., Doto, I. L., Miller, J. H., Reynolds, G. H., Murphy, B. L., Schable, C. A., Clark, B. T., Curran, J. W., and Redeker, A. G., Prevention of hepatitis B with vaccine. Report from the Centers for Disease Control multi-center efficacy trial among homosexual men,Ann. Intern. Med. 97: 362 – 366 (1982).

    Google Scholar 

  65. Frosner, G. G., Papavangelou, G., Butler, R., Iwarson, S., Lindholm, A., Courouce-Pauty, A., Haas, H., and Deinhardt, F., Antibody against hepatitis A in seven European countries,Am. J. Epidemiol. 110: 63 – 69 (1979).

    Google Scholar 

  66. Galbraith, R. M., Dienstag, J. L., Purcell, R. H., Gower, R. H., Zuckerman, A. J., and Williams, R., Non-A, Non-B hepatitis associated with chronic liver disease in a hemodialysis unit,Lancet 1: 951 – 953 (1979).

    Article  Google Scholar 

  67. Gerber, M. A., and Thung, S. N., Pathobiology of hepatitis B virus,Pathobiol. Ann. 11: 197 – 228 (1981).

    Google Scholar 

  68. Govindarajan, S., Kanel, G. C., and Peters, R. C., Prevalence of delta antibody among chronic hepatitis B virus infected patients in the Los Angeles area: Its correlation with liver biopsy diagnosis,Gastroenterology 85: 160 – 166 (1983).

    Google Scholar 

  69. Gust, I. D., Lehmann, N. I., and Lucas, C. R., Relationship between prevalence of antibody to hepatitis A antigen and age: A cohort effect?J. Infect. Dis. 138:425–426 (1978).

    Article  Google Scholar 

  70. Guyer, B., Bradley, D. W., Bryan, J. A., Maynard, J. E., Non-A, Non-B hepatitis among participants in a plasmapheresis stimulation program,J. Infect. Dis. 139:634–640 (1979).

    Article  Google Scholar 

  71. Hadler, S. C., De Monson, M., Ponzetto, A., Anzola, E., Rivero, D., Mondolfi, A., Bracho, A., Francis, D. P., Gerber, M. A., Thung, S., Gerin, J. L., Maynard, J. E., Popper, H., and Purcell, R. H., Delta virus infection and severe hepatitis. An epidemic in the Yucpa Indians of Venezuela,Ann. Intern. Med. 100: 339 – 344 (1984).

    Google Scholar 

  72. Hadler, S. C., Doto, I. L., Maynard, J. E., Smith, J., Clark, B., Mosley, J., Eickhoff, T., Himmelsbach, C. K., and Cole, W. R., Occupational risk of hepatitis B infection in hospital workers,Infect. Control 6: 24 – 31 (1985).

    Google Scholar 

  73. Hadler, S. C., Francis, D. P., Maynard, J. E., Thompson, S. E., Judson, F. N., Elchenberg, D. F., Ostrow, D. G., O’Malley, P. M., Penley, K. A., Altman, N. L., Braff, E. F., Shipmann, G., Coleman, P. J., and Mandel, E. J., Long-term immunogenicity and efficacy of hepatitis B vaccine in homosexual men,N. Engl. J. Med. 215: 209 – 214 (1986).

    Article  Google Scholar 

  74. Hadler, S. C., and McFarland, L., Hepatitis in day care centers: Epidemiology and prevention,Rev. Infect. Dis. 8: 548 – 557 (1985).

    Article  Google Scholar 

  75. Hadler, S. C., Murphy, B. L., Schable, C. A., Heyward, W. L., Francis, D. P., and Kane, M. A., Epidemiological analysis of the significance of low positive test results on antibody to hepatitis B and core antigens,J. Clin. Microbiol. 19: 521 – 525 (1984).

    Google Scholar 

  76. Hadler, S. C., Rivero, D., Monzon, M. A., and Perez, M., Ongoing studies of delta infection in the Yucpa Indians in Venezuela,J. Med. Virol 21(4):33A (1987).

    Google Scholar 

  77. Hadler, S. C., Sorley, D. L., Acree, K. H., Webster, H. M., Schable, C. A., Francis, D. P., and Maynard, J. E., An outbreak of hepatitis B in a dental practice,Ann. Intern. Med. 95: 133 – 138 (1981).

    Google Scholar 

  78. Halsey, N. A., Reppert, E. J., Margolis, H. S., Francis, D. P., and Fields, H. A., Intradermal hepatitis B vaccination in an abbreviated schedule,Vaccine 4: 228 – 232 (1986).

    Article  Google Scholar 

  79. Hansson, B. G., Moestrup, T., Widell, A., and Nordenfelt, A., Infection with delta agent in Sweden: Introduction of a new hepatitis agent,J. Infect. Dis. 142: 472 – 478 (1982).

