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Vesicoureteral Reflux and Reflux Nephropathy

  • Priscilla Kincaid-Smith

Abstract

For many years the treatment of vesicoureteral reflux has been regarded as an area that concerned the urologist and not the nephrologist. It has been assumed that treatment of this condition, if indicated, was surgical. However, the place of surgery in the treatment of vesicoureteral reflux remains controversial. The importance of medical management in the control of infection and of other complications has gained considerable support over recent years.

Keywords

Scar Formation Vesicoureteral Reflux Renal Scarring Malignant Hypertension Glomerular Lesion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Hodson CJ, Edwards D: Chronic pyelonephritis and vesi-coureteric reflux. Clin Radiol 11:219–231, 1960.PubMedCrossRefGoogle Scholar
  2. 2.
    Hodson CJ: The mechanism of scar formation in chronic pyelonephritis. In: Kincaid-Smith P, Fairley KF (eds) Renal Infection and Renal Scarring. Mercedes, Melbourne, 1971, p 327.Google Scholar
  3. 3.
    Hodson CJ, Maling TM, McManamon PJ, Lewis MG: The pathogenesis of reflux nephropathy (chronic atrophic pyelonephritis). Br J Radiol (Suppl 13): 1–26, 1975.PubMedGoogle Scholar
  4. 4.
    Rolleston GL, Maling TM, Hodson CJ: Intrarenal reflux and the scarred kidney. Arch Dis Child 49: 531–539, 1974.PubMedCrossRefGoogle Scholar
  5. 5.
    Heale WF: Age of presentation and pathogenesis of reflux nephropathy. In: CJ Hodson, P Kincaid-Smith, eds, Reflux Nephropathy. Masson Publishing, New York, p 140, 1979.Google Scholar
  6. 6.
    Kincaid-Smith P: Discussion: Classification of glomerulonephritis. In: P Kincaid-Smith, TH Mathew, EL Becker, eds, Glomerulonephritis: Morphology, Natural History and Treatment. John Wiley & Sons, New York, p 155, 1973.Google Scholar
  7. 7.
    Kincaid-Smith P: The prevention of renal failure. In: Proceedings of the 6th International Congress of Nephrology, Vol 3. Mexico, 1972. Karger, Basel, pp 100–118, 1974.Google Scholar
  8. 8.
    Kincaid-Smith P: Glomerular lesions in atrophic pyelonephritis and reflux nephropathy. Kidney Int 8 (Suppl 4): 81–83, 1975.Google Scholar
  9. 9.
    Kincaid-Smith P: The Kidney: a Clinicopathological Study. Blackwell Scientific Publications, London, p 354, 1975.Google Scholar
  10. 10.
    Kincaid-Smith P: Glomerular and vascular lesions in chronic atrophic pyelonephritis and reflux nephropathy. In: J Hamburger, J Crosnier, MH Maxwell, eds, Advances in Nephrology. Year Book Medical, Chicago, pp 3–17, 1975.Google Scholar
  11. 11.
    Kincaid-Smith P, Becker GJ: Reflux nephropathy in the adult. In: CJ Hodson, P Kincaid-Smith, eds, Reflux Nephropathy. Masson Publishing, New York, pp 21–28, 1979.Google Scholar
  12. 12.
    Kincaid-Smith P, Becker GJ: Reflux nephropathy and chronic atrophic pyelonephritis: A review. J Infect Dis 138:774–780, 1978.PubMedCrossRefGoogle Scholar
  13. 13.
    Fairley KF, Birch DF: Haematuria: Glomerular or non-glomerular. Lancet 2:845, 1979.PubMedGoogle Scholar
  14. 14.
    Fairley KF, Birch DF: Haematuria: A simple method for identifying glomerular bleeding. Kidney Int 21:105–108, 1981.CrossRefGoogle Scholar
  15. 15.
    Heale WF, Ferguson RS: The pathogenesis of renal scarring in children. In: EH Kass, W Brumfitt, eds, Infections of the University of Chicago Press, Chicageo, p 201, 1978.Google Scholar
  16. 16.
