Use of 1H MRS of Plasma and Tissue in Cancer Detection and Management
In November 1986 Fosse! and coworkers published an article (1) which caused a flurry of activity in both NMR and oncology laboratories around the world. This article suggested that 1H NMR of plasma could be used to detect the presence of cancer. Although never stated as such, the inference was that this test could be used to screen an asymptomatic population for cancer. Since we were already applying 1H NMR in cancer detection and management we decided to test the waters with respect to application of the Fossel test.
KeywordsTriglyceride Concentration Adrenocortical Carcinoma Borderline Ovarian Tumour Methyl Group Ratio Ottawa Civic Hospital
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- 6.Smith ICP, Smart CR, Feller W et al: Magnetic resonance spectroscopy of plasma from populations of normal, high risk, and cancer patients: Correlation with plasma triglycerides. New Engl. J. Med. (in press).Google Scholar
- 7.Barclay M, Skipski VP: Lipoproteins in relation to cancer. Prog. Biochem. Pharmacol. 10:78, 1975.Google Scholar
- 14.Remin M, Somorjai RL, Deslauriers R et al: 1H magnetic resonance of human tumours. Analysis of the transverse relaxation of the methylene protons using continuous distributions of relaxation times. NMR in Biomedicine, in press.Google Scholar