    Article  Google Scholar 

  80. Heathcote, J., Cameron, C. H., and Dane, B. S., Hepatitis B antigen in saliva and semen,Lancet 1: 71 – 73 (1974).

    Article  Google Scholar 

  81. Heijtink, R. A., Van Hattum, J., Schalm, S. W., and Masurel, N., J. Med. Virol. 10:83–90(1982).

    Article  Google Scholar 

  82. Heyward, W. L., Bender, T. R., McMahon, B. J., Hall, D. B., Francis, D. P., Lanier, A. P., Alward, W. L. M., Ahtone, J. L., Murphy, B. L., and Maynard, J. E., The control of hepatitis B virus infection with vaccine in Yupik Eskimos. Demonstration of safety, immunogenicity, and efficacy under field conditions,Am. J. Epidemiol 121:914– 923 (1985).

    Google Scholar 

  83. Heyward, W. L., Lanier, A. P., McMahon, B. J., Fitzgerald, M. A., Killkenny, S., and Paprocki, T. R., Early detection of primary hepatocellular carcinoma. Screening for primary hepatocellular carcinoma among persons infected with hepatitis B virus,J.A.M.A. 254: 3052 – 3054 (1985).

    Article  Google Scholar 

  84. Hollinger, F. B., and Dienstag, J. L., Hepatitis viruses, in:Manual of Clinical Microbiology, 4th ed. (E. H. Lennette, A. Balows, W. H. Hausler, Jr., and H. J. Shadomy, eds.), pp. 813 – 835, American Society of Microbiology, Washington, 1985.

    Google Scholar 

  85. Hollinger, F. B., Dreesman, G. R., Sparrow, J., and Melnick, J. L., Synthetic peptide vaccine for hepatitis B,Dev. Biol. Stand. 54: 113 – 116 (1983).

    Google Scholar 

  86. Hollinger, F. B., Mosley, J. W., Szmuness, W., Aach, R. D., Peters, R. L., and Stevens, C., Transfusion Transmitted Viruses Study: Experimental evidence for two Non-A Non-B hepatitis agents,J. Infect. Dis. 142: 400 – 407 (1980).

    Article  Google Scholar 

  87. Hoofnagle, J. H., Mullen, K. D., Jones, B., Rustgi, V., Bisceglie, A. D., Peters, M., Waggoner, J. G., Park, Y., and Jones, E. A., Treatment of chronic Non-A, Non-B hepatitis with recombinant human alpha interferon: A preliminary report,N. Engl. J. Med. 315: 1575 – 1578 (1986).

    Article  Google Scholar 

  88. Ikematsu, H., Kashigawi, S., Hayashi, J., Nomura, H., Kajiyama, W., Tani, S., Uragari, Y., and Goto, M., A seroepidemiological study of hepatitis A virus infections: Statistical analysis of two independent cross-sectional surveys in Okinawa, Japan,Am. J. Epidemiol. 126: 50 – 54 (1987).

    Google Scholar 

  89. Inman, R. D., McDougal, J. S., Redecha, P. B., Lockshin, M. D., Stevens, C. E., and Christian, C. L., Isolation and characterization of circulating immune complexes in patients with hepatitis B systemic vasculitis,Clin. Immunol. Immunopathol. 21: 364 – 374 (1981).

    Article  Google Scholar 

  90. Institute of Medicine,New Vaccine Development—Establishing Priorities, Vol. II, Diseases of Importance in Developing Countries, pp. 197–222, National Academy Press, Washington, 1986.

    Google Scholar 

  91. Jenison, S. A., Lemon, S. M., Baker, L. N., and Newbold, J. E., Quantitative analysis of hepatitis B virus DNA in saliva and semen of chronically infected homosexual men,J. Infect. Dis. 156: 299 – 307 (1987).

    Article  Google Scholar 

  92. Jonas, M. A., Schiff, E. R., O’Sullivan, M. J., Medina, M. D., Ruddy, K. R., Jeffers, L. J., Fayn, E. T., Roach, K. C., and Steele, B. W., Failure of Centers for Disease Control criteria to identify hepatitis B infection in a large municipal obstetrical population,Ann. Intern. Med. 107: 335 – 337 (1987).

    Google Scholar 

  93. Joshi, Y. K., Babu, S., Sarin, S., Tandon, B. N., Gandhi, B. M., and Chaturvedi, V. C., Immunoprophylaxis of epidemic Non-A Non-B hepatitis,Indian J. Med. Res. 81: 18 – 19 (1985).

    Google Scholar 

  94. Judson, F. N., Epidemiology of sexually transmitted hepatitis B infections in heterosexuals: A review,Sex. Transm. Dis. 8(Suppl.): 336 – 343 (1981).