    Smellie J, Edwards D, Hunter N, Normond ICS, Prescod N: Vesicoureteric reflux and reflux scarring. Kidney Int 8 (Suppl 4):65–72, 1975.Google Scholar
  17. 17.
    Kunin CM: Emergence of bacteriuria, proteinuria and symptomatic urinary tract infections among a population of school girls followed for 7 years. Paediatrics 41:968, 1968.Google Scholar
  18. 18.
    Cardiff-Oxford Bacteriuria Study Group: Sequelae of covert bateriuria in schoolgirls. A four year follow-up study. Lancet 1:889–893, 1978.Google Scholar
  19. 19.
    Rolleston GL: The significance and management of vesicoureteric reflux in infancy. Part 2. Radiological aspects. In: P Kincaid-Smith, KF Fairley, eds, Renal Infection and Renal Scarring. Mercedes, Melbourne, p 246, 1971.Google Scholar
  20. 20.
    Fairley KF, Butler HM: Sterile pyuria as a manifestation of occult bacterial pyelonephritis with special reference to intermittent bacteriuria. In: P Kincaid-Smith, KF Fairley, eds, Renal Infection and Renal Scarring. Mercedes, Melbourne, p 51, 1971.Google Scholar
  21. 21.
    Birch DF, Fairley KF, Pavillard RE: Unconventional bacteria in urinary tract disease: Ureaplasma urealyticum. Kindney Int 19:58–64, 1981.CrossRefGoogle Scholar
  22. 22.
    Fairley KF, Becker GJ, Butler HM, McDowall DRM, Leslie DW: Diagnosis in the difficult case. Kidney Int 8:S12–S19, 1975.Google Scholar
  23. 23.
    Longcope WT: Chronic bilateral pyelonephritis: Its origin and its association with hypertension. Ann Intern Med 11:149, 1937.Google Scholar
  24. 24.
    Weiss S, Parker F Jr: Pyelonephritis: Its relation to vascular lesions and to arterial hypertension. Medicine 18:221, 1939.CrossRefGoogle Scholar
  25. 25.
    Kincaid-Smith P: Vascular obstruction in chronic pyelo-nephritic kidneys and its relation to hypertension. Lancet 2:1263–1269, 1955.CrossRefGoogle Scholar
  26. 26.
    Brod J: Chronic pyelonephritis. Lancet 1:1973, 1956.Google Scholar
  27. 27.
    Bengtsson U, Hogdahi A-M, Hood B: Chronic nonobstructive pyelonephritis and hypertension: A long-term study. J Med 37:361, 1968.Google Scholar
  28. 28.
    Heptinstall RH: Malignant hypertension: A study of 51 cases. J Pathol Bacteriol 65:423, 1953.PubMedCrossRefGoogle Scholar
  29. 29.
    Kincaid-Smith P, McMichael J, Murphy EA: The clinical course and pathology of hypertension with papilloedema (malignant hypertension). J Med (New Series 27): 117–153, 1958.Google Scholar
  30. 30.
    Kimmelstiel P, Kim OJ, Beres JA, Wellmann K: Chronic pyelonephritis. Am I Med 30:589, 1961.CrossRefGoogle Scholar
  31. 31.
    Holland HN, Kotchen T, Bhathena D: Hypertension in children with chronic pyelonephritis. Kidney Int 8 (Suppl 5):243–251, 1975.Google Scholar
  32. 32.
    Holland NH: Reflux nephropathy and hypertension. In: W Hodson, P Kincaid-Smith, eds, Reflux Nephropathy. Masson publishing, New York, p 257, 1979.Google Scholar
  33. 33.
    Andersen HJ, Jacobsson B, Larsson H, Winberg J: Hypertension, asymmetric renal parenchymal defect, sterile urine and high E. coli antibody titre. Br Med J 3:14–18, 1973.PubMedCrossRefGoogle Scholar
  34. 34.
