Renal Disorders in Liver Disease

  • Murray Epstein


Cirrhosis of the liver is a common clinical condition that afflicts a major portion of the population of the United States. The importance of this disease is underscored by reports indicating that the age-adjusted death rate (14.8 deaths/100,000 population) for cirrhosis has increased by 67% between 1950 and 1969, ranking it as the tenth leading cause of death in the United States (1). At least 600,000 Americans (3.6 of every 1000 adults in the U.S. population) are estimated to have cirrhosis, but many think this figure greatly underestimates the prevalence of this disorder. Since most patients with cirrhosis have ascites and edema during the course of the disease, the impact of ascites on health care is enormous. Included among the numerous complications that affect the course of cirrhosis are derangements of renal function. Since several studies have indicated that renal failure occurs in 50–75% of patients dying of cirrhosis (2, 3), extrapolation of these data underscore the clinical importance of this complication.


Cirrhotic Patient Pulmonary Capillary Wedge Pressure Ascitic Fluid Sodium Retention Hepatorenal Syndrome 
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  • Murray Epstein

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