    Google Scholar 

  95. Kane, M. A., Bradley, D. W., Shrestha, S. M., Maynard, J. E., Cook, E. H., Mishra, R. P., and Joshi, D. D., Epidemic Non-A, Non-B hepatitis in Nepal. Recovery of a possible etiologic agent and transmission studies in marmosets,JAMA 252: 3140 – 3145 (1984).

    Article  Google Scholar 

  96. Kennedy, R. C., Eichberg, J. W., Lanford, R. E., and Dreesman, G. R., Anti-idiotypic antibody vaccine for type B viral hepatitis in chimpanzees,Science 232: 220 – 223 (1986).

    Article  Google Scholar 

  97. Khuroo, M. S., Study of an epidemic of Non-A, Non-B hepatitis. Possibility of another human hepatitis virus distinct from posttransfusion Non-A, Non-B type,Am. J. Med. 68: 818 – 824 (1980).

    Article  Google Scholar 

  98. Khuroo, M. S., Duermeyer, W., Zargar, S. A., Ahanger, M. A., and Shah, M. A., Acute sporadic Non-A, Non-B hepatitis in India,Am. J. Epidemiol. 118: 360 – 364 (1983).

    Google Scholar 

  99. Khuroo, M. S., Saleem, M., and Teli, M. R., Failure to detect chronic liver disease after epidemic Non-A, Non-B hepatitis,Lancet 2: 98 (1978).

    Google Scholar 

  100. Khuroo, M. S., Teli, M. R., Skidmore, S., Sofi, M. A., and Khuroo, M. I., Incidence and severity of viral hepatitis in pregnancy,Am. J. Med. 70: 252 – 255 (1981).

    Article  Google Scholar 

  101. Knodell, R. G., Conrad, M. E., Ginsberg, A. L., and Bell, C. J., Efficacy of prophylactic gamma-globulin in preventing Non-A, Non-B post-transfusion hepatitis,Lancet 1: 557 – 561 (1976).

    Article  Google Scholar 

  102. Knodell, R. G., Conrad, M. E., and Ishak, K. G., Development of chronic liver disease after acute Non-A, Non-B post–transfusion hepatitis,Gastroenterology 72: 902 – 909 (1977).

    Google Scholar 

  103. Kobayashi, H., Tsuzuki, M., Koshimizu, K., Toyama, H., Yoshihara, N., Shikata, T., Abe, K., Mizuno, K., Otomo, N., and Oda, T., Susceptibility of hepatitis B virus to disinfectants or heat,J. Clin. Microbiol. 20: 214 – 216 (1984).

    Google Scholar 

  104. Koff, R. S., Pannuti, C. S., Pereira, M. L. G., Hansson, G., Dienstag, J. L., Neto, V. A., Wong, D. C., and Purcell, R. H., Hepatitis A and Non-A, Non-B viral hepatitis in Sao Paulo, Brasil: Epidemiological, clinical, and laboratory comparisons in hospitalized patients,Hepatology 2: 445 – 448 (1982).

    Article  Google Scholar 

  105. Kohler, P. F., Cronin, R. E., Hammond, W. S., Olin, D., and Carr, R. I., Chronic membranous glomerulonephritis caused by hepatitis B antigen-antibody complexes,Ann. Intern. Med. 81: 448 – 451 (1974).

    Google Scholar 

  106. Koretz, R. L., Stone, O., and Gitnick, G. L., The longterm course of Non-A, Non-B post-transfusion hepatitis,Gastroenterology 79: 893 – 898 (1980).

    Google Scholar 

  107. Kremastinou, J., Kalapothaki, V., and Trichopoulos, D., The changing epidemiologic pattern of hepatitis A infection in urban Greece,Am. J. Epidemiol. 120: 703 – 706 (1984).

    Google Scholar 

  108. Krugman, S., Giles, J. P., and Hammond, J., Infectious hepatitis: Evidence for two distinctive clinical, epidemiological, and immunological types of infection,J.A.M.A. 200: 95 – 103 (1967).

    Article  Google Scholar 

  109. Krugman, S., Giles, J. P., and Hammond, J., Hepatitis virus effect of heat on the infectivity and antigenicity of the MS-1 and MS-2 strain,J. Infect. Dis. 122: 423 – 436 (1970).

    Article  Google Scholar 

  110. Krugman, S., Ward, R., Giles, J. P., and Jacobs, A. M., Infectious hepatitis: Studies on the effect of gamma globulin and on the incidence of inapparent infection,J.A.M.A. 174: 823 – 830 (1960).

    Google Scholar 

  111. Kryger, P., Aldersvile, J., Christofferson, P., Hardt, F., Juhl, E., Mathiesen, L. R., Nielsen, J. O., Poulsen, H., and the Copenhagen Acute Hepatitis Program, Acute Non-A, Non-B hepatitis—clinical, epidemiological and histological characteristics,Scand. J. Infect. Dis. 12: 165 – 169 (1980).