    Still JL, Cottom D: Severe hypertension in childhood. Arch Dis Child 42:34–39, 1967.PubMedCrossRefGoogle Scholar
  35. 35.
    Savage JM, Dillon MJ, Shah V, Barratt TM, Williams D: Renin and blood pressure in children with renal scarring and vesicoureteric reflux. Lancet 2:441–444, 1978.PubMedCrossRefGoogle Scholar
  36. 36.
    Poutasse F, Stecker J Jr, Ladage LE, Sperber E: Malignant hypertension in children secondary to chronic pyelonephritis: Laboratory and radiological indications for partial or total nephrectomy. J Urol 119:264–267, 1978.PubMedGoogle Scholar
  37. 37.
    Dillon MJ, Smellie JM: Peripheral plasma renin activity, hypertension and renal scarring in children. In: CJ Hodson, RH Heptinstall, J Winberg, eds, Reflux Nephropathy Update 1983. Karger, Basel. Contr Nephrol 39:68–80, 1984.Google Scholar
  38. 38.
    Kincaid-Smith P: Clinical implications of reflux in the adult. In: W Zurukzoglu, M Papadimitriou, M Pyrpasopoulos, M Sion, C Zamboulis, eds, Proceedings of the 8th International Congress of Nephrology, Athens, 1981. Karger, Basel, pp 359–362, 1981.Google Scholar
  39. 39.
    Heptinstall RH, Hodson CJ: Pathology of sterile reflux in the pig. In: CJ Hodson, RH Heptinstall, J Winberg, eds, Reflux Nephropathy Update 1983. Karger, Basel. Contr Nephrol 39:344–357, 1984.Google Scholar
  40. 40.
    Bailey RR, McRae CU, Maling TM, Tisch G, Little PJ: Renal vein renin concentration in the hypertension of unilateral reflux nephropathy. J Urol 120:21–23, 1978.PubMedGoogle Scholar
  41. 41.
    Hodson CJ: Sterile reflux. In: W Zurukzoglu, M Papadimitriou, M Pyrpasopoulos, M Sion, C Zamboulis, eds, Proceedings of the 8th International Congress of Nephrology, Athens, 1981. Karger, Basel, pp 368–373, 1981.Google Scholar
  42. 42.
    Ransley PG: The renal papilla, intrarenal reflux and chronic pyelonephritis. In: W Zurukzoglu, M Papadimitriou, M Pyrpasopoulos, M Sion, C Zamboulis, eds, Proceedings of the 8th International Congress of Nephrology, Athens, 1981. Darger, Basel, pp 363–367, 1981.Google Scholar
  43. 43.
    Kincaid-Smith P, Hodson CJ: Lesions in the pig kidney with chronic reflux nephropathy. In: CJ Hodson, P Kincaid-Smith, eds, Reflux Nephropathy. Masson Publishing, New York, pp 197–212, 1979.Google Scholar
  44. 44.
    Ransley AG, Risdon RA: Reflux and renal scarring. Br I Radiol (Suppl 14): 1978.Google Scholar
  45. 45.
    Cotran RS, Hodson CJ: Extratubular localization of Tamm-Horsfall protein in experimental reflux nephropathy in the pig. In: Hodson CJ, Kincaid-Smith P (eds) Reflux Nephropathy. Masson Publishing, New York, p 213, 1979.Google Scholar
  46. 46.
    Hoyer JR: Tubulointerstitial immune complex nephritis in rats immunized with Tamm-Horsfall protein. Kidney Int 17:284–292, 1980.PubMedCrossRefGoogle Scholar
  47. 47.
    Fasth A, Hanson LA, Fodal U, Peterson H: Antibodies to Tamm-Horsfall protein associated with urinary tract infections in girls. J Pediatr 95:54–60, 1979.PubMedCrossRefGoogle Scholar
  48. 48.
