Abstract
Prediction of radiocurability, chemotherapeutic sensitivity or other therapeutic efficacy of cancer by means of laboratory tests has long been searched for. For example, Glucksmann and coworkers tried to correlate histopathological changes to clinical outcome in individual patients (with uterine cervical carcinoma) as early as 1941 (1). Atkin et al. (2) showed (on human cervical cancer cells) that cancers with near-diploid DNA content tended to be more radioresistant than tetraploid tumors. Kolstad (3) correlated the tissue oxygen concentration with the initial response to radiotherapy. Potential lethal damage repair (PLDR) and labeling index depression has been used by Weishselbaum (4) and Tubiana and Malaise (5) respectively to estimate radiocurability. In prediction of tumor response to chemotherapeutic agents, the stem cell assay (6,7) has been employed. Others have studied in vitro radiobiological parameters as potential predictors (8,9). However, all these predictive assays are invasive, time consuming procedures and lack accuracy due to heterogeneity of tumors and limited by biopsying only a very small part of the tumor mass.
Keywords
- Magnetic Resonance Spectroscopy Study
- Uterine Cervical Carcinoma
- Cytidine Diphosphate
- Time Magnetic Resonance Spectroscopy
- Metabolite Alteration
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Glucksmann A: Preliminary observation on the quantitative examination of human biopsy material taken from irradiated carcinomas. Br. J. Radiol. 14:187–197, 1941.
Atkin WB, Mattinson G, Baker MC: A comparison of the DNA content and chromosome numbers of fifty human tumors. Br. J. Cancer 20:87, 1966.
Kolstad P: Oxygen tension and local recurrence in cervix cancer. Scand. J. Clin. Lab. Invest. 22:145–157, 1968.
Wei scheibaum RR, Dahlberg W, Little JB: Inherently radioresistant cells exist in some human tumors. Proc. Natl. Acad. Sci. 82:4732–4735, 1985.
Tubiana M, Malaise E: Comparison of cell proliferation kinetics in human and experimental tumors: Response to irradiation. Cancer Treat. Rep. 60:1887–1895, 1976.
Salmon S: Cloning of human tumor stem cells. In: Progress in Clinical and Biological Research, S Salmon (ed), New York, A.R. Liss, 48:3–13, 1980.
Selby P, Buick RN, Tannock I: A critical appraisal of the “human tumor stem-cell assay”. N. Engl. J. Med. 308:129–134, 1983.
Fertil B, Malaise EP: Intrinsic radiosensitivity of human cell lines is correlated with radioresponsiveness of human tumors: Analysis of 101 published survival curves. Int. J. Radiat. Oncol. Biol. Phys. 11:1699–1707, 1985.
Vijayakumar S, Ng TC, Raudkivi U, Meaney TF: Mean inactivation dose (D): A neglected parameter-A critical analysis. Acta Oncologica 28:475–781. 1989.
Ng TC, Lilly MB, Brezovich I et al: 31P NMR studies related to various modalities of cancer therapy. In: Abstracts of the 22nd Experimental NMR Conference 1981. Asilomar, CA, Experimental NMR Conference A-19, 1981.
Ng TC, Evanochko WT, Hiramoto RN et al: 31P NMR spectroscopy of in vivo tumors. J. Magn. Res. 49:271–286, 1982.
Lilly MB, Katholi CR, Ng TC: Loss of high-energy phosphate following hyperthermia demonstrated by in vivo 31P nuclear magnetic resonance spectroscopy. Cancer Res. 44:633–638, 1984.
Schiffer LM, Braunschweiger PC, Glickson JD et al: Preliminary observations on the correlation of proliferative phenomena with in vivo 31P NMR spectroscopy after tumor chemotherapy. Ann. NY Acad. Sci. 461:270–277, 1986.
Lilly MB, Katholi CR, Ng TC: Direct relationship between high energy phosphate content and blood flow in thermally treated tumors. JNCI 75:885–889, 1986.
Evanochko WT, Sakai TT, Ng TC et al: NMR study of in vivo RIF-1 tumor. Analysis of perchloric acid extracts and identification of 1H, 31P, 13C resonances. Biochem. Biophys. Acta. 805:104–116, 1984.
Sijens PE, Bovee WMMJ, Sejikens D et al: In vivo 31P nuclear magnetic resonance study of the response of a murine mammary tumor to different doses of gamma-radiation. Cancer Res. 46:1427–1432, 1986.
Okunieff P, McFarland E, Rummeny E et al: Effects of oxygen on the metabolism of murine tumors using in vivo 31P NMR. Am. J. Clin. Oncol. 10:475–482, 1987.
Koutcher JA, Okunieff P, Neuringer L et al: Size dependent changes in tumor phosphate metabolism after radiation therapy as detected by 31P NMR spectroscopy. Int. J. Radiat. Oncol. Biol. Phys. 13:1851–1855, 1987.
Evelhoch JL, Keller NA, Corbett TH: Response-specific adriamycin sensitivity markers provided by in vivo 31P nuclear magnetic resonance spectroscopy in murine mammary adenocarcinomas. Cancer Res. 47:3396–3401, 1987.