    Google Scholar 

  112. Kumar, M. L., Dawson, N. B., McCullough, A. J., Radivoyevith, N., King, K. C., Hertz, R., Kiefer, H., Hampson, M., Cassidy, R., and Tavill, A. S., Should all pregnant women be screened for hepatitis B?Ann. Intern. Med. 107: 273 – 277 (1987).

    Google Scholar 

  113. Lednar, W. M., Lemon, S. M., Kirkpatrick, J. W., Redfield, R. R., Fields, M. L., and Kelley, P. W., Frequency of illness associated with hepatitis A virus infection in adults,Am. J. Epidemiol. 122: 226 – 233 (1985).

    Google Scholar 

  114. Lemon, S. M., Type A viral hepatitis: New developments in an old disease,N. Engl. J. Med. 313: 1059 – 1067 (1985).

    Article  Google Scholar 

  115. Lemon, S. M., and Binn, L. N., Serum neutralizing antibody response to hepatitis A virus,J. Infect. Dis. 148: 1033 – 1039 (1983).

    Article  Google Scholar 

  116. Lettau, L., McCarthy, J. G., Smith, M. H., Hadler, S., Morse, L. J., Ukena, T., Bessette, R., Gurwitz, A., Irvine, W. G., Fields, H. A., Grady, G. F., and Maynard, J. E., An outbreak of severe hepatitis due to delta and hepatitis B viruses in parenteral drug abusers and their contacts,N. Engl. J. Med. 317: 1256 – 1261 (1987).

    Article  Google Scholar 

  117. Marinier, E., Barrois, B., Larouze, B., London, W. T., Cofer, A., Diakhate, L., and Blumberg, B. S., A lack of perinatal transmission of hepatitis B virus infection in Senegal, West Africa,J. Pediatr. 106: 843 – 849 (1985).

    Article  Google Scholar 

  118. Mathieson, L. R., Skinholj, P., Nielson, J. O.. Purcell, R. H., Wong, D. C., and Ranek, L., Hepatitis type A, B, and Non-A, Non-B in fulminant hepatitis,Gut 21: 72 – 77 (1980).

    Article  Google Scholar 

  119. Maupas, P., Chiron, J.-P., Barin, F., Coursaget, P., Goudeau, A., Parrin, J., Denis, F., and Diop-Mar, I., Efficacy of hepatitis B vaccine in prevention of early HBsAg carrier state in children. Controlled trial in an endemic area (Senegal),Lancet 1: 289 – 292 (1981).

    Article  Google Scholar 

  120. Maynard, J. E., Hepatitis B vaccine: Strategies for utilization, in:Hepatitis B vaccine(P. Maupas and P. Guesry, eds.), pp. 13–19, INSERM Symposium No. 18, Elsevier/North-Holland Biomedical Press, Amsterdam, 1981.

    Google Scholar 

  121. Maynard, J. E., Epidemic Non-A, Non-B hepatitis,Semin. Liver Dis. 4: 336 – 339 (1984).

    Article  Google Scholar 

  122. Maynard, J. E., Hadler, S. C., and Fields, H. A., Delta hepatitis in the Americas: An overview,Prog. Clin. Biol. Res. 234: 493 – 505 (1986).

    Google Scholar 

  123. McMahon, B. L., Alward, W. L. M., Hall, D. B., Heyward, W. L., Bender, T. R., Krantz, T. P., and Maynard, J. E., Acute hepatitis B infection: Relation of age to the clinical expression of disease and subsequent development of the carrier state,J. Infect. Dis. 151: 599 – 603 (1985).

    Article  Google Scholar 

  124. McMahon, D. J., Bender, T. R., Berquist, K. R., Schreeder, M. T., and Harpster, A. P., Delayed development of antibody to hepatitis B surface antigen for symptomatic infection with hepatitis B virus,J. Clin. Microbiol. 14: 130 – 134 (1981).

    Google Scholar 

  125. Melnick, J. L., A waterborne urban epidemic of hepatitis, in:Hepatitis Frontiers(F. W. Hartman, G. A. LoGrippo, J. G. Matffer, and J. Barron, eds.), pp. 211 – 225, Little, Brown, Boston, 1957.

    Google Scholar 

  126. Mosley, J. W., Redeker, A. G., Feinstone, S. M., and Purcell, R. H., Multiple hepatitis viruses in multiple attacks of acute viral hepatitis,N. Engl. J. Med. 296: 75 – 78 (1977).

    Article  Google Scholar 

  127. Mushahwar, I. K., McGrath, L. C., Drnec, J., and Overby, L. R., Radioimmunoassay for the detection of hepatitis B e antigen and its antibody. Results of clinical evaluation,Am. J. Clin. Pathol. 76: 692 – 697 (1981).

    Google Scholar 

  128. Mutton, K. J., and Gust, I. D., Public health aspects of hepatitis A, in:Hepatitis A(R. J. Gerety, ed.), pp. 133 – 161, Academic Press, Orlando, FL, 1984.