    Hoyer JR, Ishidate T: Pathophysiology of Tamm-Horsfall protein in tubulointerstitial nephritis. In: W Zurukzoglu, M Papdimitriou, M Pyrpasopoulos, M Sion, C Zamboulis, eds, Proceedings of the 8th International Congress of Nephrology, Athens, 1981. Karger, Basel, pp 783–789, 1981.Google Scholar
  49. 49.
    Fasth A, Jodal U: Autoantibodies against Tamm-Horsfall Protein: Their usefulness as indicators of presence of renal damage and reflux. In: W Zurukzoglu, M Papadimitriou, M Pyrpasopoulos, M Sion, C Zamboulis, eds, Proceedings of the 8th International Congress of Nephrology, Athens, 1981. Karger, Basel, pp 790–796, 1981.Google Scholar
  50. 50.
    Stephens FD, Lenaghan D: The anatomical basis and dynamics of vesicoureteral reflux. J Urol 87:669, 1962.PubMedGoogle Scholar
  51. 51.
    Morillo MM, Orandi A, Fernandes M, Draper JW: Vesicoureteral reflux in male adults with bladder neck obstruction. J Urol 89:389, 1963.Google Scholar
  52. 52.
    Zatz LM: Combined physiologic and radiologic studies of bladder function in female children with recurrent urinary tract infection. Invest Urol 3:278, 1965.PubMedGoogle Scholar
  53. 53.
    Lenaghan D, Cussen LJ: Vesicoureteral reflux in pups. Invest Urol 5:449, 1968.PubMedGoogle Scholar
  54. 54.
    Koff SA, Lapides J, Piazza DH: The uninhibited bladder in children: A cause for urinary obstruction, infection and reflux. In: CJ Hodson, P Kincaid-Smith, eds, Reflux Nephropathy. Masson Publishing, New York, pp 161–170, 1979.Google Scholar
  55. 55.
    Allen TD: Vesicoureteral reflux as a manifestation of dysfunctional voiding. In: CJ Hodson, P Kincaid-Smith, eds, Reflux Nephropathy. Masson Publishing, New York, p 171, 1979.Google Scholar
  56. 56.
    Van Gool JD: Bladder infection and pressure. In: CJ Hodson, P Kincaid-Smith, eds, Reflux Nephropathy. Masson Publishing, New York, p 181, 1979.Google Scholar
  57. 57.
    Godec CJ, Eshq J, Cass AS: Correlation among cystometry, urethral pressure profilometry and pelvic floor electromyog-raphjy in the evaluation of female patients with voiding dysfunction symptoms. J Urol 124:678–682, 1980.PubMedGoogle Scholar
  58. 58.
    Shopfner CE: Roentgenological evaluation of bladder neck obstruction. Am J Roentegenol 100:162–176, 1967.Google Scholar
  59. 59.
    Stamey TA: Urinary infections in infancy and childhood. In: Pathogenesis and Treatment of Urinary Tract Infections. Williams & Wikins, Baltimore, p 310, 1980.Google Scholar
  60. 60.
    Van Gool JD, Kuitjen RH, Donckerwolcke RA, Messer AP, Vijverberg M: Bladder-sphincter dysfunction, urinary infection and vesico-ureteral reflux with special reference to cognitive bladder training. In: CJ Hodson, RH Heptinstall, J Winberg, eds, Reflux Nephropathy Update 1983. Karger, Basel. Contr Nephrol 39:190–210, 1984.Google Scholar
  61. 61.
    Aladjem M, Schoeneman MJ, Bennett B, Levitt S, Spitzer A, Greifer T: Focal segmental glomerulosclerosis with proteinuria and chronic interstitial nephritis. N Y State J Med:519, 1978.Google Scholar
  62. 62.
    Bhatena DB, Weiss JH, Holland NH, McMorrow RG, Curtis JJ, Lucas Ba, Luke EG: Focal and segmental glomerular sclerosis in reflux nephropathy (chronic pyelonephritis). Am J Med 68:886–892, 1980.CrossRefGoogle Scholar
  63. 63.