Bottomley PA, Hart HR, Edelstein WJ et al: NMR imaging/ spectroscopy system to study both anatomy and metabolism. Lancet 2:273–274, 1983.
Ng TC, Majors AW, Meaney TF: In vivo MRS studies of human subjects with a 1.4T MRI system. Radiology 158:517–520, 1986.
Ng TC, Majors AW, Meaney TF et al: In vivo 13P MRS study of human tumors in response to radiation therapy using 1.5T MRI system. In: Magnetic Resonance in Cancer, PS Allen, DP Biosvert, BC Lentie (eds), Toronto, pp. 133–134, 1986.
Oberhaersli RD, Hilton-Jones D, Bore PJ et al: Biochemical investigation of human tumors in vivo with phosphorus-31 magnetic resonance spectroscopy. Lancet 2:8–11, 1986.
Ng TC, Vijayakumar S, Majors AW et al: Response of a non-Hodgkin lymphoma to 60Co therapy monitored by 31P MRS in situ. Int. J. Radiat. Oncol. Biol. Phys. 13:1545–1551, 1987.
Ng TC, Vijayakumar S, Majors AW, Meaney TF: Application of in situ MRS to clinical oncology. Cancer Bull. 40:126–134, 1988.
Ng TC, Majors AW, Vijayakumar S et al: pH of human neoplasms and its alteration in response to radiotherapy measured by 31P MRS in situ. Radiology 170:875–878, 1989.
Ng TC, Grundfest S, Vijayakumar S et al: Therapeutic response of breast carcinoma monitored by 31P MRS in situ. Magn. Reson. Med. 10:125–134, 1989.
Maris JM, Evans AE, McLaughlin AC et al: 31P nuclear magnetic resonance spectroscopic investigation of human neuroblastoma in situ. N. Engl. J. Med. 312:1500–1505, 1985.
Griffiths JR, Cada E, Edward RHT et al: 31P NMR studies of a human tumor in situ. Lancet 1:1436–1437, 1983.
Frahm J, Bruhn H, Gyngell ML et al: Localized proton NMR spectroscopy in different regions of the human brain in vivo. Magn. Reson. Med. 11:47–63, 1989.
Bruhn H, Frahm J, Gyngell, ML et al: Non-invasive differentiation of tumors with use of localized 1H MR spectroscopy in vivo. Initial experience in patients with cerebral tumors. Radiology 172:541–548, 1989.
Roberts JKM, Jardetzky O: Monitoring of cellular metabolism by NMR. Biochem. Biophys. Acta. 639:53–76, 1981.
Meyer RA, Fisher MJ, Nelson SJ, Brown TR: Observer bias in manual integration of phosphorus NMR spectra. In: Book of Abstracts of 7th Annual Meeting of SMRM (eds SMRM), California, Vol. 2, pg. 945, 1988.
Evelhoch JL, Crowley MG, Ackerman JJH: Signal-to-noise optimization and observed volume localization with circular surface coils. J. Magn. Reson. 56:110–112, 1984.
Majors AW, Ng TC, Xue M, Meaney TF: Monitoring of therapeutic response of human superficial tumors using phase encoded spectroscopy. Magn. Reson. Med. 12:369–378, 1989.
Ross B, Helpser JT, Cox IJ, Young IR: Osteosarcoma and other neoplasms of bone. Arch. Surg. 122:1464–1469, 1987.
Arnold DL, Shoubridge EA, Feindel W, Villemure JG: Metabolic changes in cerebral gliomas within hours of treatment with intra-arterial BCNU demonstrated by phosphorus magnetic resonance spectroscopy. Can. J. Neurol. Sci. 14:570–575, 1987.
Heindel W, Bunke J, Glathe S et al: Combined 1H-MR imaging and localized P31-spectroscopy of intracranial tumors in 43 patients. J. Comput. Assist. Tomogr. 12:907–916, 1988.
Wike-Hooley JL, Haveman J, Reinhold HS: The relevance of tumour pH to the treatment of malignant disease. Radiother. Oncol. 2:343–366, 1984.
Van Den Berg AP, Wike-Hooley JL, Broekmeyer-Reurink MP et al: The relationship between the unmodified initial tissue pH of human tumours and the response of combined radiotherapy and local hyperthermic treatment. Eur. J. Cancer Clini. Oncol. 25:73–78, 1989.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Kluwer Academic Publishers, Boston
About this chapter
Cite this chapter
Ng, T.C., Vijayakumar, S., Majors, A., Tefft, M. (1990). In Situ 31P-MRS as a Potential Predictor for Therapeutic Response of Human Neoplasms. In: Evelhoch, J.L., Negendank, W., Valeriote, F.A., Baker, L.H. (eds) Magnetic Resonance in Experimental and Clinical Oncology. Developments in Oncology, vol 61. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0691-7_10
Download citation
DOI: https://doi.org/10.1007/978-1-4613-0691-7_10
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8028-6
Online ISBN: 978-1-4613-0691-7
eBook Packages: Springer Book Archive