    Google Scholar 

  129. Myint, H., Myint, M. S., Khin, T., Thein, M. M., and Tin, K. N., A clinical and epidemiological study of an epidemic of Non-A, Non-B hepatitis in Rangoon,Am. J. Trop. Med. Hyg. 34: 1183 – 1189 (1985).

    Google Scholar 

  130. Neurath, R., Kent, S. B. H., Parker, K., Prince, A. M., Strick, N., Brotman, B., and Sproul, P., Antibodies to a synthetic peptide from the pre-S 120–145 region of the hepatitis B virus envelope are virus-neutralizing,Vaccine 4: 35 – 36 (1986).

    Article  Google Scholar 

  131. Noble, R. C., Kane, M. A., Reeves, S. A., and Roeckel, I., Posttransfusion hepatitis A in a neonatal intensive care unit,J.AM.A. 252: 2711 – 2715 (1984).

    Google Scholar 

  132. Norkrans, G., Clinical, epidemiological and prognostic aspects of hepatitis A, B and Non-A, Non-B,Scand. J. Infect. Dis. 17(Suppl.): 1 – 44 (1978).

    Google Scholar 

  133. Osterholm, M. T., and Garayalde, S. M., Clinical viral hepatitis B among Minnesota hospital personnel. Results of a 10 year statewide survey,J.A.M.A. 254: 3207 – 3212 (1985).

    Article  Google Scholar 

  134. Petersen, N. J., Barrett, D. H., Bond, W. H., Berquist, K. R., Favero, M. S., Bender, T. R., and Maynard, J. E., Hepatitis B surface antigen in saliva, impetiginous lesions, and the environment in two remote Alaskan villages,Appl. Environ. Microbiol. 32: 572 – 574 (1976).

    Google Scholar 

  135. Ponzetto, A., Forzani, B., Parravicini, P. P., Hele, C., Zanetti, A., and Rizzetto, M., Epidemiology of delta virus infection,Eur. J. Epidemiol. 1: 257 – 263 (1986).

    Google Scholar 

  136. Prince, A. M., An antigen detected in the blood during the incubation period of serum hepatitis,Proc. Natl. Acad. Sci. U.S.A. 60: 814 – 821 (1968).

    Article  Google Scholar 

  137. Provost, P. J., Bishop, R. P., Gerety, R. J., Hilleman, M. R., McAleer, W. J., Scolnick, E. M., and Stevens, C. E., New findings in live attenuated hepatitis A vaccine development,J. Med. Virol. 20: 165 – 175 (1986).

    Article  Google Scholar 

  138. Provost, P. J., and Hilleman, M. R., Propagation of human hepatitis A virus in cell culturein vitro, Proc. Soc. Exp. Biol. Med 80: 213 – 221 (1979).

    Google Scholar 

  139. Purcell, R. H., Feinstone, S. M., Ticehurst, J. R., Daemer, R.J., and Baroudy, B. M., Hepatitis A virus, in:Viral Hepatitis and Liver Disease(G. N. Vyas, J. L. Dienstag, and J. H. Hoofnagle, eds.), pp. 9 – 22, Grune & Stratton, Orlando, FL, 1984.

    Google Scholar 

  140. Purcell, R. H., and Gerin, J. L., Hepatitis B subunit vaccine: A preliminary report of safety and efficacy tests in chimpanzees,Am. J. Med. Sci. 270: 395 – 399 (1975).

    Article  Google Scholar 

  141. Purcell, R. H., Satterheld, W. C., Bergmann, K. F., Smedile, A., Ponzetto, A., and Gerin, J. L., Experimental hepatitis delta virus infection in the chimpanzee,Prog. Clin. Biol. Res. 234: 27 – 36 (1986).

    Google Scholar 

  142. Rizzetto, M., Canese, M. C., Arico, S., Crivelli, O., Trepo, C., Bonino, R., and Verme, G., Immunofluorescence detection of a new antigen-antibody system (8/anti-8) associated to the hepatitis B virus in the liver and in the serum of HBsAg carriers,Gut 18: 997 – 1003 (1977).

    Article  Google Scholar 

  143. Rizzetto, M., Canese, M. G., Gerin, J. L., London, W. T., Sly, I. D., and Purcell, R. H., Transmission of the hepatitis B virus associated delta antigen to chimpanzees,J. Infect. Dis. 141: 590 – 601 (1980).

    Article  Google Scholar 

  144. Rizzetto, M., Verme, G., Recchia, S., Bonino, F., Farci, P., Arico, S., Calzia, R., Picciotto, A., Colombo, M., and Popper, H., Chronic hepatitis in carriers of hepatitis b surface antigen with intrahepatic expression of the delta antigen. An active and progressive disease unresponsive to immunosuppressive treatment,Ann. Intern. Med. 8: 437 – 441 (1981).