    Senekjian HO, Stinebaugh BJ, Mattioli CA, Suki WN: Irreversible renal failure following vesicoureteral reflux. JAMA 241:169, 1979.CrossRefGoogle Scholar
  64. 64.
    Torres VE, Velosa JA, Holley KE, Kelalis PP, Stickler GB, Kurtz SB: The progression of vesicoureteral reflux nephropathy. Ann Intern Med 92:776, 1980.PubMedGoogle Scholar
  65. 65.
    Cotran RS: Pathogenetic mechanisms in the progression of reflux nephropathy: The roles of glomerulosclerosis and extravasation of Tamm-Horsfall protein. In: W Zurukzoglu, M Papadimitriou, M Pyrpasopoulos, M Sion, C Zamboulis, eds, Proceedings of the 8th International Congress of Nephrology, Athens, 1981. Karger, Basel, pp 374–381, 1981.Google Scholar
  66. 66.
    Shimamura T, Morrison AB: A progressive glomerulosclerosis occurring in partial five-sixth nephrectomized rats. Am J Pathol 79:95–106, 1975.PubMedGoogle Scholar
  67. 67.
    Kincaid-Smith P: Glomerular lesions in atrophic pyelonephritis (RN). In: P Kincaid-Smith, J Hodson, eds, Reflux Nephropathy. Masson Publishing, New York, pp 268–272, 1979.Google Scholar
  68. 68.
    Kincaid-Smith P: Diffuse parenchymal lesions in reflux nephropathy and the possibility of making a renal biopsy diagnosis in reflux nephropathy. In: GM Berlyne, S Giovanetti, eds, Contributions to Nephrology. Karger, Basel, 1984, 39:111–115.Google Scholar
  69. 69.
    Kiprov DD, Colvin RB, McCluskey RT: Focal and segmental glomerulosclerosis and proteinuria associated with unilateral renal agenesis. Lab Invest 46:275–281, 1982.PubMedGoogle Scholar
  70. 70.
    Bhathena DB, Julian BA, McMorrow RG, Baehler RW: Focal sclerosis of hypertrophied glomeruli in solitary func-tining kidneys of humans. Am J Kid Dis 5:226–232, 1985.PubMedGoogle Scholar
  71. 71.
    Hostetter TH, Olson JL, Rennke HG, Venkatachatan MA, Brenner BM: Hyperfiltration in remnant nephrons: A potentially adverse response to renal ablation. Am J Physiol 241:585–592, 1981.Google Scholar
  72. 72.
    Kincaid-Smith P: Pyelonephritis, chronic interstitial nephritis and obstructive uropathy. In: J Hamburger, ed, Nephrology. John Wiley & Son, New York, pp 553–582, 1979.Google Scholar
  73. 73.
    Bakshardeh K, Charles L, Carrion H: Vesicoureteral reflux and end stage renal disease. J Urol 116:557–558, 1976.Google Scholar
  74. 74.
    Hodson CJ, Twohaill SA: The time factor in the development of sterile renal scarring following high-pressure vesicoureteral reflux. In: CJ Hodson, RH Heptinstall, J Winberg, eds, Reflux Nephropathy Update 1983. Karger, Basel. Contr Nephrol 39:358–369, 1984.Google Scholar
  75. 75.
    Hodson CJ, Craven JD: Experimental obstructive nephropathy in the pig. Br J Urol 14 (Suppl 6):3–57, 1969.Google Scholar
  76. 76.
    Winberg J, Claesson I, Jacobsson B, Jodal U, Petersen H: Renal growth after acute pyelonephritis in childhood: An epidemiological approach. In: CJ Hodson, P Kincaid-Smith, eds, Reflux Nephropathy. Masson Publishing, New York, p 309, 1979.Google Scholar
  77. 77.
    Normand C, Smellie J: Vesicoureteric reflux: The case for conservative management. In: CJ Hodson, P Kincaid-Smith, eds, Reflux Nephropathy. Masson Publishing, New York, p 281, 1979.Google Scholar
  78. 78.