    Google Scholar 

  145. Romet-Lemonne, J. L., McLane, M. F., Elfassi, E., Haseltine, W. A., Azocar, J., and Essex, M., Hepatitis B virus infection in cultured human lymphoblastoid cells,Science 221: 667 – 669 (1983).

    Article  Google Scholar 

  146. Rosina, F., Saracco, G., Bona, P., Lattore, V., Smedile, A., Acns, G. C., Maran, E., Sansalvatore, F., Grezzana, P., Giorda, N. A., Rizzetto, M., and Verme, G., Treatment of chronic delta hepatitis with alpha-2 recombinant interferon, J. Med. Virol 21(4):123A (1987).

    Article  Google Scholar 

  147. Sampliner, R. E., Woronow, D. I., Alter, M. J., Smallwood, L. A., Tabor, E., Deinhardt, F., Roggendorf, M., and Gerety, R. J., Community acquired Non-A, Non-B hepatitis: Clinical characteristics and chronicity,J. Med. Virol. 13: 125 – 130 (1984).

    Article  Google Scholar 

  148. Schimpf, K., Mannucci, P. M., Kreutz, W., Brackmann, H. H., Auerswald, G., Ciavarella, N., Mosseler, J., DeRosa, V., Kraus, B., Brueckmann, C., Mancuso, G., Mittler, U., Haschke, F., and Morfini, M., Absence of hepatitis after treatment with a pasteurized factor VIII concentrate in patients with hemophilia and no previous transfusions,N. Engl. J. Med. 316: 918 – 922 (1987).

    Article  Google Scholar 

  149. Schreeder, M. T., Bender, T. R., McMahon, B. J., Moser, M. R., Murphy, B. L., Sheller, N. J., Heyward, W. L., Hall, D. B., and Maynard, J. E., Prevalence of hepatitis B in selected Eskimo villages,Am. J. Epidemiol. 118: 543 – 549 (1983).

    Google Scholar 

  150. Schreeder, M. T., Thompson, S. C., Hadler, S. C., Berquist, K. R., Zaidi, A., Maynard, J. E., Ostrow, D., Judson, F. N., Braff, E. H., Nylund, T., Moore, J. N., Jr., Gardner, P., Doto, I. L., and Reynolds, G. L., Hepatitis B in homosexual men: Prevalence of infection and factors related to transmission,J. Infect. Dis. 146: 7 – 15 (1982).

    Article  Google Scholar 

  151. Seeff, L., Zimmerman, H. J., Wright, E. C., Finkelstein, J. D., Garcia-Pont, P., Greenlee, H. B., Dietz, A. A., Leevy, C. M., Tamburro, C. H., Schiff, E. R., Schimmel, E. M., Zemel, R., Zimmon, D. S., and McCollum, R. W., A randomized, double-blind controlled trial of the efficacy of immune serum globulin for the prevention of posttransfusion hepatitis: A Veterans Administrative cooperative study,Gastroenterology 72: 111 – 121 (1977).

    Google Scholar 

  152. Shaw, F. E., Sudman, J. H., Smith, S. M., Williams, D. L., Kapell, L. A., Hadler, S. C., Halpin, T. J., and Maynard, J. E., A community-wide epidemic of hepatitis in Ohio,Am. J. Epidemiol. 123: 1057 – 1065 (1986).

    Google Scholar 

  153. Shaw, F. E., Jr., Barrett, C. L., Hamm, R., Peare, R. B., Coleman, P. J., Hadler, S. C., Fields, H. A., and Maynard, J. E., Lethal outbreak of hepatitis B in a dental practice,J.A.M.A. 255: 3260 – 3264 (1986).

    Article  Google Scholar 

  154. Siebke, J. C., Degre, M., Ritland, S., and Enger, S. C., Prevalence of hepatitis A antibodies in a normal population and some selected groups in Norway,Am. J. Epidemiol. 115: 185 – 191 (1982).

    Google Scholar 

  155. Smedile, A., Dentico, P., Zanetti, A., Sagnelli, E., Nordenfelt, E., Actis, G. C., and Rizzetto, M., Infection with the HBV-associated delta (8) agent in HBsAg carriers,Gastroenterology 81: 992 – 997 (1981).

    Google Scholar 

  156. Smedile, A., Farci, P., Verme, G., Caredda, F., Cargnel, A., Caporaso, N., Dentico, P., Trepo, C., Opolon, P., Gimson, A., Vergani, D., Williams, R., and Rizzetto, M., Influence of delta infection on the severity of hepatitis B,Lancet 2: 9 – 15 (1982).