    Asscher AW, Chick S: Increased susceptibility of the kidney to ascending Escherichia coli infection following unilateral nephrectomy. Br J Urol 44:202, 1972.PubMedCrossRefGoogle Scholar
  79. 79.
    Smellie JM, Ransley PG, Normand ICS, Prescod N, Edwards D: Development of new renal scars: A collaborative study. Br Med J 290:1957–1960, 1985.CrossRefGoogle Scholar
  80. 80.
    Rolleston GL, Shannon FT, Utley WLF: Relationship of infantile vesicoureteric reflux to renal damage. Br Med J 1:460, 1970.PubMedCrossRefGoogle Scholar
  81. 81.
    Smellie JM, Gruneberg RN, Leakey EN, Atkin W: Long-term low dose co-trimoxazole in prophylaxis of childhood urinary tract infection — clinical aspects. Br Med J 2:203–206, 1976.PubMedCrossRefGoogle Scholar
  82. 82.
    Birmingham Reflux Study Group: Prospective trial of operative versus non-operative treatment of severe vesicoureteric relfux: Two years’ observation in 96 children. Br Med J 287:171–174, 1983.CrossRefGoogle Scholar
  83. 83.
    Filly RA, Friedland GW, Goven DE, Fair WR: Development and progression of clubbing and scarring in children with recurrent urinary tract infections. Radiology 113:145–153, 1974.PubMedGoogle Scholar
  84. 84.
    Lenaghan D, Whitaker JG, Jensen F, Stephens FD: The natural history of reflux and long-term effects of reflux on the kidney. J Urol 115:728–730, 1976.PubMedGoogle Scholar
  85. 85.
    Edwards D, Normand ICS, Prescod N, Smellie JM: Disappearance of vesicoureteric reflux during long-term prophylaxis of urinary tract infection in children. Br Med J 2:285–288, 1977.PubMedCrossRefGoogle Scholar
  86. 86.
    Friedland GW: Post-reimplantation renal scarring. In: CJ Hodson, P Kincaid-Smith, eds, Reflux Nephropathy. Mas-son Publishing, New York, p 323, 1979.Google Scholar
  87. 87.
    Kincaid-Smith P, Friedman A, Nanra RS: Controlled trials of treatment in urinary tract infection. In: P Kincaid-Smith, KF Fairley, eds, Renal Infection and Renal Scarring. Mercedes Publishing Services, Melbourne, pp 165–174, 1971.Google Scholar
  88. 88.
    Kincaid-Smith P, Fairely KF: Controlled trial comparing effect of two and six weeks treatment in recurrent urinary tract infection. Br Med J 2:145–146, 1969.PubMedCrossRefGoogle Scholar
  89. 89.
    Fairley KF, Whitworth JA, Kincaid-Smith P, Durman O: Single dose therapy in the management of urinary tract infection. Med J Aust 2:75–76, 1978.PubMedGoogle Scholar
  90. 90.
    Stamey TA: General and specific principles of therapy. In: Pathogenisis and Treatment of Urinary Tract Infections. Williams & Wilkins, Baltimore, p 569, 1980.Google Scholar
  91. 91.
    Stamey TA: Urinary tract infections in women. In: Pathogenesis and Treatment of Urinary Tract Infections. Williams & Wilkins, Baltimore, p 143, 1980.Google Scholar
  92. 92.
    Lincoln K, Lidin-Janson G, Winberg J: Treatment trials in urinary tract infection with special reference to the effect of antibodies on the faecal flora. In: P Kincaid-Smith, KF Fairley, eds, Renal Infection and Renal Scarring. Mercedes, Melbourne, p 151, 1971.Google Scholar
  93. 93.
    Richmond JM, Whitworth JA, Fairley KF, Kincaid-Smith P: Co-trimoxazole nephrotoxicity. Lancet 1:493, 1979.PubMedCrossRefGoogle Scholar
  94. 94.
    Kalowski S, Nanra RS, Mathew TH, Kincaid-Smith P: Deterioration in renal function in association with Co-trimoxazole therapy. Lancet 1:394–397, 1973.PubMedCrossRefGoogle Scholar
  95. 95.
    Harding GKM, Buckwald FJ, Marrie TJ, Thompson L, Light RB, Ronald AR: Prophylaxis of recurrent urinary tract infection in female patients. JAMA 242 (18).T975–1977, 1979.CrossRefGoogle Scholar
  96. 96.
    Kalowski S, Radford N, Kincaid-Smith P: Crystalline and macrocrystalline nitrofurantoin in the treatment of urinary tract infection. N Engl J Med 290:385–387, 1974.PubMedCrossRefGoogle Scholar
  97. 97.
    Fairley KF: Hypertension and renal disease in pregnancy. In: W Zurukzoglu, M Papadimitriou, M Pyrpasopoulos, M Sion, C Zamboulis, eds, Proceedings of the 8th International Congress of Nephrology, Athens, 1981. Karger, Basel, pp 440–444, 1981.Google Scholar
  98. 98.
    Fairley KF: Hypertension associated with oral contraceptive agents and hypertension in pregnancy. In: P Kincaid-Smith, JA Whitworth, eds, Hypertension: Mechanisms and Management. ADIS Science Press, Sydney, pp 112–116, 1982.Google Scholar
  99. 99.
    Fang P, MacDonald IM, Laver M, Hua A, Kincaid-Smith P: Oral diazoxide in uncontrolled malignant hypertension. Med J Aust 2:621–624, 1974.8PubMedGoogle Scholar
  100. 100.
    Kincaid-Smith P, Fang P, Laver MC: A new look at the treatment of severe hypertension. Clin Sci Mol Med 45:75S–87S, 1973.Google Scholar
  101. 101.
    Kincaid-Smith P: The treatment of resistant hypertension. Drugs 11 (Suppl 1):78–86, 1976.PubMedCrossRefGoogle Scholar
  102. 102.
    Hollenbers NK, Douglass FA, McKinstry DW, Williams GH, Borucki LJ, Sulivan JM: Beta-adrenoreceptor blocking agents and the kidney: Effect of nadolol and proparanolol on the renal circulation. Br J Clin Pharmacol 7 (Suppl 2):219S–225S, 1979.Google Scholar
  103. 103.
    Hollenberg NK, Swartz SL, Dian R, Passan BS, Williams GH: Increased glomerular filtration rate after converting enzyme inhibition in essential hypertension. N Engl J Med 301:9–12, 1979.PubMedCrossRefGoogle Scholar
  104. 104.
    Hricick DE, Brownong PJ, Kopelman R, Goorno WE, Madias NE, Dzau VJ: Captopril-induced functional renal insufficiency in patients with bilateral renal-artery stenoses or renal-artery stenosis in a solitary kidney. N Engl J Med 308:373–376, 1983.CrossRefGoogle Scholar
  105. 105.
    Curtis JJ, Luke RG, Whelchel JD, Diethelm AG, Jones P, Dustan HP: Inhibition of angiotensin-converting enzyme in renal transplant recipients with hypertension. N Engl J Med 308:377–381, 1983.PubMedCrossRefGoogle Scholar
  106. 106.
    Kincaid-Smith P: Role of ACE inhibitors in treatment of hypertension — experience with renovascular hypertension. In: Doyle AE, Beam AG (eds) Hypertension and the Angiotensin System: Therapeutic Approaches. Raven Press, New York, pp 233–240, 1984.Google Scholar
  107. 107.
    Meyer TW, Hostetter TH, Rennke HG, Noddin JL, Brenner BM: Preservation of renal structure and function by long term protein restriction in rats (abstract). Kidney Int 23:218, 1983.Google Scholar
  108. 108.
    Meyer TW, Anderson S, Rennke HG, Brenner BM: Control of glomerular hypertension retards progression of established glomerular injury in rats with renal ablation (abstract). Kidney Int 27:247, 1985.Google Scholar
  109. 109.