    Google Scholar 

  157. Smedile, A., Lavarini, C., Farci, P., Arico, S., Marinucci, G., Dentico, P., Arico, S., Giuliani, G., Cargnel, A., Blando, C. V., and Rizzetto, M., Epidemiologic patterns of infection with the hepatitis B virus associated delta agent in Italy,Am. J. Epidemiol. 117: 223 – 229 (1983).

    Google Scholar 

  158. Smedile, A., Rizzetto, M., Denniston, K., Bonino, F., Wells, F., Verme, G., Consolo, F., Hoyer, B., Purcell, R. H., and Gerin, J. L., Type D hepatitis: The clinical significance of hepatitis D virus RNA in serum as detected by a hybridization–based assay,Hepatology 6: 1297 – 1302 (1986).

    Article  Google Scholar 

  159. Sobeslavsky, O., Prevalence and markers of hepatitis B infection in various countries. A WHO collaborative study,Bull. WHO 58: 621 – 628 (1980).

    Google Scholar 

  160. Stapleton, J. T., Jansen, R., and Lemon, S. M., Serum neutralizing antibody to hepatitis A virus in immune serum globulin and in the sera of human recipients of immune serum globulin,Gastroenterology 89: 637 – 642 (1985).

    Google Scholar 

  161. Stevens, C. E., Aach, R. D., Hollinger, F. B., Mosley, J. W., Szmuness, W., Kahn, R., Werch, J., and Edwards, V., Hepatitis B virus antibody in blood donors and the occurrence of Non-A, Non-B hepatitis in transfusion recipients: An analysis of the Transfusion Transmitted Virus Study,Ann. Intern. Med. 101: 733 – 738 (1984).

    Google Scholar 

  162. Stevens, C. E., Neurath, R. A., Beasley, R. P., and Szmuness, W., HBeAg and anti-HBe detection by radioimmunoassay: Correlation of vertical transmission of hepatitis B virus in Taiwan,J. Med. Virol. 3: 237 – 241 (1979).

    Article  Google Scholar 

  163. Stevens, C. E., Taylor, P. E., Tong, M. J., Toy, P. T., Vyas, G. N., Nair, E. V., Weissman, J. Y., and Krugman, S., Yeast-recombinant hepatitis B vaccine. Efficacy with hepatitis immune globulin in prevention of perinatal hepatitis B virus transmission,JA.M.A. 257: 2612 – 2616 (1987).

    Article  Google Scholar 

  164. Summers, J., Replication of hepatitis B virus, in:Viral Hepatitis and Liver Disease(G. N. Vyas, J. L. Dienstag, and J. H. Hoofnagle, eds.), pp. 87 – 96, Grune & Stratton, Orlando, 1984.

    Google Scholar 

  165. Summers, J., and Mason, W. S., Properties of the hepatitis B-like virus as related to their taxonomic classification,Hepatology 2(Suppl.): 61 – 66 (1982).

    Google Scholar 

  166. Szmuness, W., Dienstag, J. L., Purcell, R. H., Stevens, C. E., Wong, D. C., Ikram, H., Bar-Shany, S., Beasley, R. P., Desmyter, J., and Gaon, J. A., The prevalence of antibody to hepatitis A antigen in various parts of the world: A pilot study, Am.J. Epidemiol 106: 392 – 398 (1977).

    Google Scholar 

  167. Szmuness, W., Stevens, C. E., Harley, E. J., Zang, E. A., Olesko, W. R., William, E. C., Sadovsky, R., Morrison, J. M., and Kellner, A., Hepatitis B vaccine: Demonstration of efficacy in a controlled clinical trial in a high-risk population in the United States,N. Engl. J. Med. 303: 833 – 841 (1980).

    Article  Google Scholar 

  168. Tandon, B. N., Joshi, Y. K., Jain, S. K., Gandhi, B. M., Mathiesen, L. R., and Tandon, H. D., Epidemic of Non-A, Non-B hepatitis in North India,Indian J. Med. Res 75:739– 744 (1982).

    Google Scholar 

  169. Tassopoulos, N. C., Papavangelou, G. J., Ticehurst, J. R., and Purcell, R. H., Fecal excretion of Greek strains of hepatitis A virus in patients with hepatitis A and in experimentally infected chimpanzees,J. Infect. Dis. 154: 231 – 237 (1986).

    Article  Google Scholar 

  170. Thomas, H. C., Pignatelli, M., Goodall, A., Waters, J., Karayiannis, P., and Brown, D., Immunologic mechanisms of cell lysis in hepatitis B virus infection, in:Viral Hepatitis and Liver Disease(G. N. Vyas, J. L. Dienstag, and J. H. Hoofnagle, eds.), pp. 167 – 177, Grune & Stratton, Orlando, FL, 1984.

    Google Scholar 

  171. Tiollais, P., Charnay, P., and Vyas, G. N., Biology of hepatitis B virus,Science 213: 406 – 411 (1981).

    Article  Google Scholar 

  172. Tong, M. J., Thursby, M., Rakela, J., McPeak, C., Edwards, V. M., and Mosley, J. W., Studies on maternal-infant transmission of the viruses which cause acute hepatitis,Gastroenterology 80: 999 – 1004 (1981).