    Purkeson ML, Hoffsten PE, Klahr S: Pathogenesis of the glomerulopathy associated with renal infarction in rats. Kidney Int 9:407–417, 1976.CrossRefGoogle Scholar
  110. 110.
    Purkeson ML, Joist JH, Greenberg JM, Kay D, Hoffsten PE, Klahr S: Inhibition by anticoagulant drugs of the progressive hypertension and uremia associated with renal infarction in rats. Thromb Res 26:227–240, 1982.CrossRefGoogle Scholar
  111. 111.
    Purkeson ML, Joist JH, Yates J, Klahr S: Role of hypertension and coagulation in the glomerulopathy of rats with subtotal renal ablation. In: Abstracts IX International Congress on Nephrology, Los Angeles, p 359A, 1984.Google Scholar
  112. 112.
    Gretz N, Korb E, Strauch M: Low-protein diet supplemented by keto acids in chronic renal failure: A prospective controlled study. Kidney Int 24 (Suppl.26):S263-S267, 1983.Google Scholar
  113. 113.
    Rosman JB, Ter Wee PM, Meijer S, Piers-Becht TPM, Slutter WJ, Donker AJM: Prospective randomised trial of early dietary protein restriction in chronic renal failure. Lancet 2:1291–1296, 1984.PubMedCrossRefGoogle Scholar
  114. 114.
    Stephens FD, Lenaghan D: The anatomical basis and dynamics of vesicoureteral reflux. In: R Webster, ed, Congenital Malformations of the Rectum, Anus and Genito-Urinary Tracts. E & S Livingstone, London, p 147, 1963.Google Scholar
  115. 115.
    Stamey TA: Urinary infections in infancy and childhood. In: Pathogenesis and Treatment of Urinary Tract Infections. Williams & Wilkins, Baltimore, p 335, 1980.Google Scholar
  116. 116.
    McRae CU, Shannon FT, Utley WLF: Effect on renal growth of reimplantation of relfuxing ureters. Lancet 1:1310, 1974.PubMedCrossRefGoogle Scholar
  117. 117.
    Bauer SB, Willischer MK, Zammuto PJ, Retik AB: Long-term results of anti-reflux surgery in children. In: CJ Hodson, P Kincaid-Smith, eds, Reflux Nephropathy. Masson Publishing, New York, p 287, 1979.Google Scholar
  118. 118.
    Hendren WH: A ten year experience with ureteral reimplantation in children. In: P Kincaid-Smith, KF Fairley, eds, Renal Infection and Renal Scarring. Mercedes, Melbourne, p 269, 1971.Google Scholar
  119. 119.
    Kincaid-Smith P, Fairley KF: The changing spectrum of acute renal failure in pregnancy and the post-partum period. In: GM Berlyne, ed, Contributions to Nephrology, Vol 25. Karger, Basel, p 159–165, 1981.Google Scholar
  120. 120.
    Kincaid-Smith P, Bullen M: Bacteriuria in pregnancy. Lancet 1:395–399, 1965.PubMedCrossRefGoogle Scholar
  121. 121.
    d’Apice AJF, Reti LL, Pepperell RJ, Fairley KF, Kincaid-Smith P: Treatment of severe pre-eclampsia by plasma exchange. Aust NZ J Obstet Gynaecol 20:231–235, 1980.CrossRefGoogle Scholar
  122. 122.
    Hodson CJ: Reflux nephropathy: Scoring the damage. In: CJ Hodson, P Kincaid-Smith, eds, Reflux Nephropathy. Masson Publishing, New York, pp 29–27, 1979.Google Scholar
  123. 123.
    Aperia A, Broberger O, Ekengren K, Wikstad I: The relationship between renal area and renal function in well defined childhood nephropathies. Acta Radiol Diagn 19:186–196, 1977.Google Scholar

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© Kluwer Academic Publishers 1991

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  • Priscilla Kincaid-Smith

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