    Google Scholar 

  173. Toti, M., Rizzi, R., Almi, P., Palla, M., and Bonino, F., Complexes between HBsAg and IgM in serum of patients with acute hepatitis.J. Med. Virol. 11: 139 – 145 (1983).

    Article  Google Scholar 

  174. Verme, G., Amoroso, P., Lettieri, G., Pierri, P., David, E., Sess, F., Rizzi, R., Bonino, F., Recchia, S., and Rizzetto, M., A histological study of hepatitis delta virus liver disease,Hepatology 6: 1303 – 1307 (1986).

    Article  Google Scholar 

  175. Villarejos, V. M., Serra, C. J., Anderson-Visona, K., and Mosley, J. W., Hepatitis A virus infection in households,Am. J. Epidemiol. 115: 577 – 586 (1982).

    Google Scholar 

  176. Villarejos, V. M., Visona, K. A., Eduarte, C. A., Provost, P. J., and Hilleman, M. R., Evidence for viral hepatitis other than type A or type B among persons in Costa Rica,N. Engl. J. Med. 293: 1350 – 1352 (1975).

    Article  Google Scholar 

  177. Vis wan ath an, R., Certain epidemiological features of infectious hepatitis during the Delhi Epidemics, 1955–1956, in:Hepatitis Frontiers(F. W. Hartman, G. A. LoGrippo, J. G. Matffer, and J. Barron, eds.), pp. 207 – 210, Little, Brown, Boston, 1957.

    Google Scholar 

  178. Wang, K. -S., Structure, sequence and expression of the hepatitis delta viral genome,Nature 323: 508 – 513 (1986).

    Article  Google Scholar 

  179. Weller, I. V. D., Fowler, M. J. F., Monjardino, J., and Thomas, H. C., The detection of HBV-DNA in serum by a molecular hybridisation: A more sensitive method for the detection of complete HBV particles,J. Med. Virol. 9: 273 – 280 (1982).

    Article  Google Scholar 

  180. Wong, D. C., Purcell, R. H., Sreenivasan, M. A., Prasad, S. R., and Pavri, K. M., Epidemic and endemic hepatitis in India: Evidence for a Non-A, Non-B hepatitis virus aetiology,Lancet 2: 876 – 878 (1980).

    Article  Google Scholar 

  181. Wong, V. C. W., Ip, H. M. H., Reesink, H. W., Lelie, P. N., Reerink-Brongers, E. E., Yeung, C. Y., and Ma, H. K., Prevention of the HBsAg carrier state in newborn infants of mothers who are chronic carriers of HBsAg and HBeAg by administration of hepatitis-B vaccine and hepatitis-B immunoglobulin. Double blind randomised placebo–controlled study,Lancet 1: 921 – 926 (1984).

    Article  Google Scholar 

  182. Xu, D.-Z., Zhou, W.-Y., Zou, H.-K., and Chen, Y.-J., Etiological types and epidemiological features of acute viral hepatitis in Xi’an in China,J.Med. Virol. 21:283–287(1987).

    Article  Google Scholar 

  183. Xu, Z.-Y., Liu, C.-B., Francis, D. P., Purcell, R. H., Gun, Z.-I., Duan, S.-C., Chen, R.-J., Margolis, H. S., Huang, C.-H., Maynard, J. E., and the United States-China Cooperative Study Group on Hepatitis B, Prevention of perinatal acquisition of hepatitis B virus carriage using vaccine: Preliminary report of a randomized, double-blind placebo-controlled and comparative trial,Pediatrics 76: 713 – 718 (1985).

    Google Scholar 

  184. Zanetti, A., Ferroni, P., Magliano, E. M., Pirovano, P., Lavarini, C., Massoro, A. L., Gavinelli, R., Fabris, C., and Rizzetto, M., Perinatal transmission of hepatitis B virus and the HBV-associated delta agent from mothers to offspring in northern Italy,J. Med. Virol. 9: 139 – 144 (1982).

    Article  Google Scholar 

  185. Zuckerman, A. J., The history of viral hepatitis from antiquity to present, in:Viral Hepatitis: Laboratory and Clinical Science(F. Deinhardt and J. Dienhardt, eds.), pp. 3 – 32, Marcel Dekker, New York, 1983.

    Google Scholar 

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  1. Hepatitis Branch, Division of Viral Diseases, Centers for Disease Control, Atlanta, Georgia, 30333, USA

    Stephen C. Hadler & Harold S. Margolis

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    Alfred S. Evans

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Hadler, S.C., Margolis, H.S. (1989). Viral Hepatitis. In: Evans, A.S. (eds) Viral Infections of Humans. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0705-1_13

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